Results 101 to 110 of about 4,025 (222)

Heteroatom modified carbohydrate scaffolds in drug discovery

Discover Chemistry
Carbohydrate-derived heteroatom scaffolds have emerged as versatile frameworks in modern drug discovery due to their inherent stereochemical diversity, biocompatibility, and ability to engage biological targets through multiple noncovalent interactions ...
Jyoti Dahiya, Anudeep Kumar Narula, Gulshan Kumar   +2 more
doaj   +1 more source

Electron impact studies. XVIII. Mass spectra of pyridazines, phthalazines, and related compounds

, 1967
The mass spectra of substituted pyridazines, phthalazines, and related compounds are reported and discussed. Molecular ions are a prominent feature of all the spectra, and fragmentation modes may be usefully correlated with both the type of heterocycle ...
HJ Rodda, PF Donaghue, JA Halleday, RG Cooks, JH Bowie   +4 more
core   +1 more source

New potential HEDMs with a pyridazine core: Structural modeling and assessment of thermochemical properties

FirePhysChem
The results of modeling the structure of compounds 2,4,7,9-tetranitrobenzo[c]cinnoline (1) and 1,2,3,4-tetrazino[5,6-f]pyridazino-1,2,3,4-tetrazine 1,3,7,9-tetra-N-oxides (2) containing a pyridazine core are presented.
D.V. Khakimov, T.S. Pivina
doaj   +1 more source

INVERSE-ELECTRON-DEMAND DIELS-ALDER REACTIONS OF CONDENSED PYRIDAZINES, 5. 1 1,4-BIS(TRIFLUOROMETHYL)- PYRIDAZINO[4,5-b]INDOLE AS

, 2008
- The pyridazino[4,5-b]indole (3), which is conveniently available from 3-methylthioindole and the tetrazine (2), undergoes thermally induced inverse-electron-demand Diels-Alder reactions with enamines to afford the cycloalkene-annelated carbazoles (7,8)
Norbert Haider, An Azadiene, Richard Wanko   +2 more
core  

Des imidazo[1,2-b]pyridazines ciblant la CDPK1 comme nouvelle chimiothérapie anti-toxoplasmose

, 2016
Session: Toxoplasma et ToxoplasmoseInternational audienceLe traitement de référence de la toxoplasmose est une association pyriméthamine-sulfamide. Ces molécules ne sont pas spécifiques du parasite et présentent une toxicité importante.
Moine, Espérance, Enguehard-Gueiffier, Cécile, van Langendonck, Nathalie, Moiré, Nathalie, Gueiffier, Alain, Dimier-Poisson, Isabelle, Héraut, Bruno, Debierre-Grockiego, Françoise, Denevault-Sabourin, Caroline   +8 more
core  

Base-induced Oxygenation and Chemiluminescence of 3,6-Disubstituted Pyridazines : A Model for Luminol Chemiluminescence

, 1984
application/pdfMonocyclic 3,6-disubstituted pyridazines were oxidized by molecular oxygen under the basic conditions in dimethyl sulfoxide at room temperature to give the corresponding maleic acids and/or its derivatives with chemiluminescent light ...
Suzuki, Nobutaka, 加藤, 守, Ueyama, Takeshi, 鈴木, 喜隆, 上山, 武士, Kato, Mamoru   +5 more
core  

Doubly cyclopalladated pyridazines: chiral liquid crystals

The mono and dicyclopalladation of new mesogenic pyridazines and subsequent reaction with beta-diketones yields some novel metallomesogens. The monometallated derivatives have a flat central core. In contrast.

core  

Pyrrolo[1,2-b]pyridazines. A revisit

ARKIVOC, 2008
Florea Dumitraşcu, Dan George Dumitrescu   +1 more
doaj   +1 more source

Synthesis of Some Novel Thieno[2,3-c] pyridazines, Triazolo[1’’5’’:1’,6’]pyrimido[4’,5’: 4,5] thieno [2,3-c]pyridazines

, 2009
3,4-Dimethyl-5,6-disubstited-thieno[2,3-c]pyridazines(5a-d, 6, and 7) have been synthesized. 5-Amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carbonitrile (5b) wasused as a key intermediate in the synthesis of novel pyrimido[4’,5’:4,5]thieno[2,3-c ...
Kamal El-Dean, A., Al-Kamali, A.
core  

Net Oxidative Photocatalytic Strategy toward the <i>o</i>-Trifluoroacetylation of <i>N</i>-Heteroarenes. [PDF]

Org Lett
Samony KL, Thullaprambil JZ, Nabi RN, Brunner KE, Kim DK.   +4 more
europepmc   +1 more source