Results 91 to 100 of about 4,025 (222)

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity.

, 2007
Much attention has recently been focused on PIM kinases as potential targets for the treatment of hematopoietic malignancies and some solid cancers. Using protein stability shift assays, we identified a family of imidazo[1,2-b]pyridazines to specifically
Knapp, Stefan, Filippakopoulos, Panagis, Gasser, C, Pogacic, V, Fedorov, O, Bullock, AN, Schwaller, J, Filippakopoulos, P, Biondi, A, Knapp, S, Meyer-Monard, S, Bullock, Alexander   +11 more
core   +1 more source

Effets Électroniques dans les Systèmes Hétérocycliques Aromatiques Spectres de Résonance Magnétique Nucléaire de Pyridazines, Pyrimidines et S‐Triazines Substituées

, 1965
Substituted pyridazines, pyrimidines and s‐triazines yield very simple N.M.R. spectra. Substituent effects of electron releasing groups are enhanced in these heterocycles, and surprisingly large shifts occur at the meta positions.
J. Nasielski, Hinkens, Raymonde, J. De Lannoy, R. Degroote, F. Declerck, R. Nasielski-Hinkens, Degroote, Roland, De Lannoy, J., Declerck, Freddy, Nasielski, Jacques   +9 more
core   +1 more source

Pyridazines. VII. Synthesis of Cyanopyridazines.

Chemical and Pharmaceutical Bulletin, 1963
3-Chloro, 3-methyl, 3-methoxy, 3-benzyloxy, and 3-phenyl-6-cyanopyridazine (III, VI, X, XII, XIV) was synthesized from 3-chloro, 3-methyl, 3-methoxy, 3-benzyloxy, and 3-phenylpyridazine 1-oxide (II, V, IX, XI, XIII).
openaire   +3 more sources

Unravelling the Reaction Mechanism of the Reductive Ring Contraction of 1,2-Pyridazines

, 2016
Substituted pyrroles may be synthesized from selected 1,2-pyridazines through a reductive ring contraction involving the addition of four electrons and four protons.
Pedro J. Silva (2082295)
core   +1 more source

New Potential Pharmaceuticals with Cyclopenta[d]pyridazines and the COX-2 (Cyclooxygenase-2) Connection.

, 2018
The expanding need for new medical treatments for a variety of disorders has driven research to discover new organic compounds as potential pharmaceuticals.
Riffe, David G.
core  

Imidazo[1,2-B]Pyridazines. I. Some 3-Alkoxy-6-Halogeno-2-Phenyl-(and 4′-Substituted Phenyl)Imidazo[1,2-B]Pyridazines and 3-Methoxy-2,6-Diphenylimidazo[1,2-B]Pyridazine

, 1986
A series of 3-alkoxy-6-halogeno-2-phenyl(and 4′-substituted phenyl) imidazo [1,2-b] pyridazines (1) and 3-methoxy-2,6- diphenylimidazo [1,2-b] pyridazine have been prepared from the relevant pyridazin-3-amines and arylglyoxals, followed by O ...
GB Barlin
core   +1 more source

Imidazo[1,2-b]pyridazines and purines : synthesis and biological evaluation of protein kinase inhibitors

, 2012
Le travail s’est articulé autour de la synthèse et de l’évaluation biologique de nouveaux inhibiteurs de protéines kinases dont essentiellement de kinases dépendantes de cyclines (CDKs).
N'gompaza Diarra, Joannah
core  

Inverse-Electron-Demand Diels–Alder Reactions for the Synthesis of Pyridazines on DNA

, 2018
The synthesis of pyridazines on DNA has been developed on the basis of inverse-electron-demand Diels–Alder (IEDDA) reactions of 1,2,4,5-tetrazines. The broad substrate scope is explored.
Xuan Wang (55634), Wenting Wu, Hailong Li (216327), Mingqiang Zhang (1902106), Wenge Zhong (2025574), Hailong Li, Zhen Sun, Xiaojie Lu (1317612), Xiaojie Lu, Wenge Zhong, Xuan Wang, Zhen Sun (269397), Mingqiang Zhang, Dongcheng Dai (2497414), Dongcheng Dai, Wenting Wu (174490)   +15 more
core   +1 more source

Synthesis of Pyridazine Derivatives. IX. Formation of Pyridazines in the ·Reaction of Some Acid Anhydrides with Hydrazines

, 1966
Reaction between 4-cyclohexene-1 ;2-dicarboxylic acid anhydride and hydrazine hydrate was investigated. There were obtained d ifferent products depending on reaction conditions but no pyridazines were formed .
Kuhelj, F., M . Tišler, Stanovnik, B., Tišler, M ., B. Stanovnik, F. Kuhelj   +5 more
core  

New Horizon and Advancements in Synthetic and Biological Applications of Active Methylene Acetonitrile: Mini-Review

Journal of Chemistry
Acetonitrile is generally used as an organic solvent and can also be used as a significant starting material via active methylene acetonitrile in organic synthesis.
Lavanya Nagamalla, Kavitha Kothireddy, Basavarajaiah Suliphuldevara Mathada, Sharanagouda J. Patil, Lavanya Lakshminarayana   +4 more
doaj   +1 more source