Synthesis of Some New Pyridazine Derivatives for Anti-HAV Evaluation [PDF]
Molecules, 2017 4-(2-(4-Halophenyl)hydrazinyl)-6-phenylpyridazin-3(2H)-ones 1a,b were prepared and treated with phosphorus oxychloride, phosphorus pentasulphide and ethyl chloroformate to give the corresponding chloropyridazine, pyridazinethione, oxazolopyridazine ...
Mahmoud El-Shahat +2 more
exaly +4 more sources
Crystal structure of [1,2,4] triazolo[4,3- b ]pyridazine derivatives as BRD4 bromodomain inhibitors and structure–activity relationship study [PDF]
Scientific Reports, 2023 BRD4 contains two tandem bromodomains (BD1 and BD2) that recognize acetylated lysine for epigenetic reading, and these bromodomains are promising therapeutic targets for treating various diseases, including cancers.
Jung-Hoon Kim +7 more
doaj +2 more sources
In silico design of novel pyridazine derivatives as balanced multifunctional agents against Alzheimer’s disease [PDF]
Scientific ReportsAlzheimer’s disease (AD) necessitates innovative therapeutic approaches that target its multifaceted pathology. This study investigates a series of 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as potential multi-target ligands for AD ...
Mourad Aloui +7 more
doaj +2 more sources
Synthesis of Pyridazine Derivatives by Suzuki-Miyaura Cross-Coupling Reaction and Evaluation of Their Optical and Electronic Properties through Experimental and Theoretical Studies [PDF]
Molecules, 2018 A series of π-conjugated molecules, based on pyridazine and thiophene heterocycles 3a⁻e, were synthesized using commercially, or readily available, coupling components, through a palladium catalyzed Suzuki-Miyaura cross-coupling reaction.
Sara S. M. Fernandes +3 more
doaj +2 more sources
International Journal of Electrochemical Science, 2012 The corrosion rates in the presence of new synthesised pyridazine derivatives (P1, P2, P3 and P4) as a steel corrosion inhibitors in 1 M hydrochloric acid, were measured by the weight loss method, in the range of temperatures from 303 to 353 K.
Belkheir Hammouti, M Sfaira, M Taleb
exaly +3 more sources
International Journal of Electrochemical Science, 2012 The effect of adding new pyridazine derivatives, ethyl [4-(2-chlorobenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]acetate (P1), ethyl [4-(2-chlorobenzyl)-3-methyl-6-thioxopyridazin-1(6H)-yl]acetate (P2), 5-(2-chlorobenzyl)-2-(2-hydroxyethyl)-6-methylpyridazin ...
Belkheir Hammouti, M Sfaira, M Taleb
exaly +3 more sources
International Journal of Electrochemical Science, 2013 Corrosion inhibition of two pyridazine derivatives, namely ethyl (6-oxo-3-phenylpyridazin-1(6H)-yl) acetate (GP2) and ethyl (3-phenyl-6-thioxopyridazin-1(6H)-yl) acetate (GP3) on C38 steel was investigated by gravimetric measurements, polarisation and ...
Belkheir Hammouti +2 more
exaly +3 more sources
Molecules, 2021 During the last few decades, pyridazine derivatives have emerged as privileged structures in heterocyclic chemistry, both because of their excellent chemistry and because of their potential applications in medicinal chemistry and optoelectronics.
Dorina Amariucai-Mantu +2 more
doaj +1 more source
USES OF 4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE IN THE SYNTHESIS OF PYRIDAZINE, PYRAZOLE, THIAZOLE AND PYRIMIDINE DERIVATIVES TOGETHER WITH THEIR CYTOTOXICITY [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2014 The reaction of N-phenylbutanamide derivative 1 with bromine afforded compound 2 which it was directed to reacts with activated methylene groups, malononitrile (3a) and ethylcyanoacetae (3b) to produce compounds 4a and 4b respectively, on the other hand ...
Karam El-Sharkawy
doaj +1 more source
Molecular docking studies of N-substituted 4-methoxy-6-oxo-1-aryl-pyridazine-3-carboxamide derivatives as potential modulators of glutamate receptors [PDF]
Research Results in Pharmacology, 2020 Introduction: The virtual target-oriented screening is a necessary stage of modern drug-design. In the present study, the affinity of pyridazine derivatives for the most promising antiparkinsonian biotargets – I–III groups of metabotropic and ionotropic ...
Hanna I. Severina +5 more
doaj +3 more sources