Results 1 to 10 of about 1,846 (173)

Synthesis of Some New Pyridazine Derivatives for Anti-HAV Evaluation [PDF]

Molecules, 2017
4-(2-(4-Halophenyl)hydrazinyl)-6-phenylpyridazin-3(2H)-ones 1a,b were prepared and treated with phosphorus oxychloride, phosphorus pentasulphide and ethyl chloroformate to give the corresponding chloropyridazine, pyridazinethione, oxazolopyridazine ...
Eman M. Flefel, Waled A. Tantawy, Walaa I. El-Sofany, Mahmoud El-Shahat, Ahmed A. El-Sayed, Dina N. Abd-Elshafy   +5 more
doaj   +4 more sources

Crystal structure of [1,2,4] triazolo[4,3- b ]pyridazine derivatives as BRD4 bromodomain inhibitors and structure–activity relationship study [PDF]

Scientific Reports, 2023
BRD4 contains two tandem bromodomains (BD1 and BD2) that recognize acetylated lysine for epigenetic reading, and these bromodomains are promising therapeutic targets for treating various diseases, including cancers.
Jung-Hoon Kim, Navin Pandit, Miyoun Yoo, Tae Hyun Park, Ji U Choi, Chi Hoon Park, Kwan-Young Jung, Byung Il Lee   +7 more
doaj   +2 more sources

In silico design of novel pyridazine derivatives as balanced multifunctional agents against Alzheimer’s disease [PDF]

Scientific Reports
Alzheimer’s disease (AD) necessitates innovative therapeutic approaches that target its multifaceted pathology. This study investigates a series of 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as potential multi-target ligands for AD ...
Mourad Aloui, Mohamed El fadili, Somdutt Mujwar, Mohammed Er-rajy, Hatem A. Abuelizz, Sara Er-rahmani, Sara Zarougui, Elhalaoui Menana   +7 more
doaj   +2 more sources

Synthesis of Pyridazine Derivatives by Suzuki-Miyaura Cross-Coupling Reaction and Evaluation of Their Optical and Electronic Properties through Experimental and Theoretical Studies [PDF]

Molecules, 2018
A series of π-conjugated molecules, based on pyridazine and thiophene heterocycles 3a⁻e, were synthesized using commercially, or readily available, coupling components, through a palladium catalyzed Suzuki-Miyaura cross-coupling reaction.
Sara S. M. Fernandes, João Aires-de-Sousa, Michael Belsley, M. Manuela M. Raposo   +3 more
doaj   +2 more sources

Comparative Inhibition Study of New Synthesised Pyridazine Derivatives Towards Mild Steel Corrosion in Hydrochloric Acid. Part-II: Thermodynamic Proprieties

International Journal of Electrochemical Science, 2012
The corrosion rates in the presence of new synthesised pyridazine derivatives (P1, P2, P3 and P4) as a steel corrosion inhibitors in 1 M hydrochloric acid, were measured by the weight loss method, in the range of temperatures from 303 to 353 K.
B. Zerga, B. Hammouti, M. Ebn Touhami, R. Touir, M. Taleb, M. Sfaira, M. Bennajeh, I. Forssal   +7 more
doaj   +3 more sources

Diazo Transfer From Nitrous Oxide Employing Phosphorus Ylides. [PDF]

Angew Chem Int Ed Engl
A phosphorus ylide‐mediated strategy achieves the direct fixation of nitrous oxide (N2O) to access diazo compounds, which after intra‐ or intermolecular trapping, afford N2‐containing organic building blocks. This approach provides an alternative to hazardous diazo‐transfer reagents and establishes N2O fixation as a sustainable methodology.
Yu JK, Ludwig JN, Antoni PW, Tymann D, Hansmann MM.   +4 more
europepmc   +2 more sources

Effect of New Synthesised Pyridazine Derivatives on the Electrochemical Behaviour of Mild Steel in 1M HCl Solution: Part-1

International Journal of Electrochemical Science, 2012
The effect of adding new pyridazine derivatives, ethyl [4-(2-chlorobenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]acetate (P1), ethyl [4-(2-chlorobenzyl)-3-methyl-6-thioxopyridazin-1(6H)-yl]acetate (P2), 5-(2-chlorobenzyl)-2-(2-hydroxyethyl)-6-methylpyridazin ...
B. Zerga, R. Saddik, B. Hammouti, M. Taleb, M. Sfaira, M. Ebn Touhami, S.S. Al-Deyab, N. Benchat   +7 more
doaj   +3 more sources

Structure-Based Design, Synthesis, and Evaluation of Novel Ponatinib Derivatives With a Significantly Altered Selectivity Profile. [PDF]

ChemMedChem
We developed new derivatives of the cancer drug ponatinib, significantly reducing and altering its spectrum of target kinases. Compound 5 retained the efficacy in inhibiting the colony formation of MDA‐MB‐231 cells and acted primarily on B‐Raf and Flt‐1 as its main targets in a kinase panel.
Betzholz T, Liu T, Krämer A, Dederer V, Knapp S, Mathea S, Ducho C, Engel M.   +7 more
europepmc   +2 more sources

An Investigation of Two Novel Pyridazine Derivatives as Corrosion Inhibitor for C38 Steel in 1.0 M HCl

International Journal of Electrochemical Science, 2013
Corrosion inhibition of two pyridazine derivatives, namely ethyl (6-oxo-3-phenylpyridazin-1(6H)-yl) acetate (GP2) and ethyl (3-phenyl-6-thioxopyridazin-1(6H)-yl) acetate (GP3) on C38 steel was investigated by gravimetric measurements, polarisation and ...
A. Ghazoui, N. Bencaht, S.S. Al-Deyab, A. Zarrouk, B. Hammouti, M. Ramdani, M. Guenbour   +6 more
doaj   +3 more sources

Strategy for the Synthesis of Pyridazine Heterocycles and Their Derivatives [PDF]

The Journal of Organic Chemistry, 2013
The first synthesis of novel fused pyridazines has been realized starting from 1,3-diketones involving a Diaza-Wittig reaction as a key step. A convenient strategy was elaborated to access versatile pyridazine derivatives allowing the variation of substituents at position 6 of the heterocyclic ring.
Belabed, Hassen, Mammoliti, Oscar, Bande, Omprakash, Van Lommen, Guy, Herdewijn, Piet   +4 more
openaire   +3 more sources