Results 31 to 40 of about 2,698 (209)

Coordination‐Driven Direct C─H Metalation of N‐Heterocycles With a Superbasic Co(II) Amide Co(TMP)2

Angewandte Chemie, EarlyView.
By enabling regioselectivities that are inaccessible with conventional bases, this study introduces a Co(II) amide platform for the deprotonative C─H metalation of sensitive N‐heterocycles. Subsequent interception of the resulting Co(II) intermediates with external oxidants affords a family of sterically congested, TMP‐substituted heterocycles via C─N ...
Na Jin, Manting Mu, Max García‐Melchor, Eva Hevia   +3 more
wiley   +2 more sources

Construction of Unusual Indole-Based Heterocycles from Tetrahydro-1H-pyridazino[3,4-b]indoles

Molecules, 2020
Herein, we report the successful syntheses of scarcely represented indole-based heterocycles which have a structural connection with biologically active natural-like molecules.
Cecilia Ciccolini, Lucia De Crescentini, Fabio Mantellini, Giacomo Mari, Stefania Santeusanio, Gianfranco Favi   +5 more
doaj   +1 more source

Theoretical Investigation of Molecular Properties of 5-benzyl-6-methyl pyridazine-3-one and 5-benzyl-6-methyl pyridazine-3-thione and their Potentials for Corrosion Inhibition for Steel

International Journal of Electrochemical Science, 2020
The present study theoretically investigates the molecular properties of two pyridazine derivatives (5-benzyl-6-methyl pyridazine-3-one, PO and 5-benzyl-6-methyl pyridazine-3-thione, PS) using quantum chemical technique (Parameterization Method 3). It is
Ubong Eduok
doaj   +1 more source

Novel Ring Systems: Spiro[Cycloalkane] Derivatives of Triazolo- and Tetrazolo-Pyridazines

Molecules, 2021
In orderto synthesize new pyridazine derivatives anellated with different nitrogen heterocyclic moieties, spiro[cycloalkane]pyridazinones were transformed into the corresponding thioxo derivatives via a reaction with phosphorus pentasulfide. The reaction
Csilla Sepsey Für, Gergő Riszter, Áron SzigetvárI, Miklós Dékány, György Keglevich, László HazaI, Hedvig BölcskeI   +6 more
doaj   +1 more source

Synthesis and Antibacterial Evaluation of Novel Heterocyclic Compounds Containing a Sulfonamido Moiety

Molecules, 2013
Aiming for the synthesis of new heterocyclic compounds containing a sulfonamido moiety suitable for use as antibacterial agents, the precursor ethyl {[4-N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylazo}cyanoacetate was reacted with a variety of active ...
Eman A. El-Bordany, Mohamed M. Youssef, Mohammad Emad Azab   +2 more
doaj   +1 more source

Syntheses of Pyridazine Derivatives as Herbicides

Agricultural and Biological Chemistry, 1965
Various 3-halo-6-phenoxypyridazines, with or without nitro groups on their benzene rings, and 3-anilino-6-phenoxypyridazines were prepared together with some related compounds to be evaluated as herbicides. Ultraviolet spectra of some nitrophenoxypyridazines thus obtained were also examined.
Teruomi JOJIMA, Saburo TAMURA
openaire   +3 more sources

Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer’s disease: a preclinical study in rTg4510 mice

Alzheimer’s Research & Therapy, 2019
Background The lack of effective treatment options for Alzheimer’s disease (AD) is of momentous societal concern. Synaptic loss is the hallmark of AD that correlates best with impaired memory and occurs early in the disease process, before the onset of ...
Joshua B. Foster, Rashelle Lashley, Fangli Zhao, Xueqin Wang, Nydia Kung, Candice C. Askwith, Lin Lin, Michael W. Shultis, Kevin J. Hodgetts, Chien-Liang Glenn Lin   +9 more
doaj   +1 more source

Bis-Pyridazine Derivatives with Anticancer Activity

Proceedings, 2019
Over the last decades, pyridazine derivatives are considered “privileged structures” in medicinal chemistry, with special attention being given to pyridazinones derivatives, which were found to have a large range of biological activities ...
Amariucai-Mantu Dorina, Mangalagiu I. Ionel, Antoci Vasilichia, Mangalagiu Violeta   +3 more
doaj   +1 more source

Study on the Acid⁃Catalyzed Cyclization Reaction of Allylbenzenes and Tetrazine

Shiyou huagong gaodeng xuexiao xuebao
Indeno[1,2⁃d]pyridazine derivatives have wide applications in pesticides,pharmaceuticals,and other fields due to their excellent biological activities.Therefore,the development of rapid and efficient synthetic methods for these compounds has attracted ...
Wenqing LIU, He WANG, Xin WANG, Lei LI
doaj   +1 more source

Synthesis and Antifungal Activity of 5-Chloro-6-Phenylpyridazin-3(2H)-one Derivatives

Molecules, 2009
An effective method has been developed for the preparation under mild conditions of novel pyridazine derivatives from the easily accessible starting materials mucochloric acid and benzene.
Deyu Hu, Pinaki Bhadury, Hongjun Chen, Jian Wu, Baoan Song   +4 more
doaj   +1 more source