Results 41 to 50 of about 1,851 (175)

Nitrogen‐Site Isomerism Unlocks Exciton Dissociation in Vinylene‐Linked COF‐Based Photocatalysts

EcoEnergy, EarlyView.
Two regioisomeric vinylene‐linked covalent organic frameworks (COFs) constructed from diazine units with different nitrogen positions are developed for photocatalytic hydrogen evolution reaction (HER). Although structurally similar, the isomeric COFs exhibit distinct electron distribution and charge‐separation behaviors, leading to a more than twofold ...
Ming Wang, Zhongliang Wen, Chengbo Zhang, Wei Wang, Yaling Li, Xiaofang Su, Rached Ousji, Yanqiong Luo, Muhammad Imran Anwar, Rengui Li, Yanan Gao   +10 more
wiley   +1 more source

Novel heterocyclic hybrids of pyrazole targeting dihydrofolate reductase: design, biological evaluation and in silico studies

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A novel series of pyrazole analogues including hydrazones, pyrazolo[4,3-c]-pyridazines, pyrazolo[3,4-e][1,2,4]triazine and pyrazolo[3,4-d][1,2,3]triazoles was designed, synthesised and screened for their in vitro antimicrobial and DHFR inhibition ...
Ismail M. M. Othman, Mohamed A. M. Gad-Elkareem, Abd El-Galil E. Amr, Mohamed A. Al-Omar, Eman S. Nossier, Elsayed A. Elsayed   +5 more
doaj   +1 more source

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source

The Reaction of Cyclopentanone with Cyanomethylene Reagents: Novel Synthesis of Pyrazole, Thiophene, and Pyridazine Derivatives

Journal of Chemistry, 2013
The reaction of cyclopentanone with either malononitrile or ethyl cyanoacetate gave the corresponding condensated products. The latter underwent some heterocyclic reactions to give new pyrazole, thiophene, and pyridazine derivatives.
Wagnat W. Wardakhan, Eman M. Samir
doaj   +1 more source

Targeting Monoamine Oxidase B for the Treatment of Alzheimer’s and Parkinson’s Diseases Using Novel Inhibitors Identified Using an Integrated Approach of Machine Learning and Computer-Aided Drug Design

Mathematics, 2023
Neurological disorders are disorders characterized by progressive loss of neurons leading to disability. Neurotransmitters such as nor-adrenaline, dopamine, and serotonin are partially regulated by the enzyme monoamine oxidase (MAO).
Arif Jamal Siddiqui, Sadaf Jahan, Maqsood Ahmed Siddiqui, Andleeb Khan, Mohammed Merae Alshahrani, Riadh Badraoui, Mohd Adnan   +6 more
doaj   +1 more source

Pyridazine Derivatives. IV. The Structures of Aminopyridazines.

Chemical and Pharmaceutical Bulletin, 1963
The infrared absorption spectra of the two aminopyridazines were observed and compared with those of the three aminopyridines and aniline. The amino-form of the two aminopyridazines was confirmed, and at the same time the structural similarity of 4-aminopyridazine with 4-aminopyridine was shown by their infrared spectra.
Nitta, Yoshihiro, Tomii, Reiko, Yoneda, Fumio   +2 more
openaire   +3 more sources

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Synthesis of Compounds of the Pyrimidine Series Based on the Reactions of 3-Arylmethylidenefuran-2(3H)-ones with N,N-Binucleophilic Reagents

Molecules, 2017
The arylmethylidene derivatives of furan-2(3H)-ones are important building blocks for the synthesis of various heterocyclic compounds containing pyrimidine and pyridazine structural fragments, analogues of nitrogen-containing bases of pyrimidine series ...
Tatyana Aniskova, Vyacheslav Grinev, Alevtina Yegorova   +2 more
doaj   +1 more source

4,7-Dichloro[1,2,5]oxadiazolo[3,4-d]pyridazine 1-oxide

Molbank, 2018
Dihalogenated derivatives of [1,2,5]chalcogenadiazolo[3,4-d]pyridazines are of interest as precursors for both photovoltaic materials and biologically active compounds.
Timofey Chmovzh, Ekaterina Knyazeva, Vadim Popov, Oleg Rakitin   +3 more
doaj   +1 more source

Formation of Bicyclic Skeletons by Aerobic, Manganese‐Mediated Cyclization of β‐Oxoesters

European Journal of Organic Chemistry, Volume 29, Issue 30, 12 August 2026.
Manganese(III) promotes aerobic radical cyclization reactions of β‐oxoesters with an ω‐alkenyl side chain at the β’‐position to give bicyclic products with a 1,4‐dicarbonyl structure. Bicyclic perhydro‐pentalene, ‐indene, and ‐azulene, as well as decaline skeletons were accessed by aerobic manganese(III)‐mediated radical cyclizations of cyclic β ...
Julian Friedrich, Marc Schmidtmann, Jens Christoffers   +2 more
wiley   +1 more source