Results 51 to 60 of about 2,698 (209)

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Pyridazine-3,4,6-trithiol and some N- and S-methyl derivatives

, 1978
Pyridazine-3,4,6-trithiol has been prepared and its pKa values and U.V. spectra compared with those of some N- and S-methyl derivatives. It is evident that the compound does not exist as the trithiol or as the 1H tautomeric form.
P Lakshminarayana, GB Barlin
core   +1 more source

Microwave Assisted Reactions of Fluorescent Pyrrolodiazine Building Blocks

Molecules, 2019
We report here the synthesis and optical spectral properties of several new pyrrolodiazine derivatives. The luminescent heterocycles were synthesized by 1,3-dipolar cycloaddition reactions between N-alkylated pyridazine and methylpropiolate or dimethyl ...
Costel Moldoveanu, Dorina Amariucai-Mantu, Violeta Mangalagiu, Vasilichia Antoci, Dan Maftei, Ionel I. Mangalagiu, Gheorghita Zbancioc   +6 more
doaj   +1 more source

Synthesis of Heterocyclic Compounds Derived From Dimedone and Their Anti-tumor and Tyrosine Kinase Inhibitions

Acta Chimica Slovenica, 2020
The reaction of dimedone with arylaldehydes gave the benzylidene derivatives 3a–c, the latter underwent a series of heterocyclization reactions to give fused thiophene, pyrazole isoxazole and pyridazine derivatives.
Rafat Mohareb, Fatma Manhi, Amal Abdelwahab   +2 more
doaj   +1 more source

Impact of a pyridazine derivative on tripartite synapse ultrastructure in hippocampus: a three-dimensional analysis

Frontiers in Cellular Neuroscience, 2023
IntroductionWe previously discovered a pyridazine derivative compound series that can improve cognitive functions in mouse models of Alzheimer’s disease.
Zan Xu, Joshua B. Foster, Rashelle Lashley, Xueqin Wang, Emily Benson, Grahame Kidd, Chien-liang Glenn Lin   +6 more
doaj   +1 more source

Cycloaddition Reactions of Benzonorbornadiene and Homonorbornadiene: New Isoxazoline and Pyridazine Derivatives

, 2018
Ten new isoxazoline derivatives were synthesized from the reactions of benzonorbornadiene and homonorbornadiene derivatives with nitrile oxides formed from benzaldehyde and 4-substituted benzaldehyde.
Tutar, Ahmet, Yadigar Adiloglu, Ertan Sahin, Abdullah Menzek, MENZEK, Abdullah, ŞAHİN, Ertan, Ahmet Tutar, Adiloglu, Yadigar   +7 more
core   +1 more source

Synthesis ofN-substituted dibenzoazepine-pyridazine derivatives as potential neurologically active drugs

, 2020
Syntheses of pyridazine derivatives of dibenzoazepine, starting fromN-substituted-dibenzoazepines, are reported here for the first time. In the reaction sequence,N-substitute dibenzoazepine derivatives were synthesized and then, examinedinverseelectron ...
Erdogan, Musa, DAŞTAN, Arif
core   +1 more source

Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives

Chemistry – A European Journal, EarlyView.
Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome, Péter P. Fehér, András Stirling, Csongor G. Németh, Tamás Hergert, György M. Keserű, Péter Ábrányi‐Balogh   +6 more
wiley   +1 more source

Structure–activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators [PDF]

, 2012
Excitatory amino acid transporter 2 (EAAT2) is the major glutamate transporter and functions to remove glutamate from synapses. A thiopyridazine derivative has been found to increase EAAT2 protein levels in astrocytes.
Colton, Craig K., Chang, Ling-Chu, Cuny, Gregory D., Xing, Xuechao, Glicksman, Marcie A., Lin, Chien-Liang G., Kong, Qiongman, Lai, Liching   +7 more
core   +1 more source

Pyrazole[3,4-d]pyridazine derivatives: Molecular docking and explore of acetylcholinesterase and carbonic anhydrase enzymes inhibitors as anticholinergics potentials

, 2019
PubMed: 31470200Recently, the pyridazine nucleus has been widely studied in the field of particular and new medicinal factors as drugs acting on the cardiovascular system.
Bildirici, I., Şen, F., Taslimi, Parham, Karaman, M., Turkan, Fikret, Bildirici, İshak, Sen, Fatih, Cetin, Adnan, Karaman, Muhammet, Burhan, Hakan, Taslimi, P., Türkan, F., Cetin, A., Burhan, H., GÜLÇİN, İlhami   +14 more
core   +2 more sources