Results 71 to 80 of about 1,851 (175)

Synthesis and Anti Cancer Activity of Pyrido[2,3-c]Pyridazine Derivatives [PDF]

Journal of Sciences, Islamic Republic of Iran, 2009
Cancer is not just one disease, but a large group of almost one hundred diseases. Its two main characteristics are uncontrolled growth of the cells in the human body and the ability of these cells to migrate from the original site and spread to distant ...
V. Kumar
doaj  

Synthesis of triazolopyridazine derivatives using iodobenzene diacetate and evaluation of their anticancer activity against MCF-7 breast cancer cells

Discover Chemistry
This study reports an efficient synthesis of 6-(4-methoxyphenyl)-3-aryl-[1,2,4]triazolo[4,3-b]pyridazine derivatives via oxidative cyclization of the corresponding hydrazones using iodobenzene diacetate as a mild and metal-free oxidizing agent.
Sandeep Malik, Rinku Soni, Monika Sihag, Neha Rani, Mayank Kinger, Monika Miglani, Deepak Kumar Aneja   +6 more
doaj   +1 more source

Development and validation of QSPR models for corrosion inhibition of carbon steel by some pyridazine derivatives in acidic medium. [PDF]

Heliyon, 2020
El Assiri EH, Driouch M, Lazrak J, Bensouda Z, Elhaloui A, Sfaira M, Saffaj T, Taleb M.   +7 more
europepmc   +1 more source

Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation. [PDF]

J Enzyme Inhib Med Chem, 2020
Elie J, Feizbakhsh O, Desban N, Josselin B, Baratte B, Bescond A, Duez J, Fant X, Bach S, Marie D, Place M, Ben Salah S, Chartier A, Berteina-Raboin S, Chaikuad A, Knapp S, Carles F, Bonnet P, Buron F, Routier S, Ruchaud S.   +20 more
europepmc   +1 more source

Polynitrogen Bicyclic and Tricyclic Compounds as PDE4 Inhibitors

Applied Sciences
We report here two new series of designed PDE4 inhibitors, the first one showing the quinoline scaffold recently investigated by us through a fragment-based drug design strategy, and the second consisting of pyrazolo [1′,5′:1,6]pyrimido[4,5-d]pyridazine ...
Claudia Vergelli, Agostino Cilibrizzi, Gabriella Guerrini, Fabrizio Melani, Marta Menicatti, Gianluca Bartolucci, Maria Paola Giovannoni, Letizia Crocetti   +7 more
doaj   +1 more source

Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors. [PDF]

ACS Med Chem Lett, 2019
Liu C, Lin J, Moslin R, Tokarski JS, Muckelbauer J, Chang C, Tredup J, Xie D, Park H, Li P, Wu DR, Strnad J, Zupa-Fernandez A, Cheng L, Chaudhry C, Chen J, Chen C, Sun H, Elzinga P, D'arienzo C, Gillooly K, Taylor TL, McIntyre KW, Salter-Cid L, Lombardo LJ, Carter PH, Aranibar N, Burke JR, Weinstein DS.   +28 more
europepmc   +1 more source

Targeting Acute Myeloid Leukemia with 1,2,4-triazolo[4,3-b]pyridazine derivatives: a molecular docking, dynamics, and ADMET approach. [PDF]

In Silico Pharmacol
Obakachi VA, Govender KK, Govender PP.
europepmc   +1 more source

Pyridazine-derivatives Enhance Structural and Functional Plasticity of Tripartite Synapse Via Activation of Local Translation in Astrocytic Processes. [PDF]

Neuroscience, 2018
Foster JB, Zhao F, Wang X, Xu Z, Lin K, Askwith CC, Hodgetts KJ, Lin CG.   +7 more
europepmc   +1 more source

Novel 3,6-Disubstituted Pyridazine Derivatives Targeting JNK1 Pathway: Scaffold Hopping and Hybridization-Based Design, Synthesis, Molecular Modeling, and In Vitro and In Vivo Anticancer Evaluation. [PDF]

ACS Omega
Shaalan MM, Osman EEA, Attia YM, Hammam OA, George RF, Naguib BH.   +5 more
europepmc   +1 more source

Design, synthesis, biological evaluation, and docking studies of novel triazolo[4,3-b]pyridazine derivatives as dual c-Met/Pim-1 potential inhibitors with antitumor activity. [PDF]

RSC Adv
Mahmoud ME, Ahmed EM, Ragab HM, Eltelbany RFA, Hassan RA.   +4 more
europepmc   +1 more source