Results 81 to 90 of about 2,698 (209)

Development of QSAR-based (MLR/ANN) predictive models for effective design of pyridazine corrosion inhibitors

, 2022
Twenty pyridazine derivatives with previously reported experimental data were utilized to develop predictive models for the anticorrosion abilities of pyridazine-based compounds.
Akpan, Ekemini D., Lee, Han-Seung, Lgaz, Hassane, Olasunkanmi, Lukman O., Quadri, Taiwo W., Verma, Chandrabhan, Fayemi, Omolola E.   +6 more
core   +1 more source

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

Reactivity and Synthetic Applications of 4,5-Dicyanopyridazine: An Overview

Molecules, 2010
Despite the poor reputation of electron-deficient pyridazines in intermolecular Hetero Diels-Alder (HDA) reactions, 4,5-dicyanopyridazine (DCP) showed a surprising reactivity as a heterocyclic azadiene in inverse electron-demand HDA processes with ...
Donatella Giomi, Marco Cecchi, Renzo Alfini   +2 more
doaj   +1 more source

Versatility of the pyridazine system: Chemistry and biology

, 2002
In accordance with the title of my lecture, I am going to briefly illustrate our researches on pyridazine derivatives active in different biological ...
G. Cignarella, D. Barlocco
core   +1 more source

Polysubstituted and ring-fused pyridazine systems from tetrafluoropyridazine [PDF]

, 2016
Tetrafluoropyridazine 1 reacts with a range of oxygen-, nitrogen-, sulfur- and carbon-centred nucleophiles to give, in general, products 2 arising from substitution of fluorine para to ring nitrogen.
Wilson, Ian, Yufit, Dmitrii S., Pattison, Graham, Sandford, G., Wilson, I., Howard, J.A.K., Sandford, Graham, Christopher, J.A., Yufit, D.S., Miller, D.D., Christopher, John A., Miller, David D., Pattison, G., Howard, Judith A.K.   +13 more
core   +1 more source

Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Pyridazine scaffolds are considered privileged structures pertaining to its novelty, chemical stability, and synthetic feasibility. In our quest towards the development of novel scaffolds for effective vascular endothelial growth 2 (VEGFR-2) inhibition ...
Maiy Y. Jaballah, Rabah A. T. Serya, Nasser Saad, Sohair M. Khojah, Marawan Ahmed, Khaled Barakat, Khaled A. M. Abouzid   +6 more
doaj   +1 more source

Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. [PDF]

ACS Med Chem Lett, 2023
Sun H, Du T, Yang M, Liu X, Xue X, Chen K, Lang X, Chen X, Wang B, Wang X.   +9 more
europepmc   +1 more source

Synthesis and Antimicrobial Activity of Some New Thieno[2,3-b]thiophene Derivatives

Molecules, 2013
A series of thieno[2,3-b]thiophene moiety-containing bis-cyanopyrazoles 5a–c, bis-aminopyrazole 9 and bis-pyridazine derivatives 11 were synthesized and evaluated in vitro for their antimicrobial potential.
Ahmad M. Farag, Nabila Abdelshafy Kheder, Yahia Nasser Mabkhot   +2 more
doaj   +1 more source

Pyridazine Derivatives as NLRP3 Inhibitors for Treating Asthma, COPD, Parkinson's Disease, and Alzheimer's Disease. [PDF]

ACS Med Chem Lett, 2023
Sabnis RW.
europepmc   +1 more source

Synthesis, Characterization and Biological Evaluation of Newer Chalcones by Microwave irradiation

To Chemistry Journal, 2020
Chalcones are a common natural pigment & one of the most important classes of flavonoids & iso-flavonoids across the whole edible plant kingdom. This α, β- unsaturated carbonyl is an important and versatile intermediate for the preparation of various ...
Shrikrishna Tupare, Rajendra P. Pawar
doaj