Results 101 to 110 of about 1,851 (175)

Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria. [PDF]

ACS Infect Dis
Snoke HE, Reeve SM, Dharuman S, Wallace MJ, Loudon VC, Zhao Y, Bowling JJ, Murphy PA, Waddell B, Lee RB, Bulitta JB, Lee RE.   +11 more
europepmc   +1 more source

Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M₄ Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust <i>In Vivo</i> Efficacy. [PDF]

ACS Chem Neurosci
Gregro AR, Park C, Long MF, Baker LA, Bollinger KA, Ringuette AE, Peng L, Luscombe VB, Billard NB, Rodriguez AL, Niswender CM, Peng W, Dickerson JW, Rook JM, O'Neill J, Chang S, Boonen HCM, Jensen T, Thomsen MS, Bridges TM, Boutaud O, Conn PJ, Engers DW, Lindsley CW, Temple KJ.   +24 more
europepmc   +1 more source

Shape-Conserving Atom Replacements. [PDF]

Chem Rev
Puriņš M, Elgindy C, Levin MD.
europepmc   +1 more source

Structure-Based Design, Synthesis, and Evaluation of Novel Ponatinib Derivatives With a Significantly Altered Selectivity Profile. [PDF]

ChemMedChem
Betzholz T, Liu T, Krämer A, Dederer V, Knapp S, Mathea S, Ducho C, Engel M.   +7 more
europepmc   +1 more source

Investigation of Anticancer Properties of Newly Synthesized Pyridazine-Based Inhibitors in Mouse and Human Breast Cancer Cell Line. [PDF]

Biology (Basel)
Coskun KA, Abay EC, Gumus M, Çelik AB, Gulum L, Koca I, Tutar Y.   +6 more
europepmc   +1 more source

Pyrazofurin Biosynthesis Involves Nonenzymatic Ring Contraction of a Pyridazine Intermediate Triggered by a Rieske Enzyme-Catalyzed Oxygenation. [PDF]

J Am Chem Soc
Zheng Z, Lee YH, Ren D, Liu HW.
europepmc   +1 more source

Triazenyl Furans as Diels-Alder Dienes. [PDF]

J Am Chem Soc
Budwitz JE, Hollers SA, Wester AR, Newton CG.   +3 more
europepmc   +1 more source

Therapeutic Potential of Tricyclic Pyridazinone-Based Molecules: An Overview. [PDF]

Int J Mol Sci
Asproni B, Pinna GA, Corona P, Coinu S, Piras S, Carta A, Murineddu G.   +6 more
europepmc   +1 more source

Photoinduced polarity-mismatched transformations of isoquinolines into naphthalenes. [PDF]

Nat Commun
Zhang C, Zhang J, Lan Y, Qin Y, Guo Z, Zhang W, Wang Q.   +6 more
europepmc   +1 more source

A Brand-New Metal Complex Catalyst-Free Approach to the Synthesis of 2,8-Dimethylimidazo[1,2-<i>b</i>]pyridazine-6-Carboxylic Acid-A Key Intermediate in Risdiplam Manufacturing Process. [PDF]

Molecules
Korenev G, Gutenev AA, Antipin FV, Chernyshov VV, Korobkina MP, Nawrozkij MB, Ivanov RA.   +6 more
europepmc   +1 more source