Results 101 to 110 of about 2,698 (209)

Screening and evaluation of antioxidant activity of some pyridazine derivatives

, 2008
Antioxidants are compounds that can delay, inhibit, or prevent the oxidation of materials that can be oxidized by scavenging free radicals and help in diminishing oxidative stress. They belong to different chemical classes.
Süzen, Sibel
core   +1 more source

Contribution to the chemical and pharmacological study of mono- bi- and tricyclic pyridazine derivatives

, 2014
La protéine kinase DYRK1A fait partie du groupe des CMGC kinases et est impliquée dans divers processus neurodégénératifs tels que la maladie d’Alzheimer.Dans ce cadre, une étude topologique a été menée autour d’un hit imidazo[1,2-B]pyridazine identifié ...
Blaise, Emilie
core  

Design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine derivatives as mTOR inhibitors

, 2017
ATP-competitive mTOR inhibitors have been studied as potential antitumor agents. Based on the structure-activity relationship of known mTOR inhibitors, a series of novel imidazo[1,2-b]pyridazine derivatives were synthesized and characterized.
Zhang, Lihe, Gao, Shanyun, Shanyun Gao, Yiran Weng, Beibei Mao, Lihe Zhang, Mao, Beibei, Zhang, Liangren, Weng, Yiran, Liangren Zhang   +9 more
core   +1 more source

Pyridazin-derivate. VI. Synthese der Derivate des Imidazo [1, 2-b] pyridazins

Chemical and Pharmaceutical Bulletin, 1964
Durch die Einwirkung von phenacylbromiden auf 3-Amino-6-chlorpyridazin wurden verschiedenartige 2-Phenyl-6-chlorimidazo [1, 2-b] pyridazine hergestellt. Das Chloratom der letzteren wurde durch Einwirkung von Na-Alkoholaten, Dialkylaminen bzw. wasr. alkoholischem Kali gegen Alkoxyl-, Dialkylamino- bzw. Hydroxyl-gruppen ausgetaus ht.
Yoneda, Fumio, Ohtaka, Takayuki, Nitta, Yoshihiro   +2 more
openaire   +2 more sources

Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity

, 2010
Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution.
Doğruer, Deniz Songül, Urlu, Soelen, Önkol, Tijen, Özçelik, Berrin, Sahin, M. Fethi   +4 more
core   +1 more source

Synthesis and Biological Activity of Pyridopyridazine Derivatives: A Mini Review

, 2018
This review presents most of the literature data about synthesis and biological activity of pyridopyridazine derivatives. There are six structural isomers of the bicyclic ring system containing pyridine moiety condensed with pyridazine nucleus ...
Anna Wojcicka, Anna Nowicka-Zuchowska
core   +1 more source

Development and validation of QSPR models for corrosion inhibition of carbon steel by some pyridazine derivatives in acidic medium. [PDF]

Heliyon, 2020
El Assiri EH, Driouch M, Lazrak J, Bensouda Z, Elhaloui A, Sfaira M, Saffaj T, Taleb M.   +7 more
europepmc   +1 more source

Synthesis of Pyridazine Derivatives Through the Unexpected Intermediate 5‐Amino‐4‐cyano‐2,3‐dihydro‐furan‐2,3‐disulfonic Acid Disodium Salt.

, 2003
An unexpected compound (5-amino-4-cyano-2,3-dihydrofuran-2,3-disulfonic acid disodium salt, 4) was isolated from the reaction of glyoxale bis hydrogen sulfite disodium salt with malononitrile.
Giampiero Spalluto, Valeria Ferretti, FERRETTI, Valeria, Barbara Cacciari, SPALLUTO G, CACCIARI, Barbara   +5 more
core   +1 more source

Polynitrogen Bicyclic and Tricyclic Compounds as PDE4 Inhibitors

Applied Sciences
We report here two new series of designed PDE4 inhibitors, the first one showing the quinoline scaffold recently investigated by us through a fragment-based drug design strategy, and the second consisting of pyrazolo [1′,5′:1,6]pyrimido[4,5-d]pyridazine ...
Claudia Vergelli, Agostino Cilibrizzi, Gabriella Guerrini, Fabrizio Melani, Marta Menicatti, Gianluca Bartolucci, Maria Paola Giovannoni, Letizia Crocetti   +7 more
doaj   +1 more source

Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation. [PDF]

J Enzyme Inhib Med Chem, 2020
Elie J, Feizbakhsh O, Desban N, Josselin B, Baratte B, Bescond A, Duez J, Fant X, Bach S, Marie D, Place M, Ben Salah S, Chartier A, Berteina-Raboin S, Chaikuad A, Knapp S, Carles F, Bonnet P, Buron F, Routier S, Ruchaud S.   +20 more
europepmc   +1 more source