Results 121 to 130 of about 1,851 (175)

Iptycene-Derived Pyridazines and Phthalazines

The Journal of Organic Chemistry, 2007
The synthesis of new heterocyclic oligo(phenylene) analogues based on soluble, nonaggregating 1,2-diazines is reported. Improved palladium-catalyzed reductive coupling methods were developed to allow for the preparation of large quantities of iptycene-derived bipyridazines and biphthalazines, and the controlled synthesis of well-defined oligomers up to
Jean, Bouffard, Robert F, Eaton, Peter, Müller, Timothy M, Swager   +3 more
openaire   +2 more sources

Pyridazine-derived γ-secretase modulators

Bioorganic & Medicinal Chemistry Letters, 2011
SAR of a novel series of pyridazine-derived γ-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain the levels of total Aβ. Furthermore, 25 demonstrated excellent pharmacokinetic parameters as well as good CNS penetration in the rat.
Zehong, Wan, Adrian, Hall, Yun, Jin, Jia-Ning, Xiang, Eric, Yang, Andrew, Eatherton, Beverley, Smith, Guang, Yang, Haihua, Yu, Ju, Wang, Liang, Ye, Lit-Fui, Lau, Ting, Yang, William, Mitchell, Wei, Cai, Xiaomin, Zhang, Yingxia, Sang, Yonghui, Wang, Zhaolong, Tong, Ziqiang, Cheng, Ishrut, Hussain, John D, Elliott, Yasuji, Matsuoka   +22 more
openaire   +2 more sources

Synthesis of α‐(Trifluoromethyl)pyridazine Derivatives

European Journal of Organic Chemistry, 2018
Over the last decades, an increasing interest in α‐(trifluoromethyl)pyridazines in medicinal chemistry has been noticed. This interest stems firstly from the recent development of biologically active pyridazines as well as from the capacity of the pyridazine ring to be a bioisoster of other heterocycles.
Feraldi-Xypolia, Alexandra, Gomez Pardo, Domingo, Cossy, Janine   +2 more
openaire   +2 more sources

Pyridazine Derivatives, VII. Synthesis and Hypotensive Activity of 3‐Hydrazinocycloalkyl[1,2‐c]pyridazines and their Derivatives

Archiv der Pharmazie, 1989
AbstractThe preparation of a series of 3‐hydrazinocycloalkyl[1,2‐c]‐pyridazines 7 and some derivatives as hydrazones 8, 9, triazoles 10 and pyrroles 11 are described together with their hypotensive activity in normotensive rats.
C, Terán, E, Raviña, L, Santana, N, García-Domínguez, G, García-Mera, J A, Fontenla, F, Orallo, J M, Calleja   +7 more
openaire   +2 more sources

Neue Derivate des Pyridazins

Journal für Praktische Chemie, 1969
AbstractDas neuerdings leicht zugängliche 3‐Amino‐4‐hydroxy‐6‐methy1‐pyridazin 1 [1] erschließt einen neuen Zugang zu Derivaten des Pyridazins. Die Umsetzung mit salpetriger Säure liefert in verdünnter Schwefelsäure 3,4‐Dihydroxy‐6‐methyl‐pyridazin 3, in konz. Salzsäure dagegen 3‐Chlor‐4‐hydroxy‐6‐methylpyridazin 2.
H. G. O. Becker, H. Böttcher, J. Koch
openaire   +1 more source

Synthesis of pyridazine derivatives—XXVIII

Tetrahedron, 1967
B. Stanovnik, M. Tišler
openaire   +1 more source

Pyridazines and their Benzo Derivatives

2008
Maes, B.U.W., Lemière, G.L.F.
openaire   +2 more sources

Design, synthesis and biological activity of chalcone derivatives containing pyridazine

Arabian Journal of Chemistry, 2023
Yong-Jun Wu, Shuang Feng, Bangcan He
exaly  

Pyridazines and Their Benzo Derivatives

2022
Gary Chinigo, Yiqing Feng, Susan Hoy, Ricardo Lira, Matthew Perry   +4 more
openaire   +1 more source

Pyridazine derivatives as selective COX‐2 inhibitors: A review on recent updates

Drug Development Research, 2023
Rasha Ahmed Hassan, Marwa Hassan
exaly