Results 61 to 70 of about 1,851 (175)

Reactivity and Synthetic Applications of 4,5-Dicyanopyridazine: An Overview

Molecules, 2010
Despite the poor reputation of electron-deficient pyridazines in intermolecular Hetero Diels-Alder (HDA) reactions, 4,5-dicyanopyridazine (DCP) showed a surprising reactivity as a heterocyclic azadiene in inverse electron-demand HDA processes with ...
Donatella Giomi, Marco Cecchi, Renzo Alfini   +2 more
doaj   +1 more source

Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. [PDF]

ACS Med Chem Lett, 2023
Sun H, Du T, Yang M, Liu X, Xue X, Chen K, Lang X, Chen X, Wang B, Wang X.   +9 more
europepmc   +1 more source

Syntheses of Pyridazine Derivatives as Herbicides

Agricultural and Biological Chemistry, 1968
Series of 3-chloro-6-phenoxy- and 3,6-bisphenoxypyridazines were prepared from 3,6-dichloropyridazine to be evaluated as herbicides. Certain thioethers were also prepared.
Teruomi JOJIMA, Kozo OYAMADA, Saburo TAMURA   +2 more
openaire   +2 more sources

Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Pyridazine scaffolds are considered privileged structures pertaining to its novelty, chemical stability, and synthetic feasibility. In our quest towards the development of novel scaffolds for effective vascular endothelial growth 2 (VEGFR-2) inhibition ...
Maiy Y. Jaballah, Rabah A. T. Serya, Nasser Saad, Sohair M. Khojah, Marawan Ahmed, Khaled Barakat, Khaled A. M. Abouzid   +6 more
doaj   +1 more source

Synthesis and Antimicrobial Activity of Some New Thieno[2,3-b]thiophene Derivatives

Molecules, 2013
A series of thieno[2,3-b]thiophene moiety-containing bis-cyanopyrazoles 5a–c, bis-aminopyrazole 9 and bis-pyridazine derivatives 11 were synthesized and evaluated in vitro for their antimicrobial potential.
Ahmad M. Farag, Nabila Abdelshafy Kheder, Yahia Nasser Mabkhot   +2 more
doaj   +1 more source

Pyridazine Derivatives as NLRP3 Inhibitors for Treating Asthma, COPD, Parkinson's Disease, and Alzheimer's Disease. [PDF]

ACS Med Chem Lett, 2023
Sabnis RW.
europepmc   +1 more source

Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping. [PDF]

J Med Chem, 2023
Břehová P, Řezníčková E, Škach K, Jorda R, Dejmek M, Vojáčková V, Šála M, Kovalová M, Dračínský M, Dolníková A, Strmeň T, Kinnertová M, Chalupský K, Dvořáková A, Gucký T, Mertlíková Kaiserová H, Klener P, Nencka R, Kryštof V.   +18 more
europepmc   +1 more source

Pyrrolo-pyridazine Derivatives as Muscarinic M₁ Receptor Positive Allosteric Modulators. [PDF]

ACS Med Chem Lett, 2021
Blass BE.
europepmc   +1 more source

Facile Synthesis and Antimicrobial Evaluation of Some New Heterocyclic Compounds Incorporating a Biologically Active Sulfamoyl Moiety

The Scientific World Journal, 2014
A facile and convenient synthesis of new heterocyclic compounds containing a sulfamoyl moiety suitable for use as antimicrobial agents was reported. The precursor 3-oxo-3-phenyl-N-(4-sulfamoylphenyl)propionamide was coupled smoothly with arenediazonium ...
Elham S. Darwish
doaj   +1 more source

Synthesis, Anticancer Activities and Molecular Docking Studies of a Novel Class of 2-Phenyl-5,6,7,8-tetrahydroimidazo [1,2-b]pyridazine Derivatives Bearing Sulfonamides. [PDF]

Molecules, 2022
Bourzikat O, El Abbouchi A, Ghammaz H, El Brahmi N, El Fahime E, Paris A, Daniellou R, Suzenet F, Guillaumet G, El Kazzouli S.   +9 more
europepmc   +1 more source