Results 21 to 30 of about 2,698 (209)

Pyridazine: A Magical Moiety

, 2022
Introduction: A heterocyclic organic molecule having the chemical formula, C4H4N2. It is aromatic and has a 6-membered ring with two nearby nitrogen atoms. It has a specific heat of 208 °C and is an inert liquid. This paper presents a complete summary of
Jyoti, ., Sharma, Bhartendu, Akhilesh, ., Mishra, Ravinesh, Bali, Yashsavi   +4 more
core   +1 more source

Heterocyclic synthesis with nitriles: synthesis of pyridazine and pyridopyridazine derivatives [PDF]

, 2007
The reaction of MND with aryldiazonium chlorides followed by cyclization afforded the pyridazinimine derivatives. Reaction of the latter with another mole of malononitrile produce only pyrido[3,2-c]pyridazine derivatives.
Campos, Ana M. F. Oliveira, Abdellatif Salaheldin, Rodrigues, Lígia M., Lígia Rodrigues, Ana Oliveira-Campos, Salaheldin, Abdellatif M.   +5 more
core   +1 more source

Electrochemical, DFT and Mont Carlo Simulations Studies to Evaluate the Inhibition Effect of Novel Pyridazine Derivatives on Iron Pitting Corrosion in 3.5 % NaCl

International Journal of Electrochemical Science, 2018
(6-Phenyl-pyridazin-3-ylsulfanyl)-acetic acid ethyl ester (PPS-A) and 4-(6-Phenyl-pyridazin-3-ylsulfanyl)-butyric acid ethyl ester (PPS-B) are synthesized and characterized as novel S-alkylated pyridazine derivatives with different side chain lengths ...
M.M. El-Deeb, N.S. Abdel-Shafi, A.H. Shamroukh   +2 more
doaj   +1 more source

Synthesis and Antimicrobial Activities of Some New Heterocyclic Compounds Based on 6-Chloropyridazine-3(2H)-thione

Journal of Chemistry, 2013
Three tricyclic ring system, pyridazino[6,1-b]quinazolin-10-ones, benzimidazolo-pyridazine thione, and 1,2,4-benzotriazino-pyridazinethione along with imidazo-[1,2-b]-pyridazinethione, 1,2,4-triazolo[4,3-b]pyridazine-thione derivatives were synthesized ...
Nasser M. Abd El-Salam, Mohamed S. Mostafa, Gamal A. Ahmed, Othman Y. Alothman   +3 more
doaj   +1 more source

Microwave-Assisted One Pot Three-Component Synthesis of Novel Bioactive Thiazolyl-Pyridazinediones as Potential Antimicrobial Agents against Antibiotic-Resistant Bacteria

Molecules, 2021
Pyridazine and thiazole derivatives have various biological activities such as antimicrobial, analgesic, anticancer, anticonvulsant, antitubercular and other anticipated biological properties.
Sraa Abu-Melha, Sobhi M. Gomha, Amr S. Abouzied, Mastoura M. Edrees, Ahmed S. Abo Dena, Zeinab A. Muhammad   +5 more
doaj   +1 more source

A study on synthesis and antimicrobial activity of 4-acyl-pyrazoles

Journal of Saudi Chemical Society, 2018
4-Acyl-pyrazole-3-carboxylic acids (1) were synthesized via the reaction of 4-acyl-2,3-furandiones (F) with hydrazone (1-benzylidene-2-(2,5-dimethyl-phenyl)-hydrazine) by heating under solid phase and their acid chlorides (2) were obtained.
Adnan Çetin, İshak Bildirici
doaj   +1 more source

Safe Synthesis of 4,7-Dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine and Its SNAr Reactions

Molecules, 2018
A safe and efficient synthesis of 4,7-dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine from the commercial diaminomaleonitrile is reported. Conditions for selective aromatic nucleophilic substitution of one or two bromine atoms by oxygen and nitrogen ...
Timofey N. Chmovzh, Ekaterina A. Knyazeva, Konstantin A. Lyssenko, Vadim V. Popov, Oleg A. Rakitin   +4 more
doaj   +1 more source

Caspase-3 activities and androgen receptor expression in rats’ testis during the early biochemical and histopathological changes induced by a carcinogen, Diethylnitrosamine: role of probiotics and pyridazine derivatives [PDF]

Egyptian Journal of Cancer and Biomedical Research, 2021
Background: Diethylnitrosamine (DENA) is a common environmental toxicant with  a well-known hepatocarcinogenic potential. Aim: The current study aimed to: 1) investigate the carcinogenic toxicity of DENA on the rats’ testis, 2) to elucidate the role of ...
Ahmed Morsi, Sahar Ahmed, Neveen Saleh, Rania Abd El-Aal, Tamer El Malah, Asmaa Elsayed   +5 more
doaj   +1 more source

Pyridazine Derivatives. IV. The Structures of Aminopyridazines.

Chemical and Pharmaceutical Bulletin, 1963
The infrared absorption spectra of the two aminopyridazines were observed and compared with those of the three aminopyridines and aniline. The amino-form of the two aminopyridazines was confirmed, and at the same time the structural similarity of 4-aminopyridazine with 4-aminopyridine was shown by their infrared spectra.
Nitta, Yoshihiro, Tomii, Reiko, Yoneda, Fumio   +2 more
openaire   +3 more sources

Pyridine C─N Transposition via Cycloaddition–Cycloreversion

Angewandte Chemie, EarlyView.
Transposition of pyridine nitrogen from the 4‐ to the 3‐position is described using two open and shut sequences: a nucleophile addition ring‐open ring‐closure, followed by a nitrile Diels–Alder cycloaddition cycloreversion. The nitrogen swap is particularly effective for tertiary alkyl substituents, transforming easily accessible para‐alkylated ...
Aífe Conboy, Michael F. Greaney
wiley   +2 more sources