Results 11 to 20 of about 1,851 (175)
International Journal of Electrochemical Science, 2018 (6-Phenyl-pyridazin-3-ylsulfanyl)-acetic acid ethyl ester (PPS-A) and 4-(6-Phenyl-pyridazin-3-ylsulfanyl)-butyric acid ethyl ester (PPS-B) are synthesized and characterized as novel S-alkylated pyridazine derivatives with different side chain lengths ...
M.M. El-Deeb +2 more
doaj +1 more source
Strategy for the Synthesis of Pyridazine Heterocycles and Their Derivatives [PDF]
The Journal of Organic Chemistry, 2013 The first synthesis of novel fused pyridazines has been realized starting from 1,3-diketones involving a Diaza-Wittig reaction as a key step. A convenient strategy was elaborated to access versatile pyridazine derivatives allowing the variation of substituents at position 6 of the heterocyclic ring.
Belabed, Hassen +4 more
openaire +3 more sources
Journal of Chemistry, 2013 Three tricyclic ring system, pyridazino[6,1-b]quinazolin-10-ones, benzimidazolo-pyridazine thione, and 1,2,4-benzotriazino-pyridazinethione along with imidazo-[1,2-b]-pyridazinethione, 1,2,4-triazolo[4,3-b]pyridazine-thione derivatives were synthesized ...
Nasser M. Abd El-Salam +3 more
doaj +1 more source
Molecules, 2021 Pyridazine and thiazole derivatives have various biological activities such as antimicrobial, analgesic, anticancer, anticonvulsant, antitubercular and other anticipated biological properties.
Sraa Abu-Melha +5 more
doaj +1 more source
A study on synthesis and antimicrobial activity of 4-acyl-pyrazoles
Journal of Saudi Chemical Society, 2018 4-Acyl-pyrazole-3-carboxylic acids (1) were synthesized via the reaction of 4-acyl-2,3-furandiones (F) with hydrazone (1-benzylidene-2-(2,5-dimethyl-phenyl)-hydrazine) by heating under solid phase and their acid chlorides (2) were obtained.
Adnan Çetin, İshak Bildirici
doaj +1 more source
Angewandte Chemie, EarlyView.Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee +5 more
wiley +2 more sources
Safe Synthesis of 4,7-Dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine and Its SNAr Reactions
Molecules, 2018 A safe and efficient synthesis of 4,7-dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine from the commercial diaminomaleonitrile is reported. Conditions for selective aromatic nucleophilic substitution of one or two bromine atoms by oxygen and nitrogen ...
Timofey N. Chmovzh +4 more
doaj +1 more source
Caspase-3 activities and androgen receptor expression in rats’ testis during the early biochemical and histopathological changes induced by a carcinogen, Diethylnitrosamine: role of probiotics and pyridazine derivatives [PDF]
Egyptian Journal of Cancer and Biomedical Research, 2021 Background: Diethylnitrosamine (DENA) is a common environmental toxicant with a well-known hepatocarcinogenic potential. Aim: The current study aimed to: 1) investigate the carcinogenic toxicity of DENA on the rats’ testis, 2) to elucidate the role of ...
Ahmed Morsi +5 more
doaj +1 more source
Iridium‐Catalyzed Ionic Hydrogenation of Multi‐Aza Heterocycles
Angewandte Chemie, EarlyView.Saturated nitrogen‐containing heterocycles are ubiquitous in bioactive molecules and are thus attractive synthetic targets. A readily accessible cyclometalated iridium(III) complex reduces 14 different aromatic aza heterocycles to (partially)saturated multi aza‐heterocycles enlarging accessible chemical space while displaying high tolerance toward ...
Arthur Despois, Nicolai Cramer
wiley +2 more sources
Construction of Unusual Indole-Based Heterocycles from Tetrahydro-1H-pyridazino[3,4-b]indoles
Molecules, 2020 Herein, we report the successful syntheses of scarcely represented indole-based heterocycles which have a structural connection with biologically active natural-like molecules.
Cecilia Ciccolini +5 more
doaj +1 more source