Pyridazine Derivatives. XI: Antihypertensive Activity of 3-Hydrazinocycloheptyl[1,2-c]pyridazine and Its Hydrazone Derivatives [PDF]
Journal of Pharmaceutical Sciences, 1993 3-Hydrazinocycloheptyl[1,2-c]pyridazine (4) and its hydrazone derivatives 3-[N1-(isopropylidene)]hydrazinocycloheptyl[1,2-c]pyridazine [correction of hydrazinocyclohexyl] (5) and 3-[N1-(isobutylidene)]hydrazinocycloheptyl[1,2-c]pyridazine (6) were prepared, and their activity against genetic, neurogenically-induced, and deoxycorticosterone acetate ...
Gil-Longo, José +8 more
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Molecular docking studies of N-substituted 4-methoxy-6-oxo-1-aryl-pyridazine-3-carboxamide derivatives as potential modulators of glutamate receptors [PDF]
Research Results in Pharmacology, 2020 Introduction: The virtual target-oriented screening is a necessary stage of modern drug-design. In the present study, the affinity of pyridazine derivatives for the most promising antiparkinsonian biotargets – I–III groups of metabotropic and ionotropic ...
Hanna I. Severina +5 more
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Electrochemical and Spectroscopic Studies of Pyridazine Derivatives [PDF]
Portugaliae Electrochimica Acta, 2004 This work reports on cyclic voltammetry and spectroscopic UV-Vis investigations of some pyridazine derivatives 1-8 in dimethylformamide. In the electrochemical study, monochlorinated pyridazines 2-8 exhibit two reductions but in the case of dichlorinated derivative 1 an additional wave is seen for the reduction of the second carbon-chloride bond.
Vieira,L.M.C. +3 more
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An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives
Beilstein Journal of Organic Chemistry, 2009 The reaction of 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide with tertiary butyl carbazate and subsequent condensation of the resulting carbamate derivative with a chalcone provided a facile new approach to pyrrolo[
Rajeshwar Reddy Sagyam +5 more
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The Reaction of Cyclopentanone with Cyanomethylene Reagents: Novel Synthesis of Pyrazole, Thiophene, and Pyridazine Derivatives [PDF]
Journal of Chemistry, 2013 The reaction of cyclopentanone with either malononitrile or ethyl cyanoacetate gave the corresponding condensated products. The latter underwent some heterocyclic reactions to give new pyrazole, thiophene, and pyridazine derivatives.
Wagnat W. Wardakhan, Eman M. Samir
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Journal of Saudi Chemical SocietyIn this manuscript, we are motivated to investigate the reaction site-selectivity for the hydrazo thiazole derivatives (6a–c) with different types of active methylene groups such as malononitrile, and ethyl cyanoacetate.
Fuad A. Alatawi +7 more
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Molecules, 2021 During the last few decades, pyridazine derivatives have emerged as privileged structures in heterocyclic chemistry, both because of their excellent chemistry and because of their potential applications in medicinal chemistry and optoelectronics.
Dorina Amariucai-Mantu +2 more
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USES OF 4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE IN THE SYNTHESIS OF PYRIDAZINE, PYRAZOLE, THIAZOLE AND PYRIMIDINE DERIVATIVES TOGETHER WITH THEIR CYTOTOXICITY [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2014 The reaction of N-phenylbutanamide derivative 1 with bromine afforded compound 2 which it was directed to reacts with activated methylene groups, malononitrile (3a) and ethylcyanoacetae (3b) to produce compounds 4a and 4b respectively, on the other hand ...
Karam El-Sharkawy
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Syntheses of Pyridazine Derivatives as Herbicides [PDF]
Agricultural and Biological Chemistry, 1968 Series of 3-chloro-6-phenoxy- and 3,6-bisphenoxypyridazines were prepared from 3,6-dichloropyridazine to be evaluated as herbicides. Certain thioethers were also prepared.
Teruomi JOJIMA +2 more
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Synthesis of some pyridazine derivatives as antioxidants and antimicrobial agents
, 2021 Purpose: To prepare some pyridazine derivatives as antioxidant and antimicrobial agents. Methods: The coupling of aryl diazonium salts with diethyl 2-cyano-3-methylglutaconate afforded pyridazine-5-carbonitrile derivatives (3a-e).
Diwan, Anupama +3 more
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