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Zinc-Enabled Annulation of Trifluorodiazoethane with 2H-Azirines to Construct Trifluoromethyl Pyrazolines, Pyrazoles, and Pyridazines.

Organic Letters, 2021
A diethylzinc-promoted unconventional annulation reaction of 2,2,2-trifluorodiazoethane with 2H-azirines is described. This transformation involves two [3 + 2] cycloaddition steps and one dinitrogen extrusion process in one pot, thus giving a broad array
Yuefeng Chen   +2 more
semanticscholar   +1 more source

TBAI/K2S2O8-Promoted [4 + 2] Annulation of Ketene N,S-Acetals and N-Tosylhydrazones toward Pyridazines.

Organic Letters, 2021
A TBAI/K2S2O8-promoted [4 + 2] annulation of ketene N,S-acetals, and N-tosylhydrazones was efficiently developed, enabling straightforward access to a variety of trisubstituted pyridazines in reasonable to good yields.
Zhuqing Liu, Jiang Lou, Jiaqi Xiao
semanticscholar   +1 more source

One-Pot and Two-Chamber Methodologies for Using Acetylene Surrogates in the Synthesis of Pyridazines and Their D-Labeled Derivatives.

Chemistry - An Asian Journal, 2021
Acetylene surrogates are efficient tools in modern organic chemistry with largely unexplored potential in the construction of heterocyclic cores. Two novel synthetic paths to 3,6-disubstituted pyridazines were proposed using readily available acetylene ...
M. Ledovskaya   +2 more
semanticscholar   +1 more source

A concise and focused overview upon arylglyoxal monohydrates-based one-pot multi-component synthesis of fascinating potentially biologically active pyridazines

Journal of Molecular Structure, 2021
Pyridazine derivatives are a consequential class of heterocyclic compounds, which expose a wide range of distinguished biological activities. For example, pyridazine scaffolds are known as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (
Hossein Mousavi
semanticscholar   +1 more source

Antimicrobial Pyridazines: Synthesis, Characterization, Cytotoxicity, Substrate Promiscuity, and Molecular Docking

Chemistry and Biodiversity, 2020
A facile and convenient synthesis of new pyridazines suitable for use as antimicrobial agents was reported. The hydrazide intermediate was coupled with various benzaldehydes and/or acetophenones and cyclized instantaneously to afford target pyridazine ...
Muhamad Mustafa, Yaser A. Mostafa
semanticscholar   +1 more source

Pyridazines

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
N. Haider, W. Holzer
openaire   +1 more source

Vibrational spectra of pyridazine, pyridazine-d4, pyridazine-3,6-d2 and pyridazine-4,5-d2

Spectrochimica Acta Part A: Molecular Spectroscopy, 1967
Abstract Infrared spectra of the liquids pyridazine, pyridazine- d 4 and pyridazine-3,6- d 2 are reported from 270 to 4,000 cm −1 . Raman spectra are reported for these liquids with the state of polarization for many lines. The vibrational assignment suggested for these three compounds satisfies the three Teller—Redlich product rules within ...
H.D. Stidham, J.V. Tucci
openaire   +1 more source

Novel tribenzylaminobenzolsulphonylimine based on their pyrazine and pyridazines: Synthesis, characterization, antidiabetic, anticancer, anticholinergic, and molecular docking studies.

Bioorganic chemistry (Print), 2019
A new method of obtaining multifunctional pyrazoles by the reaction of 1,3-dipolar addition of tribenzylsulfonyliminochloride to polarophiles has been developed. This imine is obtained by reacting tribenzylamine with N-chlorobenzene sulfamide (chloramine-
G. Mamedova   +10 more
semanticscholar   +1 more source

SYNTHESIS OF NEW PYRIDAZIN- 6-ONES, PYRIDAZIN-6-IMINES, 4-PYRIDAZINALS, AND PYRIDINES

Synthetic Communications, 2002
ABSTRACT 3-Dimethyl-1-[3-methyl-(4H)-5-phenylimidazol[2,1-b]thiazol-2-yl]prop-2-enone 4 couples smoothly with benzenediazonium chloride to yield propanal 5 which is a key intermediate for the synthesis of pyridazinones 9–13, 16 and pyridazine-6-imine 8, 19.
Samia Sayed   +3 more
openaire   +1 more source

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