Results 141 to 150 of about 10,186 (207)

Inverse-Electron-Demand Diels-Alder Reactions for the Synthesis of Pyridazines on DNA.

Organic Letters, 2018
The synthesis of pyridazines on DNA has been developed on the basis of inverse-electron-demand Diels-Alder (IEDDA) reactions of 1,2,4,5-tetrazines. The broad substrate scope is explored.
Hailong Li, Zhen Sun, Wenting Wu, Xuan Wang, Mingqiang Zhang, Xiaojie Lu, W. Zhong, Dongcheng Dai   +7 more
semanticscholar   +1 more source

Pyridazines. III. The synthesis of substituted pyridazines

Journal of Heterocyclic Chemistry, 1965
AbstractA series of pyridazines and pyridazones have been prepared substituted with alkyl, alkoxyl, halogen, mercapto, substituted mercapto, phenyl, morpholino, piperidino, styryl, substituted styryl and pyridylethenyl groups as potential antitumor agents. The compounds possessing antitumor or tissue culture activity are recorded in Table VI.
Raymond N. Castle, Kenji Kaji
openaire   +1 more source

Copper-Catalyzed Aerobic 6-Endo-Trig Cyclization of β,γ-Unsaturated Hydrazones for the Divergent Synthesis of Dihydropyridazines and Pyridazines.

Journal of Organic Chemistry, 2019
A divergent synthetic strategy to 1,6-dihydropyridazines and pyridazines through Cu(II)-catalyzed controllable aerobic 6-endo-trig cyclization was developed. The selectivity can be rationally tuned via the judicious choice of reaction solvent.
Zhenwei Fan, Zhangjin Pan, Liangsen Huang, Jiajia Cheng   +3 more
semanticscholar   +1 more source

Switchable Ring-Contractive Extrusion Reactions of 2,5-Dihydro-1,4,5-thiadiazepine S-Oxides: Entries to Pyridazines or Pyrazoles.

Journal of Organic Chemistry, 2019
Switchable ring-contractive extrusion reactions of 2,5-dihydro-1,4,5-thiadiazepine S-oxides are described, which allow expedient access to pyridazines under thermal conditions or pyrazoles under Lewis acid-mediated conditions, respectively.
Bin Cheng, Yuntong Li, Hui Li, Xinping Zhang, Taimin Wang, Yun Li, H. Zhai   +6 more
semanticscholar   +1 more source

Imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1 decrease the parasite burden in mice with acute toxoplasmosis.

International Journal of Parasitology, 2018
The current therapeutic arsenal for toxoplasmosis is restricted to drugs non-specific to the parasite which cause important side effects. Development of more efficient and specific anti-Toxoplasma compounds is urgently needed.
Espérance Moine, N. Moiré, I. Dimier-Poisson, K. Brunet, W. Couet, C. Colas, N. Van Langendonck, C. Enguehard-Gueiffier, A. Gueiffier, Bruno Héraut, Caroline Denevault-Sabourin, F. Debierre-Grockiego   +11 more
semanticscholar   +1 more source

ChemInform Abstract: Synthesis of Pyridazine and Fused Pyridazine.

ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
M. G. ASSY, E. A. EL‐GHANI
openaire   +1 more source

Pyridazines. LXXXIV. Studies on borohydride reduction of pyridazine compounds

Journal of Heterocyclic Chemistry, 1976
AbstractImidazo[1,2‐b]pyridazine, s‐triazolo[4,3‐b]pyridazine and tetrazolo[1,5‐b]pyridazine and some derivatives thereof were reduced with sodium borohydride to give the corresponding 5,6,7,8‐tetrahydro derivatives. A mechanism for these reductions is proposed and reduction at the C7‐C8 bond occurs before the reduction of the C6N5 bond.
P. K. Kadaba, B. Stanovnik, M. Tišler
openaire   +1 more source

ChemInform Abstract: PYRIDAZINE 37. MITT. PYRIMIDO(1,2‐B)PYRIDAZINE

Chemischer Informationsdienst. Organische Chemie, 1971
Abstract3‐Amino‐pyridazine (I) reagieren mit Acetessigestern (II) über die Zwischenstufen (III) beim Erhitzen in Polyphosphorsäure zu den Pyrimido(l ,2‐b)′‐′‐ pyridazin‐2‐onen (IV); der Grundkörper (IV) (R1 = CH3, R2 = H) kann auch mit Diketen (V) direkt erhalten werden.
A. POLLAK, B. STANOVNIK, M. TISLER
openaire   +1 more source

Pyridazines. XXIII. A novel pyridazine into pyrazole ring transformation

Journal of Heterocyclic Chemistry, 1984
AbstractTreatment of phenyl(4‐pyridazinyl)methanols 1a and 1b with p‐toluenesulfonic acid at elevated temperatures causes transformation into the C‐4 substituted pyrazole derivatives 8a and 8b. Limitations of this novel rearrangement reaction as well as mechanistic considerations are discussed.
Gottfried Heinisch, Richard Waglechner
openaire   +1 more source

ChemInform Abstract: Synthesis of New Pyridazin‐6‐ones, Pyridazin‐6‐imines, 4‐Pyridazinals, and Pyridines.

ChemInform, 2002
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Samia M. Sayed, Mohamed A. Khalil, Maghraby A. Ahmed, Mohamed A. Raslan   +3 more
openaire   +1 more source