Results 201 to 210 of about 51,809 (295)

Convergent Synthesis of Tetradentate Aminopyridine C-H Oxidation Catalysts. [PDF]

ACS Org Inorg Au
Lu Y, Anisovich K, Tiefenbacher K.
europepmc   +1 more source

Characterization of the Orphan Cytochrome P450 CYP107J1 From Bacillus subtilis Through Peroxygenase Activity Engineering

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
The orphan cytochrome P450 CYP107J1 with unknown redox partners was rationally modified into H2O2‐driven form. The QE (E251Q/T252E) mutant produced valuable chemicals by simply mixing the enzyme with substrate and H2O2. ABSTRACT Cytochrome P450 monooxygenases (P450s) not only play many physiological roles in oxidative metabolism but are also promising ...
Hideki Kato, Takafumi Hashimoto, Tuhin Das, Daniel Z. Doherty, Stephen G. Bell, Toshiki Furuya   +5 more
wiley   +1 more source

One-Pot Bioisosteric Replacement of Alkyl Carboxylic Acids via Organic Photoredox Catalysis. [PDF]

Org Lett
Haney BA, Merriman MT, Qian S, Nicewicz DA.   +3 more
europepmc   +1 more source

Discovery of [1,2,4]triazolo[1,5‐a]pyrimidine‐Imatinib Hybrids With Selective Cytotoxic Activity: A Mechanistically Divergent Series From Direct BCR‐ABL1 Inhibition

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Discovery of imatinib–triazolopyrimidine hybrids with selective cytotoxicity and a mechanism distinct from classical BCR‐ABL1 inhibition. This bioisosteric strategy introduces a novel compounds, paving the way for innovative antileukemic therapies with differentiated profiles.
Stefany Castro Bazan Moura, Andressa Paula de Oliveira, Joao de Mello Rezende Neto, Rafael Ferreira Dantas, Floriano Paes Silva‐Jr, Luiz Claudio Pimentel, Mayara Salles do Nascimento Carvalho, Debora Inacio Leite, Daiane Vitoria da Silva, Monica Macedo Bastos, Nubia Boechat   +10 more
wiley   +1 more source

The efficacy of sodium hexafluoroaluminate (cryolite) for direct amidation of carboxylic acids. [PDF]

RSC Adv
Singh AG, Briere J, VanDer Kamp J, Ramachandran PV.   +3 more
europepmc   +1 more source

Elucidating the Solvent‐Dependent Solvation and Structural Stability of Irinotecan: A Molecular Simulation Study

ChemPhysChem, Volume 27, Issue 8, 28 April 2026.
The solvation preference of irinotecan is governed by a competition between cavity formation and electrostatic stabilization. Computations reveal that the high cost of breaking water's hydrogen bond network outweighs its electrostatic benefits. In contrast, polar aprotic solvents (e.g., pyridine) offer an optimal thermodynamic balance, providing strong
Martin M. Bitabo, Sixberth Mlowe, Daniel M. Shadrack, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source

Second‐Generation Crystalline Sponges Enabling Consistent Structure Analysis Under Standardized Conditions for Diverse Molecules

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
The second‐generation crystalline sponge method allows structurally diverse molecular guests to crystallize under standardized crystallization conditions. The key is the predominant packing type of cages and anions in crystals. ABSTRACT Crystallization is typically highly sensitive to even minor structural differences in target molecules.
Wei He, Hiroki Takezawa, Makoto Fujita
wiley   +2 more sources

Discovery of 7-(Pyridin-3-yl)thieno[3,2-<i>b</i>]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5. [PDF]

ACS Chem Neurosci
Henderson SH, Ringuette AE, Whomble DL, Capstick RA, Richardson AE, Maurer MA, Billard NB, Lei X, Wilkinson JC, Kethanapalli SH, Cho HP, Rodriguez AL, Niswender CM, Peng W, Rook JM, Chang S, Blobaum AL, Boutaud O, Felts AS, Conn PJ, Lindsley CW, Temple KJ.   +21 more
europepmc   +1 more source

Operando Investigation of Mechanochemically Synthesized Ni‐Based Metal–Organic Frameworks for Electrocatalytic Alcohol Oxidation

ChemSusChem, Volume 19, Issue 8, 28 April 2026.
A nickel‐based metal–organic framework (Ni‐MOF) with mixed N‐ and O‐donor linkers was synthesized via both mechanochemical and solvothermal routes and evaluated as an electrocatalyst for alcohol oxidation reactions (AORs). Despite having identical crystal and electronic structures, the mechanochemically synthesized Ni‐MOF (termed as MC‐MOF) exhibited ...
Arkendu Roy, Xavier Vaneberck, Celia Ganado Rodriguez, Semen Butyrin, Dominik Al‐Sabbagh, Chayanika Das, Klas Meyer, Ines Feldmann, Jörg Radnik, Ana Guilherme Buzanich, Franziska Emmerling, Biswajit Bhattacharya   +11 more
wiley   +1 more source

Enantioselective C(sp³)-H bond functionalization enabled by Cp ^<i>x</i> M(iii) catalysis (M = Co, Rh, Ir). [PDF]

Chem Sci
Mou SB, Luo MP, Fang F, Cao S, Wu D, Wang SG.   +5 more
europepmc   +1 more source