Results 111 to 120 of about 212,860 (340)

Directed Lithiation and Substitution of Pyridine Derivatives

open access: diamond, 2015
Gamal A. El‐Hiti   +2 more
openalex   +1 more source

Exploring the Uncharted Indolizine Chemical Space: Construction of 5‐Acylindolizines via a Domino Aldol–Vinylogous Aldol Process

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
A domino aldol condensation–intramolecular vinylogous aldol condensation process was implemented for the first time to enable access to a wide range of novel 5‐acylated indolizines with a hydrogen, an alkyl, an aryl, or an alkoxy moiety at the C7 site.
Dohui Ku, Sunhee Lee, Ikyon Kim
wiley   +1 more source

Boronate‐Type‐Controlled Regioselective Catalytic [2 + 2 + 2] Cyclotrimerization for Synthesis of Polysubstituted 2‐ and 3‐Borylated Pyridines

open access: yesChemistryEurope
Regioselective synthesis is a crucial concept in organic chemistry, enabling the selective formation of different regioisomers from the same type of starting materials.
Eva Bednářová   +7 more
doaj   +1 more source

Determination of Release Rate of Pyridine-triphenylborane (PTPB) from Copper-free Antifouling Paints

open access: bronze, 2005
Kazunobu Takahashi   +4 more
openalex   +2 more sources

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

open access: yesAdvanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou   +9 more
wiley   +1 more source

Regulation of Excitonic Behavior in Defective Acetylenic Polymers Enables Mechanism Switching in O2 Activation for Enhanced Water Decontamination

open access: yesAdvanced Science, EarlyView.
A molecular defect‐mediated charge accumulation strategy is developed to regulate the exciton behavior for selective molecular oxygen (O2)activation in poly(1,3,5‐triethynylbenzene) (PTEB). Artificial internal electric field (IEF) constructed in defective PTEB provides internal driving force to steer the directed migration of charge carriers, thereby ...
Xiaofeng Tang   +8 more
wiley   +1 more source

Antifouling All‐Polymeric Microneedle Array for Long‐Term Wearable ECG Monitoring

open access: yesAdvanced Science, EarlyView.
A biocompatible, all‐polymeric MNEs designed for long‐term ECG monitoring is developed. Coated with PEDOT:Tos and zwitterionic SBMA, the MNEs offer ultra‐low impedance and antifouling properties. After 14 days of continuous use, the MNEs accurately detected PQRST complexes, highlighting its potential for long‐term, real‐time ECG monitoring in everyday ...
Ju Hyeon Kim   +4 more
wiley   +1 more source

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