Results 51 to 60 of about 41,751 (271)

Mitochondria‐Targeting Moieties Based on N‐Tethered Pyridinium Cations

Angewandte Chemie, EarlyView.
Pyridinium cations were benchmarked as mitochondria‐targeting moieties in a panel of N‐tethered fluorescent‐, bioactive‐, and inert‐cargo conjugates. 3,5‐Diphenylpyridinium (DPPy+) is a competent triphenylphosphonium (TPP+) surrogate, combining high mitochondria‐targeting efficiency with lower intrinsic effects on mitochondrial function.
Ivan Džajić, Natalija Trunkelj, Jernej Repas, Maša Kandušer, Lara Smrdel, Stane Pajk, Lovro Žiberna, Irena Mlinarič‐Raščan, Bostjan Markelc, Tim Bozic, Masa Omerzel, Tanja Jesenko, Maja Cemazar, Katja Kološa, Bojana Žegura, Miha Virant, Matic Lozinšek, Hai M. Nguyen, Joshua A. Nasburg, Heike Wulff, Maxime Gueguinou, Valerije Vrček, Veronica Carpanese, Ildiko Szabo, Luis A. Pardo, Tihomir Tomašič, Lucija Peterlin Mašič, Andrej Emanuel Cotman   +27 more
wiley   +2 more sources

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

Temporal Interference Stimulation Enhances Neural Regeneration

Advanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressotti, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo‐Lara, Bethany Geary, Elena Faillace, Shirine Merlo‐Nikpay Aslie, Marcelina Wojewska, Maria Otero‐Jimenez, Martina Genta, Luqiao Tan, Karen Duff, Javier Alegre‐Abarrategui, Rylie Green, Nir Grossmann   +15 more
wiley   +1 more source

Data for the cytotoxicity, self-assembling properties and synthesis of 4-pyridinium-1,4-dihydropyridines

Data in Brief, 2020
In this data file the synthetic procedures for preparation of the original 4-pyridinium-1,4-dihydropyridines (4-Py-1,4-DHP) and their parent compounds – dialkyl 2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylates were described. In total, 5
Klavs Pajuste, Martins Rucins, Ilona Domracheva, Arkadij Sobolev, Nadiia Pikun, Mara Plotniece, Gunars Duburs, Karlis Pajuste, Aiva Plotniece   +8 more
doaj   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Cucurbit[8]Uril Achieved Single‐Molecule Chiral Transfer to Supramolecular Circularly Polarized Luminescence

Advanced Science, EarlyView.
A single‐molecule cascade supramolecular system comprising L/D‐FPy, CB[8], and SC4AD serves as an efficient light‐harvesting platform. It facilitates cascade energy transfer and chiral transfer to acceptor dyes. Co‐assembly with a PVA matrix produces a multicolor solid film that exhibits enhanced luminescence dissymmetry factors (glum), enabling ...
Yongxue Li, Jie Wu, Weiheng Zhang, Hengzhi Zhang, Wei‐Lei Zhou, Yu Liu   +5 more
wiley   +1 more source

Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Pyridinium containing sulfonamides have been largely investigated as carbonic anhydrase inhibitors (CAIs), showing interesting selectivity features. Nevertheless, only few structural studies are so far available on adducts that these compounds form with ...
Vincenzo Alterio, Davide Esposito, Simona Maria Monti, Claudiu T. Supuran, Giuseppina De Simone   +4 more
doaj   +1 more source

Simplexidine, a 4-Alkylpyridinium Alkaloid from the Caribbean Sponge Plakortis simplex

Molecules, 2008
Chemical analysis of the secondary metabolites of the Caribbean sponge Plakortis simplex, a source of many bioactive compounds, showed the presence of the new metabolite simplexidine (4), belonging to the extremely rare class of 4-alkyl-pyridinium ...
Orazio Taglialatela-Scafati, Fernando Scala, Adriana Romano, Ernesto Fattorusso   +3 more
doaj   +1 more source

The Atomistic Force Field for Pyridinium-Based Ionic Liquids: Reliable Transport Properties

, 2014
Reliable force field (FF) is a central issue in successful prediction of physical chemical properties via computer ...
Chaban, Vitaly V., Voroshylova, Iuliia V.   +1 more
core   +1 more source

Diquat Derivatives: Highly Active, Two-Dimensional Nonlinear Optical Chromophores with Potential Redox Switchability [PDF]

, 2010
In this article, we present a detailed study of structure−activity relationships in diquaternized 2,2′-bipyridyl (diquat) derivatives. Sixteen new chromophores have been synthesized, with variations in the amino electron donor substituents, π-conjugated ...
Abbotto A., Akdas-Kilig H., Alain V., Averseng F., Benjamin J. Coe, Bosshard Ch., Boubekeur-Lecaque L., Bruce S. Brunschwig, Brunschwig B. S., Bublitz G. U., Campo J., Cariati E., Champagne B., Cho B. R., Cifuentes M. P., Clays K., Clays K., Clays K., Clays K., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Cui Y.-Z., Dhenaut C., Di Bella S., Di Bella S., Di Bella S., Ferguson, B., Figi H., Franz E., Geis W., Gillaizeau-Gauthier I., Heesink G. J. T., Hendrickx E., Hennrich G., Hilton A., Inge Asselberghs, Isborn C. M., James A. Harris, Jang S.-R., Javier Garín, Jeong M.-Y., Jesús Orduna, John Fielden, Kaino T., Kawase K., Kawase K., Kim H. M., Kim H. S., Kim H. S., Knoch F., Koen Clays, Kuzuya M., Kuzyk M. G., Kuzyk M. G., Kwon O., Lacroix P. G., Le Bouder T., Le Floc’h V., Lee O.-K., Li H.-P., Li H.-P., Lindner E., Liu C.-G., Liu Y., Madeleine Helliwell, Malaun M., Marder S. R., Marder S. R., Marder S. R., Marder S. R., Maury O., Maury O., McDonagh A. M., McEntee J., Meshulam G., Miles R. E., Mohan Kumar R., Mori Y., Moylan C. R., Muhammad S., Nalwa H. S., Nunzi F., Olbrechts G., Olbrechts G., Ostroverkhov V., Oudar J. L., Oudar J. L., Papadopoulos M. G., Powell C. E., Rigamonti L., Ruiz B., Ruiz B., Schneider A., Schneider A., Simon P. Foxon, Sohma S., Sporer C., Tai O. Y.-H., Taniuchi T., Taniuchi T., Vance F. W., Vance F. W., Verbiest T., Weyland T., Willetts A., Wolff J. J., Wolff J. J., Woodford J. N., Wortmann R., Wortmann R., Xu X.-L., Yang M.-L., Yang Z., Yang Z., Yang Z., Yitzchaik S., Zhou Y.-F., Zrig S., Zyss J., Zyss J.   +131 more
core   +2 more sources