Results 71 to 80 of about 41,751 (271)

A Synthetic Route to Quaternary Pyridinium Salt-Functionalized Silsesquioxanes

International Journal of Polymer Science, 2012
A synthetic route to potentially biocidal silsesquioxanes functionalized by quaternary pyridinium functionalities has been developed. N-Alkylation reactions of the precursor compounds 4-(2-(trimethoxysilyl)ethyl)-pyridine (5) and 4-(2-trichloro ...
Nataliya Kostenko, Jochen Gottfriedsen, Liane Hilfert, Frank T. Edelmann   +3 more
doaj   +1 more source

In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon

Biomolecules, 2019
Casualties caused by organophosphorus pesticides are a burden for health systems in developing and poor countries. Such compounds are potent acetylcholinesterase irreversible inhibitors, and share the toxic profile with nerve agents.
Daniel A. S. Kitagawa, Samir F. de A. Cavalcante, Reuel L. de Paula, Rafael B. Rodrigues, Leandro B. Bernardo, Munique C. J. da Silva, Thiago N. da Silva, Wellington V. dos Santos, José M. Granjeiro, Joyce S. F. D. de Almeida, Marcos C. Barcellos, Ana Beatriz de A. Correa, Tanos C. C. França, Kamil Kuča, Alessandro B. C. Simas   +14 more
doaj   +1 more source

One-Pot Phosphate-Mediated Synthesis of Novel 1,3,5-Trisubstituted Pyridinium Salts: A New Family of S. aureus Inhibitors [PDF]

, 2017
Polysubstituted pyridinium salts are valuable pharmacophores found in many biologically active molecules. Their synthesis typically involves the use of multistep procedures or harsh reaction conditions.
Edwards, M, Gershater, MC, Hailes, HC, Pesnot, T, Ward, JM   +4 more
core   +1 more source

L-Aspartic acid pyridinium salts: In silico, synthesis and adjuvant vs antibiotic antibacterial evaluation

Results in Chemistry
In the present study, a new series of chiral L-aspartic acid pyridinium salts have been designed, guided by molecular docking as antiemetics via TrySR or DNA GryB inhibitors, as well as an adjuvant to chloramphenicol via CAT-III inhibitor to continue ...
Jessica R. Gutiérrez Cano, I. Paulina Morales-Sandoval, Dino Gnecco, Alan Carrasco-Carballo, Joel L. Terán   +4 more
doaj   +1 more source

Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification. [PDF]

, 2014
Intoxication by organophosphate (OP) nerve agents and pesticides should be addressed by efficient, quickly deployable countermeasures such as antidotes reactivating acetylcholinesterase or scavenging the parent OP.
Amitai, Gabriel, Fokin, Valery V, Radić, Zoran, Sharpless, K Barry, Sit, Rakesh K, Taylor, Palmer   +5 more
core  

Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution

Angewandte Chemie International Edition, EarlyView.
Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler   +7 more
wiley   +1 more source

Novel Charge-Transfer Materials via Cocrystallization of Planar Aromatic Donors and Spherical Polyoxometalate Acceptors [PDF]

, 2000
Spherical polyoxometalates (POMs) such as M6O192- and SiM12O404- (with M = Mo or W) and planar arene donors (anthracenes and pyrenes) can be cocrystallized (despite their structural incompatibility) by attaching a cationic “anchor” onto the arene which ...
Hubig, S. M., Kochi, Jay K., Lindeman, Sergey V., Maguères, P. Le, Peya, P.   +4 more
core   +1 more source

The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates [PDF]

, 1993
Degeneration of nigrostriatal dopaminergic neurons is the primary histopathological feature of Parkinson's disease. The neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a neurological syndrome in man and non-human primates very ...
Burg, M., Horowski, R., Kalveram, K. T., Lange, Klaus W., Löschmann, P. A., Riederer, Peter, Sofic, E., Wachtel, H.   +7 more
core   +1 more source

Synthesis of Pyridinium Moiety Containing Triazolyl Purines

Molbank
Pyridinium salts of 2-piperidinyl-6-triazolylpurine derivatives were obtained by the introduction of pyridinium moieties into the propane-1,3-diol fragment at the N(9) position of purine to enhance the solubility of 2-amino-6-triazolylpurine derivatives ...
Aleksejs Burcevs, Māris Turks, Irina Novosjolova   +2 more
doaj   +1 more source

The cycloauration of pyridine-2-thiocarboxamide ligands [PDF]

, 2010
Reactions of H[AuCl₄] with N-substituted 2-pyridine thiocarboxamide ligands 2-(C₅H₄N)C(S)NHR (R= p-C₆H₄Me, CH₂Ph, Me, p-C₆H₄OMe) gave cycloaurated derivatives {(C₅H₄N)C(S)NR}AuCl₂, with the ligand bonded as the thiol tautomer through the deprotonated SH ...
Henderson, William, Kilpin, Kelly Joan, Nicholson, Brian K.   +2 more
core   +2 more sources