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Benchmarking ML in ADMET predictions: the practical impact of feature representations in ligand-based models. [PDF]
J CheminformKamuntavičius G +8 more
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Drug Loading and Release: Development and Characterization of a Novel Therapeutic Agent-Nanographene Conjugate. [PDF]
J Phys Chem BHu K +8 more
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Pyridones as Potential Antitumor Agents II: 4-Pyridones and Bioisosteres of 3-Acetoxy-2-pyridone
Journal of Pharmaceutical Sciences, 1980Pyridone structural requirements for activity against murine P-388 leukemia have been extended to isosteric analogs of 3-hydroxy-4-pyridone, a compound previously found to have activity. An amino group can be substituted for the 3-hydroxyl function with retention of activity.
D R, Hwang, G R, Proctor, J S, Driscoll
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Journal of the Chemical Society, Chemical Communications, 1985
Lithiation of 1-methyl-4-pyridone with n-butyl-lithium at -78 °C proceeds smoothly at the C-2 position and 2-substituted-4-pyridones (1c–j) are obtained by subsequent reaction with electorphiles; lithiation of 1-methyl-2-pyridone takes place predominantly at the N-methyl, the lithio-derivative reacting rapidly, even at -78 °C with starting pyridone to ...
Premji Patel, John A. Joule
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Lithiation of 1-methyl-4-pyridone with n-butyl-lithium at -78 °C proceeds smoothly at the C-2 position and 2-substituted-4-pyridones (1c–j) are obtained by subsequent reaction with electorphiles; lithiation of 1-methyl-2-pyridone takes place predominantly at the N-methyl, the lithio-derivative reacting rapidly, even at -78 °C with starting pyridone to ...
Premji Patel, John A. Joule
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ChemInform Abstract: PHOTOISOMERIZATION OF 4‐PYRIDONES TO 2‐PYRIDONES
Chemischer Informationsdienst, 1974AbstractBestrahlung (Hg‐Mitteldrucklampe) der 4‐Pyridone (I) liefert die isomeren 2‐Pyridone (II) als Hauptprodukte, während die 4‐Pyridone (III) unter gleichen Bedingungen unverändert bleiben.
NOBUYUKI ISHIBE, JUN MASUI
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Tetrachlorobis(2-pyridone)-bis(μ2-2-pyridone)-dicopper
Acta Crystallographica Section C Crystal Structure Communications, 1993In this structure two Cu II centres 3.4448 (11) A apart are bridged asymmetrically by two 2-pyridone ligands and each is further coordinated by three terminal ligands (two chlorides and one 2-pyridone). Each molecule has an approximate, non-crystallographic centre of symmetry.
A. J. Blake, R. E. P. Winpenny
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Ambident Reactivities of Pyridone Anions
Journal of the American Chemical Society, 2010The kinetics of the reactions of the ambident 2- and 4-pyridone anions with benzhydrylium ions (diarylcarbenium ions) and structurally related Michael acceptors have been studied in DMSO, CH(3)CN, and water. No significant changes of the rate constants were found when the counterion was varied (Li(+), K(+), NBu(4)(+)) or the solvent was changed from ...
Martin, Breugst, Herbert, Mayr
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Photoisomerization of 4-pyridones to 2-pyridones
Journal of the American Chemical Society, 1974Nobuyuki Ishibe, Jun Masui
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2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease
Chemico-Biological Interactions, 2021Ian Pottie, Meghan K Cash
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