Results 121 to 130 of about 7,227 (222)

2-Pyridones from Cyanoacetamides and Enecarbonyl Compounds:  Application to the Synthesis of Nothapodytine B

, 2016
The condensation of an enone or enal with cyanoacetamide derivatives and t-BuOK furnishes either 3-cyano-2-pyridones or 3-unsubstituted-2-pyridones, depending on whether the reaction is carried out in the presence or in the absence of O2.
Kesavaram Narkunan (3028518), Denis Bouchu (2184105), Marco A. Ciufolini (117202), Sébastien Penlou (3032496), Laurence Rousset (3032502), Lionel Carles (3032499)   +5 more
core   +1 more source

Reaction of acyclic enaminones with methoxymethylene meldrum's acid: synthetic and structural implications

Journal of the Brazilian Chemical Society, 2003
The reaction of acyclic enaminones with methoxymethylene Meldrum's acid afforded N-adduct and/or C-adduct of enaminones in moderate to good yields. The regiochemistry of this reaction depends on the N-amino substituent of the enaminone. The C-adduct is a
Cunha Silvio, Silva Viviane C. da, Napolitano Hamilton B., Lariucci Carlito, Vencato Ivo   +4 more
doaj  

Competitive cyclization of ethyl trifluoroacetoacetate and methyl ketones with 1,3-diamino-2-propanol into hydrogenated oxazolo- and pyrimido-condensed pyridones. [PDF]

Beilstein J Org Chem
Kushch SO, Goryaeva MV, Burgart YV, Ezhikova MA, Kodess MI, Slepukhin PA, Volobueva AS, Zarubaev VV, Saloutin VI.   +8 more
europepmc   +1 more source

Site-Selective C–H Arylation of 2‑Pyridones via Pd/NBE Cooperative Catalysis

The 4-aryl-2-pyridone scaffold is considered to be a privileged pharmacophore. Diversity-oriented synthesis of its derivatives is a pressing demand within the field of medicinal chemistry.
Jinxiang Ye (5678825), Qinglin Li (1841404), Zibin Jiang (2255836), Chenggui Wu (1537912), Fengya He (11492692), Ziyi Sun (213357), Dan Yang (65758), Hui Miao (143177), Chenyue Li (6792269), Hujie Xiong (18461141)   +9 more
core   +1 more source

Formal [1 + 2 + 3] Annulation of Anilines and CF₃‑Containing Ynones via 6π-Electrocyclization. [PDF]

Precis Chem
Feng L, Ni SF, Lai Y, Zhang X, Lu ZX, Xiong HY, Zhang G, Wang T.   +7 more
europepmc   +1 more source

Comparative Hydrophobicity, Solubility, and Metabolic Stability of 4(1<i>H</i>)-Pyridones, 4(1<i>H</i>)-Quinolones, and 9(10<i>H</i>)-Acridones. [PDF]

ACS Med Chem Lett
Ren R, Zhong L, Noack C, Kaushik D, Leas DA, Wang X, Dong Y, Charman SA, Vennerstrom JL.   +8 more
europepmc   +1 more source

Synthesis of 3-cyano-2-pyridones from malononitrile : an honors thesis (HONRS 499)

, 2009
Substituted pyridones have multiple known uses in medicinal chemistry including topoisomerase inhibition in anticancer medicines. Cerpegin, a naturally occurring 2-pyridone, functions as an analgesic, anti-ulcer, tranquilizer, and anti-inflammatory.
Kite, Camille M., Huehls, Christopher B.
core  

Multicomponent synthesis of pyrano-pyrazolo-pyridones by a bimetallic cobalt-cadmium magnetic catalyst. [PDF]

Sci Rep
Kamali M, Mobaraki A, Shirpak Z.
europepmc   +1 more source

A Case of Immunotherapy Response to BRAF^V600E-Mutant Lung Adenocarcinoma With Initial Resistance to Dabrafenib and Trametinib Combination Therapy. [PDF]

Cancer Rep (Hoboken)
Okayama Y, Tokito T, Shiraishi S, Takaki R, Tsuneyoshi S, Yamada H, Nishiyama M, Sueyasu Y, Hoshino T.   +8 more
europepmc   +1 more source

Rhodium-Catalyzed Enantioselective Conjugate Addition of Sodium Tetraarylborates to 2,3-Dihydro-4-pyridones and 4-Quinolones by Using (R,R)-1,2-Bis(tert-butylsulfinyl)benzene as a Ligand

, 2011
(R,R)-1,2-Bis(tert-butylsulfinyl)benzene as an efficient and simple ligand can be applied in the rhodium-catalyzed asymmetric 1,4-addition of sodium tetraarylborate reagents to N-substituted 2,3-dihydro-4-pyridones and 4-quinolones.
Zhang, Xiangyang, Cun, Linfeng, Chen, Jun, Han, Fuzhong, Liao, Jian, Liao, J (reprint author), Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China.   +5 more
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