Results 161 to 170 of about 7,255 (221)

Efficacy and Safety of Adjunctive Perampanel in Young Children (7-46 Months) With Drug-Resistant Epilepsy: A Real-World Study. [PDF]

CNS Neurosci Ther
Zeng Q, Xia X, Zheng H, Yang L, Jiang L, Hu Y.   +5 more
europepmc   +1 more source

Dolutegravir concentrations in children receiving 3-month weekly isoniazid and rifapentine (3HP) for tuberculosis prevention. [PDF]

Microbiol Spectr
Madzime RJ, van der Laan L, du Toit S, Barnabas S, Courtney I, Brown NE, Savic R, Solans BP, Dixon MG, Tsirizani L, Denti P, Boyd R, Hesseling AC, TBTC Study 35 team.   +13 more
europepmc   +1 more source

Efficacy of combination chelation with deferasirox and deferiprone in children with beta-thalassemia major: an audit from a unit in the developing world. [PDF]

Clin Exp Med
James V, Prakash A.
europepmc   +1 more source

Two cases of possible transmitted HIV drug resistance to all currently available integrase inhibitors, the Netherlands, 2025. [PDF]

Euro Surveill
van Kampen J, Voermans J, Soochit W, Mesplède T, van de Laar T, van der Reijden W, Burger D, Shalev N, van Sighem A, Bezemer D, Jurriaans S, van der Vaart T, de Jong H, van der Valk M.   +13 more
europepmc   +1 more source

Synthesis and regioselective functionalization of a trihalogenated pyridone

, 2015
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Pyridones as Potential Antitumor Agents II: 4-Pyridones and Bioisosteres of 3-Acetoxy-2-pyridone

Journal of Pharmaceutical Sciences, 1980
Pyridone structural requirements for activity against murine P-388 leukemia have been extended to isosteric analogs of 3-hydroxy-4-pyridone, a compound previously found to have activity. An amino group can be substituted for the 3-hydroxyl function with retention of activity.
D R, Hwang, G R, Proctor, J S, Driscoll
openaire   +2 more sources

ChemInform Abstract: PHOTOISOMERIZATION OF 4‐PYRIDONES TO 2‐PYRIDONES

Chemischer Informationsdienst, 1974
AbstractBestrahlung (Hg‐Mitteldrucklampe) der 4‐Pyridone (I) liefert die isomeren 2‐Pyridone (II) als Hauptprodukte, während die 4‐Pyridone (III) unter gleichen Bedingungen unverändert bleiben.
NOBUYUKI ISHIBE, JUN MASUI
openaire   +1 more source

Lithiation of pyridones

Journal of the Chemical Society, Chemical Communications, 1985
Lithiation of 1-methyl-4-pyridone with n-butyl-lithium at -78 °C proceeds smoothly at the C-2 position and 2-substituted-4-pyridones (1c–j) are obtained by subsequent reaction with electorphiles; lithiation of 1-methyl-2-pyridone takes place predominantly at the N-methyl, the lithio-derivative reacting rapidly, even at -78 °C with starting pyridone to ...
Premji Patel, John A. Joule
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Pyridones as Potential Antitumor Agents

Journal of Pharmaceutical Sciences, 1979
Based on the finding that 3-acetoxy-2-pyridone had reproducible activity against murine P-388 lymphocytic leukemia, derivatives in this series were synthesized and evaluated to determine structural parameters important for activity. Of the 32 compounds tested, 10 were active.
D R, Hwang, J S, Driscoll
openaire   +2 more sources

Ambident Reactivities of Pyridone Anions

Journal of the American Chemical Society, 2010
The kinetics of the reactions of the ambident 2- and 4-pyridone anions with benzhydrylium ions (diarylcarbenium ions) and structurally related Michael acceptors have been studied in DMSO, CH(3)CN, and water. No significant changes of the rate constants were found when the counterion was varied (Li(+), K(+), NBu(4)(+)) or the solvent was changed from ...
Martin, Breugst, Herbert, Mayr
openaire   +2 more sources