Results 171 to 180 of about 9,290 (210)
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Tetrachlorobis(2-pyridone)-bis(μ2-2-pyridone)-dicopper
Acta Crystallographica Section C Crystal Structure Communications, 1993In this structure two Cu II centres 3.4448 (11) A apart are bridged asymmetrically by two 2-pyridone ligands and each is further coordinated by three terminal ligands (two chlorides and one 2-pyridone). Each molecule has an approximate, non-crystallographic centre of symmetry.
A. J. Blake, R. E. P. Winpenny
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Pyridones as Potential Antitumor Agents II: 4-Pyridones and Bioisosteres of 3-Acetoxy-2-pyridone
Journal of Pharmaceutical Sciences, 1980Pyridone structural requirements for activity against murine P-388 leukemia have been extended to isosteric analogs of 3-hydroxy-4-pyridone, a compound previously found to have activity. An amino group can be substituted for the 3-hydroxyl function with retention of activity.
D R, Hwang, G R, Proctor, J S, Driscoll
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ChemInform Abstract: PHOTOISOMERIZATION OF 4‐PYRIDONES TO 2‐PYRIDONES
Chemischer Informationsdienst, 1974AbstractBestrahlung (Hg‐Mitteldrucklampe) der 4‐Pyridone (I) liefert die isomeren 2‐Pyridone (II) als Hauptprodukte, während die 4‐Pyridone (III) unter gleichen Bedingungen unverändert bleiben.
NOBUYUKI ISHIBE, JUN MASUI
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Journal of the Chemical Society, Chemical Communications, 1985
Lithiation of 1-methyl-4-pyridone with n-butyl-lithium at -78 °C proceeds smoothly at the C-2 position and 2-substituted-4-pyridones (1c–j) are obtained by subsequent reaction with electorphiles; lithiation of 1-methyl-2-pyridone takes place predominantly at the N-methyl, the lithio-derivative reacting rapidly, even at -78 °C with starting pyridone to ...
Premji Patel, John A. Joule
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Lithiation of 1-methyl-4-pyridone with n-butyl-lithium at -78 °C proceeds smoothly at the C-2 position and 2-substituted-4-pyridones (1c–j) are obtained by subsequent reaction with electorphiles; lithiation of 1-methyl-2-pyridone takes place predominantly at the N-methyl, the lithio-derivative reacting rapidly, even at -78 °C with starting pyridone to ...
Premji Patel, John A. Joule
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Journal of the Chemical Society B: Physical Organic, 1968
The reaction between N-alkyl-2-pyridones and tetracyanoethylene produces 2 : 1 salts of the pyridone with pentacyanopropene. Metathetical exchange of these salts with 4H-quinolizin-4-one leads to mono- and bis-quinolizone salts. Similar salts are formed with hydroquinone in place of pentacyanopropene.
B. S. Thyagarajan +2 more
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The reaction between N-alkyl-2-pyridones and tetracyanoethylene produces 2 : 1 salts of the pyridone with pentacyanopropene. Metathetical exchange of these salts with 4H-quinolizin-4-one leads to mono- and bis-quinolizone salts. Similar salts are formed with hydroquinone in place of pentacyanopropene.
B. S. Thyagarajan +2 more
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Pyridones as Potential Antitumor Agents
Journal of Pharmaceutical Sciences, 1979Based on the finding that 3-acetoxy-2-pyridone had reproducible activity against murine P-388 lymphocytic leukemia, derivatives in this series were synthesized and evaluated to determine structural parameters important for activity. Of the 32 compounds tested, 10 were active.
D R, Hwang, J S, Driscoll
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Ambident Reactivities of Pyridone Anions
Journal of the American Chemical Society, 2010The kinetics of the reactions of the ambident 2- and 4-pyridone anions with benzhydrylium ions (diarylcarbenium ions) and structurally related Michael acceptors have been studied in DMSO, CH(3)CN, and water. No significant changes of the rate constants were found when the counterion was varied (Li(+), K(+), NBu(4)(+)) or the solvent was changed from ...
Martin, Breugst, Herbert, Mayr
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Chemical Physics Letters, 2000
Abstract DFT/B3-LYP(6-31++G**) calculations are used to provide information on closed N – H ⋯ O H -bonded complexes, containing two hydrogen bonds. The studied model systems with two H-bonds are the 2-pyridone dimer, 2-pyridone–H2O and 2-pyridone–CH3OH.
A. Dkhissi +4 more
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Abstract DFT/B3-LYP(6-31++G**) calculations are used to provide information on closed N – H ⋯ O H -bonded complexes, containing two hydrogen bonds. The studied model systems with two H-bonds are the 2-pyridone dimer, 2-pyridone–H2O and 2-pyridone–CH3OH.
A. Dkhissi +4 more
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Pyridone photoelectrocyclizations to pyridophenanthrenes
Tetrahedron, 2017Abstract This article describes the synthesis of pyridophenanthrenes from the stereoselective electrocyclization and [1,5]-hydride shift sequences of biphenyl pyridones. The regioselectivity of the reaction of meta-substituted biphenyl substrates depended on the electronic environment of the substituents.
Xuchen Zhao, Jon D. Rainier
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Synthetic Entries to Substituted Bicyclic Pyridones
Organic Letters, 2007The synthesis of 6,6- and 5,6-bicyclic pyridone scaffolds has been completed using (i) an intramolecular Mitsunobu reaction and/or (ii) hydrolysis of a bicyclic pyridinium salt intermediate. Regioselective functionalization of the pyridone ring has been achieved via either direct lithiation or use of the "halogen dance" reaction.
Cheng, DC +4 more
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