Current Advances on Structure-Function Relationships of Pyridoxal 5′-Phosphate-Dependent Enzymes
Frontiers in Molecular Biosciences, 2019 Pyridoxal 5′-phosphate (PLP) functions as a coenzyme in many enzymatic processes, including decarboxylation, deamination, transamination, racemization, and others.
Jing Liang +4 more
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Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase. [PDF]
PLoS ONE, 2012 Pyridoxal 5'-phosphate (PLP) is a cofactor for dozens of B(6) requiring enzymes. PLP reacts with apo-B(6) enzymes by forming an aldimine linkage with the ε-amino group of an active site lysine residue, thus yielding the catalytically active holo-B(6 ...
Mohini S Ghatge +10 more
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Complexation of Gold(III) with Pyridoxal 5′-Phosphate-Derived Hydrazones in Aqueous Solution [PDF]
Molecules, 2022 Today, complexes of gold(I) and gold(III) are recognized as promising drugs for the treatment of bacterial infectious diseases and oncological diseases, respectively.
Natalia N. Kuranova +3 more
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Association of pyridoxal 5′-phosphate (PLP) with lipid profiles: a population-based cohort study [PDF]
Frontiers in NutritionObjectivesThis study aims to explore the correlation between Pyridoxal 5′-Phosphate (PLP) levels and lipid profiles in adult individuals, utilizing data from the National Health and Nutrition Examination Survey (NHANES) database.MethodsThe research ...
Ru-yang Zhang +5 more
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Biomedical aspects of pyridoxal 5'-phosphate availability.
Frontiers in Bioscience, 2012 The biologically active form of vitamin B6, pyridoxal 5'-phosphate (PLP), is a cofactor in over 160 enzyme activities involved in a number of metabolic pathways, including neurotransmitter synthesis and degradation. In humans, PLP is recycled from food and from degraded PLP-dependent enzymes in a salvage pathway requiring the action of pyridoxal kinase,
M. D. di Salvo, M. Safo, R. Contestabile
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yggS Encoding Pyridoxal 5′-Phosphate Binding Protein Is Required for Acidovorax citrulli Virulence [PDF]
Frontiers in Microbiology, 2022 Bacterial fruit blotch, caused by seed-borne pathogen Acidovorax citrulli, poses a serious threat to the production of cucurbits globally. Although the disease can cause substantial economic losses, limited information is available about the molecular ...
Yuanjie Wang +9 more
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Purine limitation prevents the exogenous pyridoxal 5′-phosphate accumulation of Salmonella enterica yggS mutants [PDF]
Microbiology SpectrumYggS belongs to the highly conserved pyridoxal 5′-phosphate (PLP) binding protein family (COG0325) that is found in all domains of life. Though no precise biochemical activity or molecular mechanism has been determined for this protein, an involvement in
Kailey S. Ezekiel, Diana M. Downs
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Native Microbiome Members of C. elegans Act Synergistically in Biosynthesis of Pyridoxal 5′-Phosphate [PDF]
Metabolites, 2022 The roles of the healthy microbiome on the host and the relationships between members of the microbiome remain to be fully characterized. Due to the complexity of the interactions between the mammalian microbiome and its host, the use of model organisms ...
Orçun Haçariz +3 more
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Chemogenomics of pyridoxal 5′-phosphate dependent enzymes
Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 Pyridoxal 5'-phosphate (PLP) dependent enzymes comprise a large family that plays key roles in amino acid metabolism and are acquiring an increasing interest as drug targets. For the identification of compounds inhibiting PLP-dependent enzymes, a chemogenomics-based approach has been adopted in this work. Chemogenomics exploits the information coded in
Ratna Singh +5 more
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Simultaneous Determination of Underivatized Vitamin B1 and B6 in Whole Blood by Reversed Phase Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry. [PDF]
PLoS ONE, 2015 Vitamin B1 (thiamine-diphosphate) and B6 (pyridoxal-5'phosphate) are micronutrients. Analysis of these micronutrients is important to diagnose potential deficiency which often occurs in elderly people due to malnutrition, in severe alcoholism and in ...
Johan Puts +3 more
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