A New Synthesis of Pyridoxal-5-phosphate [PDF]
Bulletin of the Chemical Society of Japan, 1968 Abstract By the hydrolysis of pyridoxal-5-phosphate Schiff bases, pyridoxal-5-phosphate was prepared in a crystalline form without any further purification. Pyridoxal-5-phosphate Schiff bases were prepared in good yields by the phosphorylation of pyridoxal Scruff bases and were easily purified by alkali-acid reprecipitation.
M, Iwanami, T, Numata, M, Murakami
openaire +2 more sources
Investigation of Structural Dynamics of Enzymes and Protonation States of Substrates Using Computational Tools. [PDF]
, 2016 This review discusses the use of molecular modeling tools, together with existing experimental findings, to provide a complete atomic-level description of enzyme dynamics and function.
Chang, Chia-En A +3 more
core +2 more sources
ACS Sustainable Chemistry and Engineering, 2018 We expanded the application of self-sufficient heterogeneous biocatalysts containing coimmobilized ω-transaminases and pyridoxal 5′-phosphate (PLP) to efficiently operate packed-bed reactors in continuous flow.
A. I. Benítez-Mateos +4 more
semanticscholar +1 more source
Family case of aromatic L-amino acid decarboxylase deficiency
Нервно-мышечные болезни, 2022 Aromatic L‑amino acid decarboxylase (AADC) deficiency is rare autosomal recessive neurometabolic disorder. It caused by generalized combined deficiency of serotonin, dopamine, norepinephrine and adrenaline.
O. B. Kondakova +9 more
doaj +1 more source
Applied and Environmental Microbiology, 2019 Recent studies showed that deletion or mutation of members of the YggS protein family causes pleiotropic effects in many organisms. Little is known about the causes, mechanisms, and consequences of these diverse phenotypes.
Tomokazu Ito +6 more
semanticscholar +1 more source
The Streptomyces coelicolor small ORF trpM stimulates growth and morphological development and exerts opposite effects on actinorhodin and calcium-dependent antibiotic production [PDF]
, 2020 In actinomycetes, antibiotic production is often associated with a morpho-physiological differentiation program that is regulated by complex molecular and metabolic networks. Many aspects of these regulatory circuits have been already elucidated and many
Alberto Vassallo +7 more
core +2 more sources
PDXK mutations cause polyneuropathy responsive to pyridoxal 5′‐phosphate supplementation
Annals of Neurology, 2019 To identify disease‐causing variants in autosomal recessive axonal polyneuropathy with optic atrophy and provide targeted replacement therapy.
V. Chelban +144 more
semanticscholar +1 more source
Identification of atropine-and P2X1 receptor antagonist-reistant, neurogenic contractions of the urinary bladder [PDF]
, 2007 Acetylcholine and ATP are excitatory cotransmitters in parasympathetic nerves. We used P2X1 receptor antagonists to further characterize the purinergic component of neurotransmission in isolated detrusor muscle of guinea pig urinary bladder.
Gallagher, Gemma +3 more
core +1 more source
Molecular dynamics simulation unveils the conformational flexibility of the interdomain linker in the bacterial transcriptional regulator GabR from Bacillus subtilis bound to pyridoxal 5'-phosphate [PDF]
, 2017 GabR from Bacillus subtilis is a transcriptional regulator belonging to the MocR subfamily of the GntR regulators. The structure of the MocR regulators is characterized by the presence of two domains: i) a N-terminal domain, about 60 residue long ...
Guidoni, Leonardo +4 more
core +4 more sources
JBMR Plus, 2019 The response to teriparatide has been described in very few cases of hypophosphatasia (HPP). In this cross‐sectional study, we report the prevalence of symptomatic bone marrow edema (BME) and fracture healing complications in a large cohort of childhood ...
Tobias Schmidt +6 more
doaj +1 more source