Results 81 to 90 of about 174,380 (258)

Serine racemases from barley, Hordeum vulgare L., and other plant species represent a distinct eukaryotic group: gene cloning and recombinant protein characterization [PDF]

, 2007
Several D-amino acids have been identified in plants. However, the biosynthetic pathway to them is unclear. In this study, we cloned and sequenced a cDNA encoding a serine racemase from barley which contained an open reading frame encoding 337 amino ...
Fujitani, Yoshiyuki, Horiuchi, Terumi, Ito, Kazutoshi, Sugimoto, Manabu   +3 more
core   +1 more source

Bottom‐up Strategies for Generating Polymer Protocells That Mimic Cellular Communication

Chemistry – A European Journal, EarlyView.
This review focuses on polymeric protocells produced using a bottom‐up approach. Polymer‐based assemblies guarantee stability and designability by adjusting the properties of the amphiphilic copolymers used. The review covers protocell architectures, production, and their intra‐ and intercellular communication mechanisms.
Gloria Saorin, Xinan Huang, Voichita Mihali, Cornelia G. Palivan   +3 more
wiley   +1 more source

Immediate-type hypersensitivity to pyridoxal 5'- phosphate: Study of in vivo and in vitro cross-reactivity and identification of the antigenic determinant

Allergology International, 2001
Background: A case in which a 45-year-old female patient with peritonitis experienced immediate-type hypersensitivity on two occasions after administration of preparations containing six different medications was referred to us for closer inspection ...
Masako Osada, Noriko Oki, Yukari Okubo, Tsunao Oh-i, Michiyuki Koga, Sadao Arai   +5 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Pyridoxine Responsiveness and PNPO Gene Mutations

Pediatric Neurology Briefs, 2014
Investigators at University Hospital, Zurich, Switzerland, and multiple centers in Europe and Canada, sequenced the pyridoxal 5-phosphate oxidase (PNPO) gene in 31 patients with pyridoxine-responsive seizures but normal biomarkers for antiquitin ...
J Gordon Millichap, John J Millichap
doaj   +1 more source

Pyridoxal‐5′‐phosphate: A cost‐effective treatment candidate for hypertensive patients?

Journal of Internal Medicine
AbstractObjectivesBecause angiotensin (Ang) II is an essential vasoconstrictive peptide, we analyzed the impact of its post‐translational modification to pyruvamide–Ang II (Ang P) by pyridoxal‐5′‐phosphate (PLP) on blood pressure. PLP is a less expensive vitamin B6 derivative and, therefore, could be a cost‐effective drug against hypertension ...
Michaela Lellig, Mariano Rodríguez, Rodrigo López‐Baltanás, Juliane Hermann, Julia Wollenhaupt, Heidi Noels, Walter Zidek, Martin Tepel, Felix Mahfoud, Joachim Jankowski, Juan R. Muñoz‐Castañeda, Vera Jankowski   +11 more
openaire   +3 more sources

Epilepsy syndromes classification

Epilepsia Open, EarlyView.
Abstract Epilepsy syndromes are distinct electroclinical entities which have been recently defined by the International League Against Epilepsy Nosology and Definitions Task Force. Each syndrome is associated with “a characteristic cluster of clinical and EEG features, often supported by specific etiologic findings”.
Elaine C. Wirrell, Nicola Specchio, Rima Nabbout, Phillip L. Pearl, Kate Riney   +4 more
wiley   +1 more source

Chemoenzymatic synthesis of 1-deaza-pyridoxal 5′-phosphate [PDF]

Bioorganic & Medicinal Chemistry Letters, 2010
The first synthesis of 1-deaza-pyridoxal 5'-phosphate (2-formyl-3-hydroxy-4-methylbenzyl phosphate) is described. The chemoenzymatic approach described here is a reliable route to this important isosteric pyridoxal phosphate analogue. This work enables elucidation of the role of the pyridine nitrogen in pyridoxal 5'-phosphate dependent enzymes.
Wait R, Griswold, Michael D, Toney
openaire   +2 more sources

Manual for starch gel electrophoresis: A method for the detection of genetic variation [PDF]

, 1987
The procedure to conduct horizontal starch gel electrophoresis on enzymes is described in detail. Areas covered are (I) collection and storage of specimens, (2) preparation of tissues, (3) preparation of a starch gel, (4) application of enzyme extracts ...
Aebersold, Paul B., Milner, George B., Teel, David J., Utter, Fred M., Winans, Gary A.   +4 more
core  

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source