Results 1 to 10 of about 54,693 (289)

Facile immobilization of pyridoxal 5′-phosphate using p-diazobenzoyl-derivatized Sepharose 4B [PDF]

Results in Chemistry, 2023
Pyridoxal 5′-phosphate (PLP) is a ubiquitous and versatile cofactor utilized by numerous enzymes involved in amino acid biosynthetic pathways. Immobilized PLP is a valuable tool to isolate unknown PLP-dependent enzymes in nature or to perform in vitro ...
Kun-Hwa Lee, Mark D. Distefano, Burckhard Seelig   +2 more
doaj   +3 more sources

Pyridoxal 5'-Phosphate Biosynthesis by Pyridox-(am)-ine 5'-Phosphate Oxidase: Species-Specific Features. [PDF]

Int J Mol Sci
Enzymes reliant on pyridoxal 5'-phosphate (PLP), the metabolically active form of vitamin B6, hold significant importance in both biology and medicine. They facilitate various biochemical reactions, particularly in amino acid and neurotransmitter metabolisms. Vitamin B6 is absorbed by organisms in its non-phosphorylated form and phosphorylated
Rivero M, Novo N, Medina M.
europepmc   +7 more sources

Association between serum pyridoxal 5′-phosphate levels and chronic obstructive pulmonary disease: findings based on NHANES 2005–2010 [PDF]

Frontiers in Nutrition
ObjectiveVitamin B6 is involved in regulating a variety of biological reactions in cell metabolism, and possesses antioxidant and anti-inflammatory biological functions.
Yanbin Liu, Jun Yan
doaj   +4 more sources

Pyridoxal-5'-Phosphate-Dependent Catalytic Antibodies [PDF]

Applied Biochemistry and Biotechnology, 2000
Cofactors--i.e., metal ions and coenzymes--extend the catalytic scope of enzymes and might have been among the first biological catalysts. They may be expected to efficiently extend the catalytic potential of antibodies. Monoclonal antibodies (MAbs) against Nalpha-phosphopyridoxyl-L-lysine were screened for 1) binding of 5'-phosphopyridoxyl amino acids,
Gramatikova, Svetlana I, Christen, Philipp   +1 more
core   +7 more sources

Enzyme-independent catabolism of cysteine with pyridoxal-5′-phosphate [PDF]

Scientific Reports, 2023
Pyridoxal-5′-phosphate (PLP) is a versatile cofactor that assists in different types of enzymatic reactions. PLP has also been reported to react with substrates and catalyze some of these reactions independent of enzymes.
Prajakatta Mulay, Cindy Chen, Vijay Krishna   +2 more
doaj   +2 more sources

SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation [PDF]

Nature Communications
Many essential proteins require pyridoxal 5’-phosphate, the active form of vitamin B6, as a cofactor for their activity. These include enzymes important for amino acid metabolism, one-carbon metabolism, polyamine synthesis, erythropoiesis, and ...
Izabella A. Pena, Jeffrey S. Shi, Sarah M. Chang, Jason Yang, Samuel Block, Charles H. Adelmann, Heather R. Keys, Preston Ge, Shveta Bathla, Isabella H. Witham, Grzegorz Sienski, Angus C. Nairn, David M. Sabatini, Caroline A. Lewis, Nora Kory, Matthew G. Vander Heiden, Myriam Heiman   +16 more
doaj   +2 more sources

Pyridoxal 5′-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring [PDF]

Environmental Science and Ecotechnology, 2023
Pyridaben (PY) is a widely used organochlorine acaricide, which can be detected in the peripheral blood of pregnant women. Available evidence suggests that PY has reproductive toxicity.
Xingwang Ding, Ya Wen, Xuan Ma, Yuepei Zhang, Yuting Cheng, Zhaofeng Liu, Weiyue Hu, Yankai Xia   +7 more
doaj   +2 more sources

Case report: Hepatocellular carcinoma in a patient with Pyridoxamine 5-phosphate oxidase (PNPO) deficiency undergoing pyridoxal 5-phosphate (PLP) treatment [PDF]

Molecular Genetics and Metabolism Reports
Pyridoxamine 5-phosphate oxidase (PNPO) deficiency is an autosomal recessive inborn error of metabolism that typically manifests as seizures resistant to conventional anticonvulsants, often presenting in the neonatal period to early infancy.
Jesse Zhen Cheng Lee, Chit Kwong Chow, Cheuk-Wing Fung, Stephen Tak Yau Lui, Suet-Na Sheila Wong   +4 more
doaj   +2 more sources

Supramolecular Tandem Assay for Pyridoxal‐5′‐phosphate by the Reporter Pair of Guanidinocalix[5]Arene and Fluorescein

ChemistryOpen, 2019
Guanidinocalix[5]arene and fluorescein reporter pair has been chosen to set up a supramolecular tandem assay principle based on the differential recognition of pyridoxal‐5′‐phosphate (the substrate of alkaline phosphatase, ALP), pyridoxal (the product of
Yu‐Xin Yue, Yong Kong, Fan Yang, Zhe Zheng, Xin‐Yue Hu, Dong‐Sheng Guo   +5 more
doaj   +2 more sources

Complexation of Gold(III) with Pyridoxal 5′-Phosphate-Derived Hydrazones in Aqueous Solution [PDF]

Molecules, 2022
Today, complexes of gold(I) and gold(III) are recognized as promising drugs for the treatment of bacterial infectious diseases and oncological diseases, respectively.
Natalia N. Kuranova, Daniil N. Yarullin, Maksim N. Zavalishin, George A. Gamov   +3 more
doaj   +2 more sources