Results 51 to 60 of about 150,330 (220)
Cloning and Characterization of Pyridoxal Kinase from Geobacillus sp. H6a
Pyridoxal kinase encoded by pdxK gene, is the important key enzyme in the salvage pathway of vitamin B6 biosynthesis. The enzyme catalyzes the phosphorylation of the 5′ alcohol groups of free form vitamin B6 into their 5′-phosphate forms that requires ...
Jumnong Pasri+2 more
doaj +1 more source
Vitamin B6‐dependent epilepsies are a heterogeneous group of disorders characterized by decreased availability of the active cofactor pyridoxal‐5′‐phosphate (PLP).
Oliver Heath+5 more
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Although the routes of de novo pyridoxal 5′-phosphate (PLP) biosynthesis have been well described, studies of the engineering of an intracellular PLP supply are limited and the effects of cellular PLP levels on PLP-dependent enzyme-based whole-cell ...
Weichao Ma+6 more
semanticscholar +1 more source
Thorough study of composition and fluorescence properties of a commercial reagent of active equine NAD-dependent alcohol dehydrogenase expressed and purified from E. coli has been carried out. Several experimental methods: spectral- and time-resolved two-
Ioanna A. Gorbunova+6 more
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Pyridoxal 5 phosphate for neuroleptic-induced tardive dyskinesia.
BACKGROUND Tardive dyskinesia is a chronic and disabling abnormal movement disorder affecting the muscles of the face, neck, tongue and the limbs. It is a common side effect of long-term antipsychotic medication use in individuals with schizophrenia and ...
A. Adelufosi+2 more
semanticscholar +1 more source
Pyridoxal‐5′‐phosphate as a probe for rotational diffusion [PDF]
Its usefulness in measuring the slow rotation of proteins and micelles was demonstrated.
Timothy J. Cornish, John W. Ledbetter
openaire +2 more sources
Glutamate in Pyridoxine-Dependent Epilepsy
Cerebrospinal fluid levels of glutamate, g-aminobutyric acid, and pyridoxal-5-phosphate examined in a patient with pyridoxine dependency while on and off vitamin B6 treatment are reported from Universitat Munchen, and Universitats-Nervenklinik, Wurzburg,
J Gordon Millichap
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BACKGROUND Vitamin B-6 interconversion enzymes are important for supplying pyridoxal 5'-phosphate (PLP), the co-enzyme form, to tissues. Variants in the genes for these enzymes [tissue nonspecific alkaline phosphatase (ALPL), pyridoxamine 5'-phosphate ...
Tonia C. Carter+14 more
semanticscholar +1 more source
GABA Synthesis and Pyridoxine Seizures
A reduction in pyridoxal-5-phosphate (PLP) dependent enzyme, glutamic acid decarboxylase (GAD),which synthesizes GABA, is reported in a 3 month-old infant with seizures responsive to pyridoxine treated at University of California, Davis.
J Gordon Millichap
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Pyridoxine Responsiveness and PNPO Gene Mutations
Investigators at University Hospital, Zurich, Switzerland, and multiple centers in Europe and Canada, sequenced the pyridoxal 5-phosphate oxidase (PNPO) gene in 31 patients with pyridoxine-responsive seizures but normal biomarkers for antiquitin ...
J Gordon Millichap, John J Millichap
doaj +1 more source