Results 61 to 70 of about 150,330 (220)
Peroxidized phospholipid-mediated cytotoxity is involved in the pathophysiology of a number of diseases [i.e., the abnormal increase of phosphatidylcholine hydroperoxide (PCOOH) found in the plasma of type 2 diabetic patients]. The PCOOH accumulation may
Ohki Higuchi+5 more
doaj
Background Tissue-nonspecific alkaline phosphatase (TNSALP) encoded by the ALPL gene is of particular importance for bone mineralization. Mutation in the ALPL gene can lead to persistent low ALP activity resulting in the rare disease Hypophosphatasia ...
Tobias Schmidt+4 more
doaj +1 more source
Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation.
A variety of inflammatory disease conditions have been found to be associated with low levels of plasma pyridoxal 5'-phosphate (PLP), the active form of vitamin B6 , without any indication of a lower dietary intake of vitamin B6 , excessive catabolism of
L. Paul, P. Ueland, J. Selhub
semanticscholar +1 more source
Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists
P2X receptors are extracellular ATP-gated ion channels that form homo- or heterotrimers and consist of seven subtypes. They are expressed in various tissues, including neuronal and nonneuronal cells, and play critical roles in physiological processes ...
Danqi Sheng+7 more
doaj +1 more source
Background Cerebrospinal fluid (CSF) metabolomic investigations are a powerful tool for studying neurometabolic diseases. We aimed to assess the effect of CSF contamination with blood on the concentrations of selected biomarkers. Methods CSF samples were
Marta Batllori+10 more
doaj +1 more source
Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives
O-acetylserine sulfhydrylase (OASS) is the pyridoxal 5′-phosphate dependent enzyme that catalyses the formation of L-cysteine in bacteria and plants. Its inactivation is pursued as a strategy for the identification of novel antibiotics that, targeting ...
Nina Franko+5 more
doaj +1 more source
Late-onset drug-resistant epilepsy in pyridoxamine 5′-phosphate oxidase deficiency: a case report
Background Pyridoxamine 5′-phosphate oxidase deficiency is a rare inborn error of vitamin B6 metabolism that presents with drug-resistant epileptic seizures.
Erfan Naghavi+8 more
doaj +1 more source
The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT) is required for de novo sphingolipid biosynthesis. A previous study revealed a novel and unexpected interaction between the hydroxyl group of the l-serine substrate and ...
A. E. Beattie+5 more
semanticscholar +1 more source
Biomedical aspects of pyridoxal 5'-phosphate availability.
The biologically active form of vitamin B6, pyridoxal 5'-phosphate (PLP), is a cofactor in over 160 enzyme activities involved in a number of metabolic pathways, including neurotransmitter synthesis and degradation.
M. D. di Salvo, M. Safo, R. Contestabile
semanticscholar +1 more source
Background The vitamins are important cofactors in various enzymatic-reactions. In past, many inhibitors have been designed against vitamin binding pockets in order to inhibit vitamin-protein interactions.
Panwar Bharat+2 more
doaj +1 more source