Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists
eLifeP2X receptors are extracellular ATP-gated ion channels that form homo- or heterotrimers and consist of seven subtypes. They are expressed in various tissues, including neuronal and nonneuronal cells, and play critical roles in physiological processes ...
Danqi Sheng +7 more
doaj +1 more source
Purification and properties of diaminopimelate decarboxylase of Micrococcus glutamicus [PDF]
, 1981 Diaminopimelate decarboxylase (EC 4.1.1.20) of Micrococcus glutamicus ATCC 13059 was purified to homogeneity. The enzyme had an apparent molecular weight of 191,000 as determined by gel filtration on Sephadex G-200. At protein concentrations of 20 and 10
Lakshman, Meena +2 more
core +1 more source
Impact of polysaccharides on advancing plant‐based meat alternatives
Food Biomacromolecules, EarlyView.An outline of plant‐based meat production by incorporating polysaccharides. Abstract Plant‐based meat products are a valued choice for vegetarians and others. Their production has been perceived as an innovation promoting animal welfare and sustainability.
Prashant Dahal +2 more
wiley +1 more source
Structural and biophysical analysis of important biomedical enzymes and nano-architectures [PDF]
, 2008 Dopa decarboxylase (DDC) is an important enzyme in the catecholamine biosynthesis pathways. Catecholamines, e.g., dopamine, serotonin, etc. often are the major neuromodulators or neurotransmitters.
Chattopadhyay, Arundhati
core +1 more source
Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?
Acta Ophthalmologica, EarlyView.Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs +12 more
wiley +1 more source
Plasma Pyridoxal 5´-Phosphate Level in Children with Intractable and Controlled Epilepsy [PDF]
Objective Intractable epilepsy is a serious neurologic problem with different etiologies. Decreased levels of pyridoxal phosphate in cerebral spinal fluid of patients with intractable epilepsy due to pyridoxine dependency epilepsy are reported.
Ghofrani, Mohammad +2 more
core
Inflammation causes tissue-specific depletion of vitamin B(6) [PDF]
, 2005 Previously we observed strong and consistent associations between vitamin B(6 )status and several indicators of inflammation in patients with rheumatoid arthritis.
Chiang, En-Pei +5 more
core +3 more sources
Bioinformatics Comparison of \u3cem\u3eM. ruber\u3c/em\u3e Mrub_2507 to \u3cem\u3eE. coli\u3c/em\u3e pdxK/b1636 and \u3cem\u3eM. ruber\u3c/em\u3e Mrub_2888 to \u3cem\u3eE. coli\u3c/em\u3e pdxH/b1638 to Determine the Orthologous Nature [PDF]
, 2016 This project is part of the Meiothermus ruber genome analysis project, which uses the bioinformatics tools associated with the Guiding Education through Novel Investigation – Annotation Collaboration Toolkit (GENI-ACT) to predict gene function.
Bernardi, Adam, Scott, Dr. Lori
core +1 more source
Highly efficient generation of pulsed photon pair using a bulk Periodically Poled Potassium Titanyl Phosphate [PDF]
, 2003 In this paper, we demonstrate efficient generation of collinearly propagating, degenerate pulsed photon pairs based on a bulk Periodically Poled Potassium Titanyl Phosphate pumped by an ultrashort pulse laser. Using a single-mode fiber as a spatial mode filter, we detect about 3200 coincidence counts per second per milliwatt pump power.
arxiv +1 more source
Epilepsia, EarlyView.Abstract De novo variants in KCNQ2 cause neonatal onset developmental and epileptic encephalopathy (KCNQ2‐DEE; Online Mendelian Inheritance in Man #613720), most often by loss‐of‐function in vitro effects. In this study, we describe a neonatal onset DEE proband carrying a recurrent de novo KCNQ2 variant (c.794C>T; p.A265V) affecting the pore domain of ...
Ingride Luzio Gaspar +6 more
wiley +1 more source