Results 101 to 110 of about 55,337 (248)

Pyridoxal phosphate-dependent neonatal epileptic encephalopathy

Archives of Disease in Childhood - Fetal and Neonatal Edition, 2008
Pyridox(am)ine-5′-phosphate oxidase converts pyridoxine phosphate and pyridoxamine phosphate to pyridoxal phosphate, a cofactor in many metabolic reactions, including neurotransmitter synthesis. A family with a mutation in the pyridox(am)ine-5′-phosphate oxidase gene presenting with neonatal seizures unresponsive to pyridoxine and anticonvulsant ...
S, Bagci, J, Zschocke, G F, Hoffmann, T, Bast, J, Klepper, A, Müller, A, Heep, P, Bartmann, A R, Franz   +8 more
openaire   +4 more sources

Chemical Composition, Amino Acids, Phenolic Profiles and Bioavailability of Minerals in Livingstone Potato (Plectranthus esculentus) as Affected by Different Processing Techniques

Food Chemistry International, EarlyView.
Boiling retained the nutrients and polyphenol compounds in Plectranthus esculentus tubers better than frying or roasting. A bioavailability study showed that the phytates and oxalates in the tuber may not affect the bioavailabilities of calcium, zinc, or iron in Plectranthus esculentus tubers when eaten.
Mercy Amarachi Iroaganachi, Chinedum Ogbonnaya Eleazu, Kate Eleazu, Adanma Ironkwe, Winner Kalu   +4 more
wiley   +1 more source

Do dietary patterns in older men influence change in homocysteine through folate fortification? The Normative Aging Study [PDF]

Objective We aimed to describe the difference in B-vitamin intake and in plasma B-vitamin and homocysteine concentrations before and after folic acid fortification, in relation to dietary patterns. Design The Normative Aging Study (NAS) is a longitudinal
Groot, C.P.G.M., de, Knoops, K.T.B., Kromhout, D., Spiro, A., Staveren, W.A., van, Tucker, K.L.   +5 more
core   +2 more sources

Pyridoxal Phosphate Supplementation in Neuropediatric Disorders

Seminars in Pediatric Neurology, 2016
Pyridoxal phosphate (PLP) is the active form of vitamin B6 and a cofactor in many enzyme reactions including neurotransmitter metabolism. PLP metabolism disturbances may mostly lead to refractory seizures. In this report, we review the main pathophysiological factors related with PLP deficiency and our experience in PLP treatment in pediatric patients ...
Cortés-Saladelafont E, Molero M, Hsjd Working Group, Artuch-Iriberri R, Garcia-Cazorla A   +4 more
openaire   +3 more sources

Infused Tiger Nut and Almond Nut Crunchy Snacks Enhanced the Nutritional Value and Antioxidant Activity in High‐Fat Diet Fed Rat

Food Chemistry International, EarlyView.
Crunches were produced from formulations of almond nuts and tiger nuts (AN–TN) for the plausible management of commodity disease of obese condition. The produced AN–TN crunches showed high consumers acceptability, phenolic, and amylopectin contents. In addition, formulated percentages of AN–TN crunches when fed to high‐fat diet (HFD) fed rats led to ...
Olufunke Florence Ajeigbe, Ayokunle Olubode Ademosun, Ganiyu Oboh, Oluwatobi Emmauel Allen, Bolaji Lawrence Awe   +4 more
wiley   +1 more source

Current Insight into Human Ornithine Aminotransferase: A Review

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Human ornithine aminotransferase (hOAT) is a mitochondrial matrix pyridoxal‐5′‐phosphate enzyme (PLP) that catalyzes the reversible transfer of the δ‐amino group of L‐ornithine (L‐Orn) to α‐ketoglutarate (α‐KG) yielding glutamate‐5‐semialdehyde (GSA) and glutamate. GSA is prone to cyclize to Δ1‐pyrroline‐5‐carboxylate.
Fulvio Floriani, Carla Borri Voltattorni, Riccardo Montioli   +2 more
wiley   +1 more source

Crystal structure of the plant GABA aminotransferase AtGABA‐T from Arabidopsis thaliana

Acta Crystallographica Section F, EarlyView.
The crystal structure of A. thaliana γ‐aminobutyric acid aminotransferase (GABA‐T) reveals that plant GABA‐T belongs to the class III aminotransferase family and employs a C‐terminal arginine residue for γ‐aminobutyric acid recognition, in contrast to the N‐terminal arginine used by class II enzymes.γ‐Aminobutyric acid aminotransferase (GABA‐T) is a ...
Naofumi Okoda, Suguru Okuda, Kenta Tsutsumi, Hideaki Itoh, Ken Okamoto, Hiroshi Kawakami, Kaori Sano, Kenji Kobata, Koji Nagata   +8 more
wiley   +1 more source

Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy

Pharmaceuticals
Background/Objectives: Septic cardiomyopathy (SCM) is a severe cardiac complication of sepsis, characterized by cardiac dysfunction with limited effective treatments.
Pei-Pei Liu, Xin-Yue Yu, Qing-Qing Pan, Jia-Jun Ren, Yu-Xuan Han, Kai Zhang, Yan Wang, Yin Huang, Tao Ban   +8 more
doaj   +1 more source

Should PNPO Deficiency Be Treated In Utero? Clinical Findings From Prenatal Pyridoxine Therapy [PDF]

JIMD Rep
ABSTRACT Pyridox(am)ine‐5′‐phosphate oxidase (PNPO) deficiency is characterized by early‐onset epileptic encephalopathy refractory to standard antiseizure medications. It is caused by variants in the PNPO gene, resulting in deficient PNPO enzyme activity, which normally converts pyridoxine‐5′‐phosphate and pyridoxamine‐5′‐phosphate (two vitamers of ...
de Puyraimond C, Pichard S, Girard M, Delanne J, Faivre L, Imbard A, Baurand A, Benoist J, Mills P, Clayton P, Schiff M.   +10 more
europepmc   +2 more sources

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source