Sites of action of sleep and wake drugs: insights from model organisms [PDF]
Small molecules have been used since antiquity to regulate our sleep. Despite the explosion of diverse drugs to treat problems of too much or too little sleep, the detailed mechanisms of action and especially the neuronal targets by which these compounds
Rihel, J, Schier, AF
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Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives [PDF]
Aminoindanes, piperazines, and pipradrol derivatives are novel psychoactive substances found in "Ecstasy" tablets as replacements for 3,4-methylenedioxymethamphetamine (MDMA) or substances sold as "ivory wave." The pharmacology of these MDMA- and ...
Hoener, Marius C. +4 more
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Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs) [PDF]
N-2-methoxybenzyl-phenethylamines (NBOMe drugs) are newly used psychoactive substances with poorly defined pharmacological properties. The aim of the present study was to characterize the receptor binding profiles of a series of NBOMe drugs compared with
Buchy, Danièle +5 more
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Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues [PDF]
Chess-Williams, Russ +2 more
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Gut modulator effects of Conyza bonariensis explain its traditional use in constipation and diarrhea [PDF]
BACKGROUND AND OBJECTIVES: The current investigation was carried out to explore the pharmacological basis of the crude extract of Conyza bonariensis (Cb.Cr) for its use in constipation and diarrhea.
Bukhari, I A +5 more
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Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood-Brain Barrier. [PDF]
Kurosawa T +8 more
europepmc +1 more source
Cardioactive effects of diphenhydramine and curcumin in Daphnia magna [PDF]
Although used as a model for examining the cardioactive effects of various compounds, the neuromuscular regulation of the heart of the crustacean Daphnia magna (D. magna) is not well understood.
Avinash Vaidya +4 more
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Wakefulness is governed by GABA and histamine co-transmission [PDF]
Brickley, SG +12 more
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Neurotransmitters of sleep and wakefulness in flatworms. [PDF]
Omond SET, Hale MW, Lesku JA.
europepmc +1 more source
Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration. [PDF]
Park C +5 more
europepmc +1 more source

