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Ocular disposition of topically applied histamine, cimetidine, and pyrilamine in the albino rabbit

Current Eye Research, 1984
Aqueous solutions of pyrilamine, cimetidine, and histamine were instilled into the eyes of albino rabbits and drug levels determined as a function of time in the cornea, conjunctiva, aqueous humor, and iris-ciliary body. For all three drugs, less than 1% of the applied dose penetrates to the aqueous humor.
H W, Hui, L, Zeleznick, J R, Robinson
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Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats

Food and Chemical Toxicology, 1984
Methapyrilene hydrochloride was administered at levels of 125 or 250 ppm in the diet to groups of male and female F344 rats. The closely analogous antihistaminic drug pyrilamine, as the maleate, was given at 2000 ppm in the diet or at 2 g/litre drinking-water to groups of male and female F344 rats.
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[Research progress of pyrilamine-sensitive H~+/OC antiporter].

Yao xue xue bao = Acta pharmaceutica Sinica, 2018
In recent years, a new type of organic cation transporter has been found to transport organic cation drugs like pyrilamine, diphenhydramine and oxycodone in brain capillary endothelial cells, Caco-2 cells and other cells. Its transport activity can not be inhibited by typical organic cation transporter substrates or inhibitors, and its transport ...
Xin-yi, Wang, Zhi-rong, Zhang
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Efficacy of Cimetidine/Pyrilamine Eyedrops