Results 161 to 170 of about 1,692 (191)
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Effect of Cimetidine and Pyrilamine on Histamine-Induced Ocular Surface Hyperemia
Journal of Ocular Pharmacology and Therapeutics, 1986Histamine-induced ocular surface redness was virtually abolished by a combination of cimetidine (H2-receptor antagonist) and pyrilamine (H1-receptor antagonist), whereas either antagonist administered alone produced no significant reduction. It appears that combined H1- and H2-antagonist therapy is required for effective blockade of ocular responses to
D F, Woodward +3 more
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Identification of urinary metabolites of pyrilamine after oral administration to man
Xenobiotica, 19941. The metabolism of pyrilamine, 2-[4-methoxybenzyl-(2-dimethylaminoethyl) amino] pyridine, was studied in adult male volunteers after a single oral dose of 50 mg. 2. Solvent extracts of urine obtained with or without enzyme hydrolysis were analysed by gc/ms after derivatization with MSTFA/TMSCI (N-methyl-N-trimethylsilyl-trifluoroacetamide/trimethyl ...
B C, Chung +5 more
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The General Toxicology Unknown II. A Case Report: Doxylamine and Pyrilamine Intoxication
Journal of Forensic Sciences, 1983Abstract A general toxicology unknown case is presented to demonstrate our systematic approach. A 20-year-old male was found dead with multiple suicide notes. Overdose was suspected but substances were not known. Blood alcohol was negative.
N B, Wu Chen +5 more
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Ocular disposition of topically applied histamine, cimetidine, and pyrilamine in the albino rabbit
Current Eye Research, 1984Aqueous solutions of pyrilamine, cimetidine, and histamine were instilled into the eyes of albino rabbits and drug levels determined as a function of time in the cornea, conjunctiva, aqueous humor, and iris-ciliary body. For all three drugs, less than 1% of the applied dose penetrates to the aqueous humor.
H W, Hui, L, Zeleznick, J R, Robinson
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Antihistamine drugs on rat pregnancy: Effects of pyrilamine and meclizine
Life Sciences, 1963Abstract Pyrilamine administration in the early stages of pregnancy in the rat caused: a) an increase in the frequency of implantation anomalies and b) several toxic effects appearing in the last stages of pregnancy. Meclizine, on the other hand, had virtually no effects.
F. Bovet-Nitti, G. Bignami, D. Bovet
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Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats
Food and Chemical Toxicology, 1984Methapyrilene hydrochloride was administered at levels of 125 or 250 ppm in the diet to groups of male and female F344 rats. The closely analogous antihistaminic drug pyrilamine, as the maleate, was given at 2000 ppm in the diet or at 2 g/litre drinking-water to groups of male and female F344 rats.
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[Research progress of pyrilamine-sensitive H~+/OC antiporter].
Yao xue xue bao = Acta pharmaceutica Sinica, 2018In recent years, a new type of organic cation transporter has been found to transport organic cation drugs like pyrilamine, diphenhydramine and oxycodone in brain capillary endothelial cells, Caco-2 cells and other cells. Its transport activity can not be inhibited by typical organic cation transporter substrates or inhibitors, and its transport ...
Xin-yi, Wang, Zhi-rong, Zhang
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Journal of the American Pharmaceutical Association (Practical Pharmacy ed.), 1955
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