Results 141 to 150 of about 1,774 (189)
Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice [PDF]
Biopharmaceutics and Drug Disposition, 2009 Carnitine/organic cation transporter 2 (OCTN2) recognizes various cationic compounds as substrates in vitro, but information on its pharmacokinetic role in vivo is quite limited.
Yoshiyuki Kubo
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ACS Medicinal Chemistry Letters, 2018 We designed and synthesized a pyrilamine derivative 1 as a selective class I HDAC inhibitor that targets pyrilamine-sensitive proton-coupled organic cation antiporter (PYSOCA) at the blood–brain barrier (BBB).
Kei Higuchi +2 more
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Journal of Pharmaceutical Sciences, 1988
O-Demethylation of pyrilamine with l-propanethiol and potassium tert-butoxide gave hydroxytripelennamine, one of the major metabolites of tripelennamine. The reaction of pyrilamine with other demethylating agents has been explored and the products formed have been characterized.
F L, Hsu, S Y, Yeh, S, Munavalli
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O-Demethylation of pyrilamine with l-propanethiol and potassium tert-butoxide gave hydroxytripelennamine, one of the major metabolites of tripelennamine. The reaction of pyrilamine with other demethylating agents has been explored and the products formed have been characterized.
F L, Hsu, S Y, Yeh, S, Munavalli
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Dual effect of pyrilamine on absence seizures in WAG/Rij rats
Inflammation Research, 2005Inna Midzyanovskaya
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A Fatal Case Involving Pyrilamine
Clinical Toxicology, 1981AbstractA death attributed to ingestion of pyrilamine in over-the-counter sleep aids is reported. Tissue concentrations and methods for detection and quantitation are presented.
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The metabolism and elimination of pyrilamine maleate in the rat.
Drug Metabolism and Disposition, 1987The metabolism and elimination of pyrilamine (2-[(2-dimethylamino-ethyl)(p-methoxybenzyl)amino]pyridine) were characterized after the iv administration of 7.0 mg/kg or 0.7 mg/kg pyrilamine maleate plus [14C]pyrilamine maleate to adult male Fischer-344 rats.
D W, Kelly, W, Slikker
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Tablets of Pyrilamine Resin Adsorbate with Aspirin and Vitamin C
Journal of Pharmaceutical Sciences, 1962Marked changes in physical appearance manifested by dry formulations containing aspirin, an antihistamine, and vitamin C during an accelerated temperature stability study are discussed. The stabilization afforded by a resin adsorbate of a commonly used antihistamine, pyrilamine, is noted.
S, SIEGEL +3 more
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Chronic Feeding Study of Pyrilamine in Fischer 344 Rats
Fundamental and Applied Toxicology, 1995The antihistamine, pyrilamine maleate, was fed for up to 2 years to groups of 57 Fischer 344 (F344) rats of each sex at dietary levels of 0, 300, 1500, or 3000 ppm (free base). Eight or nine of these rats per sex and dose group were killed at 65 weeks to analyze hematology and clinical chemistry in all groups and histopathology of control and high-dose
D L, Greenman +4 more
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