Results 141 to 150 of about 1,692 (191)

Chronic Toxicity/Carcinogenicity Study of Pyrilamine in B6C3F1 Mice

Journal of the American College of Toxicology, 1995
The chronic toxicity and carcinogenicity of pyrilamine maleate were evaluated in B6C3F1 mice by feeding for up to 2 years to groups of 60 male or female mice at dietary levels of 0,150, 750, or 1,500 ppm (as the free base). Up to 12 mice per sex and dose group were killed after 65 weeks for clinical chemistry, hematology, and histopathologic ...
William T Allaben
exaly   +2 more sources

Pyrilamine

, 2007
S.J. Enna, David B. Bylund
openaire   +2 more sources

Design, Synthesis, and Blood–Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors

ACS Medicinal Chemistry Letters, 2018
We designed and synthesized a pyrilamine derivative 1 as a selective class I HDAC inhibitor that targets pyrilamine-sensitive proton-coupled organic cation antiporter (PYSOCA) at the blood–brain barrier (BBB).
Kei Higuchi, Yoshiharu Deguchi, Akihiro Itô   +2 more
exaly   +2 more sources

Physical and Biological Properties of Pyrilamine

Journal of Pharmaceutical Sciences, 1983
Thomas J Haley
exaly   +3 more sources

Pyrilamine

, 2018
openaire   +2 more sources

Pyrilamine/Caffeine/Acetaminophen

, 2020
openaire   +2 more sources

Efficacy of Cimetidine/Pyrilamine Eyedrops

Ophthalmology, 1986
Efraim Duzman
exaly   +2 more sources

Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice

Biopharmaceutics and Drug Disposition, 2009
Carnitine/organic cation transporter 2 (OCTN2) recognizes various cationic compounds as substrates in vitro, but information on its pharmacokinetic role in vivo is quite limited.
Yukio Kato, Tomoko Sugiura, Yoshiyuki Kubo   +2 more
exaly   +3 more sources

O-Demethylation of Pyrilamine

Journal of Pharmaceutical Sciences, 1988
O-Demethylation of pyrilamine with l-propanethiol and potassium tert-butoxide gave hydroxytripelennamine, one of the major metabolites of tripelennamine. The reaction of pyrilamine with other demethylating agents has been explored and the products formed have been characterized.
F L, Hsu, S Y, Yeh, S, Munavalli
openaire   +2 more sources

Dual effect of pyrilamine on absence seizures in WAG/Rij rats

Inflammation Research, 2005
Inna S Midzyanovskaya, G D Kuznetsova, L Tuomisto   +2 more
exaly   +3 more sources