Results 151 to 160 of about 1,774 (189)
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Journal of Labelled Compounds and Radiopharmaceuticals, 1985
AbstractPyrilamine‐d6 (N‐[(4‐methoxyphenyl)methyl]‐N′, N′‐di[2H3]methyl‐N‐2‐pyridinyl‐1,2‐ethanediamine) was synthesised from N‐2‐[(4‐methoxyphenyl)methyl]‐aminopyridine and 2‐(N,N‐di[2H3]methylamino)ethyl chloride in 83% yield. The alkyl chloride was prepared in 37% overall yield in a three step reaction from toluene‐4‐sulphondi [2H3]methylamide.
Ian Bird, David E G Shuker
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AbstractPyrilamine‐d6 (N‐[(4‐methoxyphenyl)methyl]‐N′, N′‐di[2H3]methyl‐N‐2‐pyridinyl‐1,2‐ethanediamine) was synthesised from N‐2‐[(4‐methoxyphenyl)methyl]‐aminopyridine and 2‐(N,N‐di[2H3]methylamino)ethyl chloride in 83% yield. The alkyl chloride was prepared in 37% overall yield in a three step reaction from toluene‐4‐sulphondi [2H3]methylamide.
Ian Bird, David E G Shuker
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Pyrilamine-Induced Prolonged QT Interval in Adolescent With Drug Overdose
Pediatric Emergency Care, 2011The widespread availability of antihistamines in many over-the-counter preparations can lead to significant hazard to the public because of their possible link to potential ventricular arrhythmias secondary to prolongation of QT interval. The effect can be further compounded by the use of other commonly used medications such as macrolides, antifungal ...
Govinda, Paudel +3 more
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Simultaneous Spectrophotometric Determination of Pyrilamine Maleate and Quinine
Bulletin (Society for Applied Spectroscopy), 1951The inclusion of the recently developed antihistamines in cold tablets has led to the interesting problem of quantitatively estimating constituents which have very similar chemical and physical properties. Formulations have appeared containing aspirin, caffeine, phenacetin, and quinine hydrobromide in combination with the well established ...
J. D. Neuss +2 more
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Subchronic Studies of Pyrilamine in Fischer 344 Rats
Journal of the American College of Toxicology, 1993This study was designed to determine the subchronic effects of the antihistamine, pyrilamine maleate, and to establish dose levels for a 2-year chronic study. Six male and six female F344 rats received dietary pyrilamine concentrations of 0, 392, 783, 1563, 3122, or 6276 ppm (as the free base) for 14 days.
David L. Greenman +3 more
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Identification of Pyrilamine Metabolites by Ammonia Chemical Ionization Mass Spectrometry
Journal of Analytical Toxicology, 1986The ammonia chemical ionization mass spectrometric analysis of pyrilamine, the N-oxide of pyrilamine, and related compounds is described. The use of ammonia as the reagent gas produced excellent [M + H]+ ions for these compounds. The suitability of this method for the analysis of two rat urinary metabolites of pyrilamine is demonstrated.
W A, Korfmacher +3 more
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Effect of Cimetidine and Pyrilamine on Histamine-Induced Ocular Surface Hyperemia
Journal of Ocular Pharmacology and Therapeutics, 1986Histamine-induced ocular surface redness was virtually abolished by a combination of cimetidine (H2-receptor antagonist) and pyrilamine (H1-receptor antagonist), whereas either antagonist administered alone produced no significant reduction. It appears that combined H1- and H2-antagonist therapy is required for effective blockade of ocular responses to
D F, Woodward +3 more
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Identification of urinary metabolites of pyrilamine after oral administration to man
Xenobiotica, 19941. The metabolism of pyrilamine, 2-[4-methoxybenzyl-(2-dimethylaminoethyl) amino] pyridine, was studied in adult male volunteers after a single oral dose of 50 mg. 2. Solvent extracts of urine obtained with or without enzyme hydrolysis were analysed by gc/ms after derivatization with MSTFA/TMSCI (N-methyl-N-trimethylsilyl-trifluoroacetamide/trimethyl ...
B C, Chung +5 more
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Journal of Pharmaceutical Sciences, 1969
The experiments described herein were performed on isolated, spontaneously beating rabbit atria. The muscarinic actions of acetylcholine in the presence of physostigmine were antagonized by pyrilamine, chlorpheniramine and procaine which demonstrates that these drugs have an “antimuscarinic” action.
R E, Osterberg, T, Koppanyi
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The experiments described herein were performed on isolated, spontaneously beating rabbit atria. The muscarinic actions of acetylcholine in the presence of physostigmine were antagonized by pyrilamine, chlorpheniramine and procaine which demonstrates that these drugs have an “antimuscarinic” action.
R E, Osterberg, T, Koppanyi
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Antihistamine drugs on rat pregnancy: Effects of pyrilamine and meclizine
Life Sciences, 1963Abstract Pyrilamine administration in the early stages of pregnancy in the rat caused: a) an increase in the frequency of implantation anomalies and b) several toxic effects appearing in the last stages of pregnancy. Meclizine, on the other hand, had virtually no effects.
F. Bovet-Nitti, G. Bignami, D. Bovet
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The General Toxicology Unknown II. A Case Report: Doxylamine and Pyrilamine Intoxication
Journal of Forensic Sciences, 1983Abstract A general toxicology unknown case is presented to demonstrate our systematic approach. A 20-year-old male was found dead with multiple suicide notes. Overdose was suspected but substances were not known. Blood alcohol was negative.
N B, Wu Chen +5 more
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