Results 191 to 200 of about 3,638 (238)
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Identification of Pyrilamine Metabolites by Ammonia Chemical Ionization Mass Spectrometry
Journal of Analytical Toxicology, 1986The ammonia chemical ionization mass spectrometric analysis of pyrilamine, the N-oxide of pyrilamine, and related compounds is described. The use of ammonia as the reagent gas produced excellent [M + H]+ ions for these compounds. The suitability of this method for the analysis of two rat urinary metabolites of pyrilamine is demonstrated.
Harold C. Thompson +3 more
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Simultaneous Spectrophotometric Determination of Pyrilamine Maleate and Quinine
Bulletin (Society for Applied Spectroscopy), 1951The inclusion of the recently developed antihistamines in cold tablets has led to the interesting problem of quantitatively estimating constituents which have very similar chemical and physical properties. Formulations have appeared containing aspirin, caffeine, phenacetin, and quinine hydrobromide in combination with the well established ...
G.E. Herpich, J.D. Neuss, H.A. Frediani
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Chronic Feeding Study of Pyrilamine in Fischer 344 Rats
Fundamental and Applied Toxicology, 1995The antihistamine, pyrilamine maleate, was fed for up to 2 years to groups of 57 Fischer 344 (F344) rats of each sex at dietary levels of 0, 300, 1500, or 3000 ppm (free base). Eight or nine of these rats per sex and dose group were killed at 65 weeks to analyze hematology and clinical chemistry in all groups and histopathology of control and high-dose
William T. Allaben +4 more
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Toxicology and Applied Pharmacology, 1995
Methapyrilene (MPH) was a widely used antihistamine until it was found to produce hepatocellular carcinoma and cholangiocarcinoma in Fischer 344 rats. The structurally similar antihistamine pyrilamine (PYR) was marginally or noncarcinogenic in a similar ...
Michael L. Cunningham +3 more
semanticscholar +1 more source
Methapyrilene (MPH) was a widely used antihistamine until it was found to produce hepatocellular carcinoma and cholangiocarcinoma in Fischer 344 rats. The structurally similar antihistamine pyrilamine (PYR) was marginally or noncarcinogenic in a similar ...
Michael L. Cunningham +3 more
semanticscholar +1 more source
Tablets of Pyrilamine Resin Adsorbate with Aspirin and Vitamin C
Journal of Pharmaceutical Sciences, 1962Marked changes in physical appearance manifested by dry formulations containing aspirin, an antihistamine, and vitamin C during an accelerated temperature stability study are discussed. The stabilization afforded by a resin adsorbate of a commonly used antihistamine, pyrilamine, is noted.
Roy H. Reiner +3 more
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Journal of Pharmacy and Science, 1977
The quantitative determinations of codeine phosphate, guaifenesin, pheniramine maleate, phenylpropanolamine hydrochloride, and pyrilamine maleate in a liquid dosage form are described.
V. Gupta, A. Ghanekar
semanticscholar +1 more source
The quantitative determinations of codeine phosphate, guaifenesin, pheniramine maleate, phenylpropanolamine hydrochloride, and pyrilamine maleate in a liquid dosage form are described.
V. Gupta, A. Ghanekar
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Inhibition of orexin-induced wakefulness by pyrilamine, an H1 receptor antagonist
Sleep and Biological Rhythms, 2004 Natsuko Tsujino +3 more
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Identification of urinary metabolites of pyrilamine after oral administration to man
Xenobiotica, 19941. The metabolism of pyrilamine, 2-[4-methoxybenzyl-(2-dimethylaminoethyl) amino] pyridine, was studied in adult male volunteers after a single oral dose of 50 mg. 2. Solvent extracts of urine obtained with or without enzyme hydrolysis were analysed by gc/ms after derivatization with MSTFA/TMSCI (N-methyl-N-trimethylsilyl-trifluoroacetamide/trimethyl ...
Bong Chul Chung +5 more
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