Results 91 to 100 of about 43,381 (288)

Genome comparison of progressively drug resistant Plasmodium falciparum lines derived from drug sensitive clone

Memorias do Instituto Oswaldo Cruz, 2001
Chloroquine has been the mainstay of malaria chemotherapy for the past five decades, but resistance is now widespread. Pyrimethamine or proguanil form an important component of some alternate drug combinations being used for treatment of uncomplicated ...
Ravi Toteja, Lathika Nair, VK Bhasin
doaj   +1 more source

Assessment of the Teratogenic Effect of Sulfadoxine-Pyrimethamine on the Chicken Embryo

Journal of Toxicology, 2022
Background. The sulfadoxine-pyrimethamine combination is a product used in the intermittent preventive treatment (IPT) of malaria in pregnant women in our country. To date, there is very little data on the teratogenic effect of this product.
Rachida Moussa Tari, Aboudoulatif Diallo, Emmanuelle Kouame, Phénix Assogba, Essotolom Badjabaissi, Lawson-Evi Povi, Batomayena Bakoma, Yao Potchoo, Kokou Tona   +8 more
doaj   +1 more source

Frequency of Pfcrt T76 and Pfdhfr Asn-108 Drug Resistance Mutations in falciparum Malaria in Southeastern Malaria Endemic Area of Iran [PDF]

Iranian Journal of Public Health, 2008
Background: Point mutations in the genes, Pfcrt and Pfdhfr, have been identified elsewhere as strongly associated with re­sistance to chloroquine (CQ) and pyrimethamine, respectively.
MR Razavi, SR Naddaf, JLe Bras, A Raesi, AR Esmaeili, M Assmar   +5 more
doaj   +1 more source

S3‐Leitlinie zur Therapie der Psoriasis vulgaris, adaptiert von EuroGuiDerm – Teil 1: Therapieempfehlungen und Monitoring

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 1, Page 122-139, January 2026.
Zusammenfassung Der vorliegende Teil 1 der Aktualisierung der S3‐Leitlinie zur Therapie der Psoriasis vulgaris umfasst die Abschnitte „Therapieempfehlungen“, „Therapieziele“ sowie die „Monitoringempfehlungen“ zu den Therapien. Die Grundlage bildet die aktuelle Cochrane‐Netzwerkmetaanalyse, deren Ergebnisse ebenfalls dargestellt werden.
Alexander Nast, Andreas Altenburg, Matthias Augustin, Frank Bachmann, Wolf‐Henning Boehncke, Markus Cornberg, Hilte Geerdes‐Fenge, Brit Häcker, Peter Härle, Joachim Klaus, Michaela Köhm, Arno Köllner, Ulrich Mrowietz, Hans‐Michael Ockenfels, Antonia Pennitz, Sandra Philipp, Thomas Richter, Thomas Rosenbach, Tom Schaberg, Martin Schlaeger, Gerhard Schmid‐Ott, Michael Sebastian, Karisa Thölken, Ralph von Kiedrowski, Uwe Willuhn, Christoph Zeyen   +25 more
wiley   +1 more source

Efficacy of pyrimethamine-sulfadoxine in young children with uncomplicated falciparum malaria in rural Burkina Faso

Malaria Journal, 2004
The efficacy of pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in young children of a malaria holoendemic area in rural Burkina Faso is reported.
Traore Corneille, Müller Olaf, Kouyate Bocar   +2 more
doaj   +1 more source

Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data meta-analysis. [PDF]

EClinicalMedicine
Summary: Background: High-grade Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in east and southern Africa has prompted trials evaluating intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine as an ...
Roh ME, Gutman JR, Murphy M, Hill J, Madanitsa M, Kakuru A, Barsosio HC, Kariuki S, Lusingu JPA, Mosha F, Kajubi R, Kamya MR, Mathanga D, Chinkhumba J, Laufer MK, Mlugu E, Kamuhabwa AAR, Aklillu E, Minzi O, Okoro RN, Geidam AD, Ohieku JD, Desai M, Jagannathan P, Dorsey G, Ter Kuile FO.   +25 more
europepmc   +2 more sources

Factors Associated with Severe Disease from Malaria, Pneumonia and Diarrhea among Children in Rural Tanzania - a Hospital-Based Cross-Sectional Study. [PDF]

, 2012
Mild cases of malaria, pneumonia and diarrhea are readily treatable with complete recovery and with inexpensive and widely available first-line drugs. However, treatment is complicated and expensive, and mortality is higher when children present to the ...
Hinderaker, Sven Gudmund, Kahabuka, Catherine, Kvåle, Gunnar   +2 more
core   +2 more sources

Identification of Fis1 Interactors in Toxoplasma gondii Reveals a Novel Protein Required for Peripheral Distribution of the Mitochondrion [PDF]

, 2020
Toxoplasma gondii’s single mitochondrion is very dynamic and undergoes morphological changes throughout the parasite’s life cycle. During parasite division, the mitochondrion elongates, enters the daughter cells just prior to cytokinesis, and undergoes ...
Arrizabalaga, Gustavo, Charvat, Robert, Jacobs, Kylie   +2 more
core   +1 more source

Use of thin-layer chromatography to detect counterfeit sulfadoxine/pyrimethamine tablets with the wrong active ingredient in Malawi

Malaria Journal, 2016
Substandard and falsified anti-malarial medicines pose a serious threat to public health, especially in low-income countries. Appropriate technologies for drug quality analysis in resource-limited settings are important for the surveillance of the formal
Felix Khuluza, Stephen Kigera, R. Jähnke, L. Heide   +3 more
semanticscholar   +1 more source

Malaria‐Associated Acute Kidney Injury in a Low‐Endemic Region: A Case Series of Five Imported Plasmodium falciparum Infections

Case Reports in Infectious Diseases, Volume 2026, Issue 1, 2026.
Malaria‐associated acute kidney injury (MAKI) is a formidable and potentially fatal complication of malaria. Early recognition and timely management can significantly reduce morbidity and mortality, particularly in resource‐limited settings. This case series describes five patients with imported Plasmodium falciparum complicated by MAKI who were ...
Daniel P. Mujuni, Abid M. Sadiq, Elisha Luhwago, Datius Mutalemwa, Abel Mwanga, Leanji Leonard, Elifuraha W. Mkwizu, Elichilia R. Shao, Kajiru G. Kilonzo, Mohamed A. Dkhil   +9 more
wiley   +1 more source