Results 91 to 100 of about 41,516 (300)
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 4, Page 738-750, April 2025.ABSTRACT Treatment of breastfeeding mothers with malaria is challenging due to the lack of information describing drug exposure in milk and the daily dose to the breastfed infant. Physiologically based pharmacokinetic (PBPK) modeling was used to predict milk‐to‐plasma (M/P) ratios, infant daily doses (IDD) and relative infant doses (RID) for five ...
Lisa M. Almond +11 more
wiley +1 more source
Malaria Journal, 2004 The efficacy of pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in young children of a malaria holoendemic area in rural Burkina Faso is reported.
Traore Corneille +2 more
doaj +1 more source
Drug resistance in Plasmodium falciparum from the Chittagong Hill Tracts, Bangladesh. [PDF]
, 2004 OBJECTIVE: To assess the efficacy of antimalarial treatment and molecular markers of Plasmodium falciparum resistance in the Chittagong Hill Tracts of Bangladesh. METHODS: A total of 203 patients infected with P.
Anderson, T C +6 more
core +2 more sources
Storage of Pyrimethamine in Cells in vitro.
Experimental Biology and Medicine, 1958 Summary1. Storage of pyrimethamine or active products of pyrimethamine occurs in tissue cultures of monkey kidney treated with the drug. This has been demonstrated by parasite challenges of treated cultures and by microbiological assay with Streptococcus faecalis R. 2. The limits of this storage phenomenon have been defined. 3.
Jacobs L, Cook Mk
openaire +3 more sources
British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 968-980, April 2025.Infants bear a significant malaria burden but are usually excluded from participating in early dose optimization studies that inform dosing regimens of antimalarial therapy. Unlike older children, infants' exclusion from early‐phase trials has resulted in limited evidence to guide accurate dosing of antimalarial treatment for uncomplicated malaria or ...
Clifford G. Banda +2 more
wiley +1 more source
BMC Medicine, 2015 BackgroundIntermittent preventive treatment in pregnancy has not been evaluated outside of Africa. Low birthweight (LBW,
H. Unger +20 more
semanticscholar +1 more source
A new effective antiplasmodial compound: Nanoformulated pyrimethamine
Journal of Global Antimicrobial Resistance, 2020 Objectives: The aim of this study was to evaluate the efficacy of pyrimethamine-loaded poloxamer 407 nanomicelles on Plasmodium berghei strain NICD in vivo.
Nader Pestehchian +6 more
doaj
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 3, Page 161-168, March 2025.Abstract Introduction The use of serum creatinine (SCr) for drug dosing has significant limitations and is influenced by many non‐kidney factors. Cystatin C (cysC) is an alternative or additional marker of kidney function that is less affected by non‐kidney factors. Although cysC may be useful in hospitalized patients, the use of cysC to calculate drug
Victoria L. Williams, Anthony T. Gerlach
wiley +1 more source
High prevalence of double Plasmodium falciparum dhfr mutations at codons 108 and 59 in the Sistan-Baluchistan province, Iran [PDF]
, 2003 info:eu-repo/semantics ...
Bereckzy, S +4 more
core +1 more source
Serious Adverse Drug Reactions to Pyrimethamine-Sulphadoxine, Pyrimethamine-Dapsone and to Amodiaquine in Britain [PDF]
Journal of the Royal Society of Medicine, 1990 All reports of adverse reactions with pyrimethamine-sulphadoxine (Fansidar), pyrimethamine-dapsone (Maloprim), and amodiaquine spontaneously reported through the UK national post-marketing system were reviewed. Retrospective reporting rates of serious reactions associated with these drugs were analysed using prescription data from the Department of ...
L J West, P A Phillips-Howard
openaire +3 more sources