Results 91 to 100 of about 16,646 (111)

P. berghei telomerase subunit TERT is essential for parasite survival [PDF]

, 2014
Telomeres define the ends of chromosomes protecting eukaryotic cells from chromosome instability and eventual cell death. The complex regulation of telomeres involves various proteins including telomerase, which is a specialized ribonucleoprotein ...
Janse, Chris J., Ramesar, Jai, Religa, Agnieszka, Scherf, Artur, Waters, Andrew P.   +4 more
core   +3 more sources

Traitement préventif intermittent à la sulfadoxine à pyriméthamine du paludisme chez les femmes enceintes: efficacité et observance dans deux hôpitaux urbains du Burkina Faso

The Pan African Medical Journal, 2013
INTRODUCTION: La présente étude prospective se propose d'évaluer l'efficacité thérapeutique du traitement préventif intermittent à la sulfadoxine pyriméthamine et son observance chez la femme enceinte dans deux hôpitaux urbains au Burkina Faso. METHODES:
Sanata Bamba, Adama Séré, Rodrigues Nikiéma, Tinto Halidou, Blandine Thieba, Blami Dao, Robert Tinga Guiguemdé   +6 more
doaj   +1 more source

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? [PDF]

, 2006
The organization and mining of malaria genomic and post-genomic data is highly motivated by the necessity to predict and characterize new biological targets and new drugs. Biological targets are sought in a biological space designed from the genomic data
Bastien, Olivier, Birkholtz, Lyn-Marie, Breton, Vincent, Grando, Delphine, Hofmann-Apitius, Martin, Jacq, Nicolas, Joubert, Fourie, Kasam, Vinod, Louw, Abraham I, Maréchal, Eric, Ortet, Philippe, Roy, Sylvaine, Saïdani, Nadia, Wells, Gordon, Zimmermann, Marc   +14 more
core   +4 more sources

Effects of amodiaquine and artesunate on sulphadoxine-pyrimethamine pharmacokinetic parameters in children under five in Mali

Malaria Journal, 2011
Background Sulphadoxine-pyrimethamine, in combination with artesunate or amodiaquine, is recommended for the treatment of uncomplicated malaria and is being evaluated for intermittent preventive treatment.
Doumbo Ogobara K, Traore Zoumana I, Smith Peter, Maiga Hamma, Evans Alicia, Sangare Cheick PO, Beavogui Abdoul H, Fredericks Alfia, Toure Sékou, Tekete Mamadou M, Barnes Karen I, Djimde Abdoulaye A   +11 more
doaj   +1 more source

Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine: pharmacokinetic and dosage-related findings from a clinical trial in Uganda. [PDF]

, 2006
BACKGROUND: A six-dose antimalarial regimen of artemether-lumefantrine (A/L) may soon become one of the most widely used drug combination in Africa, despite possible constraints with adherence and poor absorption due to inadequate nutrition, and a lack ...
Babigumira, J, Bajunirwe, F, Biraro, S, Checchi, F, Ferradini, L, Fogg, C, Grandesso, F, Guthmann, J P, Kigozi, I, Kiguli, J, Kyomuhendo, J, Piola, P, Ruzagira, E, Taylor, W R J   +13 more
core   +3 more sources

Efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria: revisiting molecular markers in an area of emerging AQ and SP resistance in Mali

Malaria Journal, 2009
Background To update the National Malaria Control Programme of Mali on the efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria.
Wele Mamadou, Dembele Demba, Kone Aminatou, Dama Souleymane, Ouologuem Dinkorma, Fofana Bakary, Sagara Issaka, Maiga Hamma, Beavogui Abdoul H, Djimde Abdoulaye A, Tekete Mamadou, Dicko Alassane, Doumbo Ogobara K   +12 more
doaj   +1 more source

Therapeutic efficacy test in malaria falciparum in Antioquia, Colombia

Malaria Journal, 2006
Objective Evaluate the frequency of failure of eight treatments for non-complicated malaria caused by Plasmodium falciparum in patients from Turbo (Urabá region), El Bagre and Zaragoza (Bajo Cauca region), applying the 1998 protocol of the World Health ...
Álvarez Tania, Ríos Alexandra, Piñeros Juan G, Carmona-Fonseca Jaime, Blair Silvia, Álvarez Gonzalo, Tobón Alberto   +6 more
doaj   +1 more source

The characteristic structural and functional dynamics of P. falciparum DHFR binding with pyrimidine chemotypes implicate malaria therapy design

Chemical Physics Impact
Dihydrofolate reductase (DHFR) enzyme regulates de-novo folate synthesis in Plasmodium falciparum, hence a critical malaria drug target. Pyrimethamine inhibits DHFR, but resistance and lack of cross-species activity are key challenges.
Wande M. Oluyemi, Goodness Nwokebu, Adeniyi T. Adewumi, Shadrach C. Eze, Chinedu C. Mbachu, Emmanuel C. Ogueli, Ngozi Nwodo, Mahmoud E.S. Soliman, Salerwe Mosebi   +8 more
doaj   +1 more source

Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data meta-analysisResearch in context

EClinicalMedicine
Summary: Background: High-grade Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in east and southern Africa has prompted trials evaluating intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine as an ...
Michelle E. Roh, Julie R. Gutman, Maxwell Murphy, Jenny Hill, Mywayiwawo Madanitsa, Abel Kakuru, Hellen C. Barsosio, Simon Kariuki, John P.A. Lusingu, Frank Mosha, Richard Kajubi, Moses R. Kamya, Don Mathanga, Jobiba Chinkhumba, Miriam K. Laufer, Eulambius Mlugu, Appolinary A.R. Kamuhabwa, Eleni Aklillu, Omary Minzi, Roland Nnaemeka Okoro, Ado Danazumi Geidam, John David Ohieku, Meghna Desai, Prasanna Jagannathan, Grant Dorsey, Feiko O. ter Kuile   +25 more
doaj   +1 more source

Analysis of the dihydrofolate reductase-thymidylate synthase gene sequences in Plasmodium vivax field isolates that failed chloroquine treatment

Malaria Journal, 2010
Background To use pyrimethamine as an alternative anti-malarial drug for chloroquine-resistant malaria parasites, it was necessary to determine the enzyme's genetic variation in dihydrofolate reductase-thymidylate syntase (DHFR-TS) among Korean strains ...
Kim Hyuck, Sohn Youngjoo, Sattabongkot Jetsumon, Kim Jung-Yeon, Kim Mi-A, Choi Kyung-Mi, Choi Yien-Kyoung, Kim Hyung-Hwan, Lee Won-Ja, Lee Jong-Koo, Park Han-Sook, Lee Hyeong-Woo   +11 more
doaj   +1 more source