Results 91 to 100 of about 42,597 (297)
Storage of Pyrimethamine in Cells in vitro.
Experimental Biology and Medicine, 1958 Summary1. Storage of pyrimethamine or active products of pyrimethamine occurs in tissue cultures of monkey kidney treated with the drug. This has been demonstrated by parasite challenges of treated cultures and by microbiological assay with Streptococcus faecalis R. 2. The limits of this storage phenomenon have been defined. 3.
Jacobs L, Cook Mk
openaire +3 more sources
ChemMedChem, Volume 20, Issue 19, October 6, 2025.Novel C1'‐branched acyclic nucleoside phosphonates were synthesized. The compounds are inhibitors of Plasmodium falciparum and human 6‐oxopurine phosphoribosyltransferases with Ki values as low as 0.4 µM and 0.7 µM, respectively. A phosphonodiamidate prodrug exhibited IC50 = 4.3 µM against a drug‐sensitive strain of P.
Jan Frydrych +11 more
wiley +1 more source
Frequency of Pfcrt T76 and Pfdhfr Asn-108 Drug Resistance Mutations in falciparum Malaria in Southeastern Malaria Endemic Area of Iran [PDF]
Iranian Journal of Public Health, 2008 Background: Point mutations in the genes, Pfcrt and Pfdhfr, have been identified elsewhere as strongly associated with resistance to chloroquine (CQ) and pyrimethamine, respectively.
MR Razavi +5 more
doaj +1 more source
Malaria Journal, 2004 The efficacy of pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in young children of a malaria holoendemic area in rural Burkina Faso is reported.
Traore Corneille +2 more
doaj +1 more source
Assessment of the Teratogenic Effect of Sulfadoxine-Pyrimethamine on the Chicken Embryo
Journal of Toxicology, 2022 Background. The sulfadoxine-pyrimethamine combination is a product used in the intermittent preventive treatment (IPT) of malaria in pregnant women in our country. To date, there is very little data on the teratogenic effect of this product.
Rachida Moussa Tari +8 more
doaj +1 more source
A STUDY ON TOXICITY OF PYRIMETHAMINE FOR CHICKS
The Japanese Journal of Veterinary Science, 1968 Chicks were given 0, 3, 9, and 27 ppm of pyrimethamine contained in a diet for12 consecutive weeks and examined both clinically and histopathologically. The healingprocess of the pyrimethamine-induced Iesion was also observed.l. Clinically, chicks exhibited remarkable hyperchromic anemia and retardedgrowth after 27 ppm administration.
Seigo Isogai +3 more
openaire +4 more sources
Malaria Journal, 2016 Substandard and falsified anti-malarial medicines pose a serious threat to public health, especially in low-income countries. Appropriate technologies for drug quality analysis in resource-limited settings are important for the surveillance of the formal
Felix Khuluza +3 more
semanticscholar +1 more source
Maternal &Child Nutrition, Volume 21, Issue 4, October 2025.Globally nearly 40% of children under 5 years old are anaemic, which affects their ability to grow and develop. A cluster randomised trial was conducted in 60 communities in Southern Mali to evaluate the added impact of home fortification with micronutrient powders, delivered alongside seasonal malaria chemoprevention, on anaemia, malaria infection ...
Niélé H. Diarra +18 more
wiley +1 more source
Adherence to a Six-Dose Regimen of Artemether-Lumefantrine for Treatment of Uncomplicated Plasmodium Falciparum Malaria in Uganda. [PDF]
, 2004 Measuring baseline levels of adherence and identifying risk factors for non-adherence are important steps before the introduction of new antimalarials. In Mbarara in southwestern Uganda, we assessed adherence to artemether-lumefantrine (Coartem) in its ...
Bajunirwe, F +9 more
core +2 more sources
BMC Medicine, 2015 BackgroundIntermittent preventive treatment in pregnancy has not been evaluated outside of Africa. Low birthweight (LBW,
H. Unger +20 more
semanticscholar +1 more source