Results 101 to 110 of about 34,530 (252)

Efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria: revisiting molecular markers in an area of emerging AQ and SP resistance in Mali

Malaria Journal, 2009
Background To update the National Malaria Control Programme of Mali on the efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria.
Wele Mamadou, Dembele Demba, Kone Aminatou, Dama Souleymane, Ouologuem Dinkorma, Fofana Bakary, Sagara Issaka, Maiga Hamma, Beavogui Abdoul H, Djimde Abdoulaye A, Tekete Mamadou, Dicko Alassane, Doumbo Ogobara K   +12 more
doaj   +1 more source

Short report: molecular markers associated with Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in the Democratic Republic of Congo. [PDF]

, 2006
Sulfadoxine-pyrimethamine (SP) is the first line antimalarial treatment in the Democratic Republic of Congo. Using polymerase chain reaction, we assessed the prevalence of mutations in the dihydrofolate reductase (dhfr) (codons 108, 51, 59) and ...
Bonnet, M, Cohuet, S, D'Alessandro, U, Guthmann, J P, Van Herp, M, Van Overmeir, C   +5 more
core   +2 more sources

Can field-based mosquito feeding assays be used for evaluating transmission-blocking interventions?

, 2012
A recent meta-analysis of mosquito feeding assays to determine the Plasmodium falciparum transmission potential of naturally infected gametocyte carriers highlighted considerable variation in transmission efficiency between assay methodologies and ...
Bousema, Teun, Churcher, Thomas S, Dinglasan, Rhoel R, Morlais, Isabelle   +3 more
core   +4 more sources

Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy [PDF]

, 2012
Julie Gutman, S. Patrick Kachur, Laurence Slutsker, Alexis Nzila, Theonest K. Mutabingwa   +4 more
openalex   +1 more source

The characteristic structural and functional dynamics of P. falciparum DHFR binding with pyrimidine chemotypes implicate malaria therapy design

Chemical Physics Impact
Dihydrofolate reductase (DHFR) enzyme regulates de-novo folate synthesis in Plasmodium falciparum, hence a critical malaria drug target. Pyrimethamine inhibits DHFR, but resistance and lack of cross-species activity are key challenges.
Wande M. Oluyemi, Goodness Nwokebu, Adeniyi T. Adewumi, Shadrach C. Eze, Chinedu C. Mbachu, Emmanuel C. Ogueli, Ngozi Nwodo, Mahmoud E.S. Soliman, Salerwe Mosebi   +8 more
doaj   +1 more source

Therapeutic efficacy test in malaria falciparum in Antioquia, Colombia

Malaria Journal, 2006
Objective Evaluate the frequency of failure of eight treatments for non-complicated malaria caused by Plasmodium falciparum in patients from Turbo (Urabá region), El Bagre and Zaragoza (Bajo Cauca region), applying the 1998 protocol of the World Health ...
Álvarez Tania, Ríos Alexandra, Piñeros Juan G, Carmona-Fonseca Jaime, Blair Silvia, Álvarez Gonzalo, Tobón Alberto   +6 more
doaj   +1 more source

Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data meta-analysisResearch in context

EClinicalMedicine
Summary: Background: High-grade Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in east and southern Africa has prompted trials evaluating intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine as an ...
Michelle E. Roh, Julie R. Gutman, Maxwell Murphy, Jenny Hill, Mywayiwawo Madanitsa, Abel Kakuru, Hellen C. Barsosio, Simon Kariuki, John P.A. Lusingu, Frank Mosha, Richard Kajubi, Moses R. Kamya, Don Mathanga, Jobiba Chinkhumba, Miriam K. Laufer, Eulambius Mlugu, Appolinary A.R. Kamuhabwa, Eleni Aklillu, Omary Minzi, Roland Nnaemeka Okoro, Ado Danazumi Geidam, John David Ohieku, Meghna Desai, Prasanna Jagannathan, Grant Dorsey, Feiko O. ter Kuile   +25 more
doaj   +1 more source

A Randomized Open-Label Evaluation of the Antimalarial Prophylactic Efficacy of Azithromycin-Piperaquine versus Sulfadoxine-Pyrimethamine in Pregnant Papua New Guinean Women [PDF]

, 2019
Brioni R. Moore, John Benjamin, Roselyn Tobe, Maria Ome‐Kaius, Gumul Yadi, Bernadine Kasian, Charles Kong, Leanne J. Robinson, Moses Laman, Ivo Müeller, Stephen J. Rogerson, Timothy M. E. Davis   +11 more
openalex   +1 more source

Effect of monthly intermittent preventive treatment with dihydroartemisinin–piperaquine with and without azithromycin versus monthly sulfadoxine–pyrimethamine on adverse pregnancy outcomes in Africa: a double-blind randomised, partly placebo-controlled trial

, 2023
Mwayiwawo Madanitsa, Hellen C. Barsosio, Daniel T. R. Minja, George Mtove, Reginald A. Kavishe, James Dodd, Queen Saidi, Eric D Onyango, Kephas Otieno, Duolao Wang, Per Ashorn, Jenny Hill, Crispin Mukerebe, Samwel Gesase, Omari Abdul Msemo, Victor Mwapasa, Kamija S. Phiri, Kenneth Maleta, Nigel Klein, Pascal Magnussen, John Lusingu, Simon Kariuki, Jacklin F Mosha, Michael Alifrangis, Helle Hansson, Christentze Schmiegelow, Julie Gutman, R Matthew Chico, Feiko O. ter Kuile   +28 more
openalex   +1 more source

The A581GMutation in the Gene EncodingPlasmodium falciparumDihydropteroate Synthetase Reduces the Effectiveness of Sulfadoxine-Pyrimethamine Preventive Therapy in Malawian Pregnant Women [PDF]

, 2015
Julie Gutman, Linda Kalilani, Steve M. Taylor, Zhiyong Zhou, Ryan E. Wiegand, Kyaw L. Thwai, Dyson Mwandama, Carole Khairallah, Mwayi Madanitsa, Ebbie Chaluluka, Fraction K. Dzinjalamala, Doreen Ali, Don P. Mathanga, Jacek Skarbinski, Ya Ping Shi, Steve Meshnick, Feiko O. ter Kuile   +16 more
openalex   +1 more source