Results 101 to 110 of about 41,516 (300)

Evaluation of the Landscape of Pharmacodynamic Biomarkers in GM1 and GM2 Gangliosidosis

Clinical and Translational Science, Volume 18, Issue 3, March 2025.
ABSTRACT GM1 and GM2 gangliosidosis are inherited, progressive, neurodegenerative lysosomal disorders of variable onset and disease progression. GM1 gangliosidosis is a result of biallelic pathogenic variants in the GLB1 gene, which confer absent or reduced β‐galactosidase enzyme activity and lead to the accumulation of glycoconjugates such as ...
Sydney Stern, Karryn Crisamore, Ruo‐Jing Li, Michael Pacanowski, Robert Schuck   +4 more
wiley   +1 more source

Artemisinin-based combination therapy does not measurably reduce human infectiousness to vectors in a setting of intense malaria transmission [PDF]

, 2012
<p>Background: Artemisinin-based combination therapy (ACT) for treating malaria has activity against immature gametocytes. In theory, this property may complement the effect of terminating otherwise lengthy malaria infections and reducing the ...
Abdulla, S.K., Charlwood, D.J., Ferguson, H., Huho, B.J., Kachur, S.P., Kihonda, A., Kihonda, J., Killeen, G.F., Lengeler, C., Smith, T., Tami, A.   +10 more
core   +6 more sources

A Novel Nuclear Protein Complex Controlling the Expression of Developmentally Regulated Genes in Toxoplasma Gondii

Advanced Science, Volume 12, Issue 7, February 17, 2025.
Toxoplasma gondii is a ubiquitous pathogen infecting billions of people and numerous animals. It has a complex life cycle with multiple developmental stages that facilitate its transmission. This study reports the key role of an AP2 family transcription factor called AP2XII‐5, by forming a complex with other nuclear factors and epigenetic factors, in ...
Lilan Xue, Jingwen Zhang, Lihong Zhang, Fuqiang Fan, Xiaoyan Yin, Hengrui Tian, Bang Shen   +6 more
wiley   +1 more source

Knowledge among Drug Dispensers and Antimalarial Drug Prescribing Practices in Public Health Facilities in Dar es Salaam. [PDF]

, 2013
Irrational prescribing and dispensing of antimalarials has been identified as a contributing factor in the emergence of malaria parasites resistant to existing antimalarial drugs.
Kamuhabwa, Appolinary Ar, Silumbe, Richard   +1 more
core   +2 more sources

Effects of Cimetidine and Dolutegravir on the Endogenous Drug–Drug Interaction Biomarkers for Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Protein 1 in Healthy Volunteers

Clinical Pharmacology &Therapeutics, Volume 117, Issue 2, Page 523-533, February 2025.
This study was designed to assess the quantitative performance of endogenous drug–drug interaction (DDI) biomarkers (N1‐methylnicotinamide (1‐NMN), N1‐methyladenosine (m1A), and creatinine) for the organic cation transporters, OCT2 and MATE1/2K in the kidney.
Tomoki Koishikawa, Kaku Fujiwara, Kunal Taskar, Maciej J. Zamek‐Gliszczynski, Kenta Yoshida, Xiaoyan Chu, Hideki Hirabayashi, Jialin Mao, Kevin Rockich, Tadayuki Takashima, Yoshiyuki Yamaura, Yurong Lai, Yukana Tomoda, Tomoko Kito, Kazuya Maeda, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara   +17 more
wiley   +1 more source

New derivatives of the antimalarial drug Pyrimethamine in the control of melanoma tumor growth: an in vitro and in vivo study

Journal of experimental & clinical cancer research : CR, 2016
BackgroundThe antimalarial drug Pyrimethamine has been suggested to exert an antitumor activity by inducing apoptotic cell death in cancer cells, including metastatic melanoma cells.
Chiara Tommasino, L. Gambardella, Maria Buoncervello, R. Griffin, B. Golding, Manuela Alberton, D. Macchia, M. Spada, B. Cerbelli, G. d’Amati, W. Malorni, L. Gabriele, A. M. Giammarioli   +12 more
semanticscholar   +1 more source

Malaria vaccines and the new malaria agenda. [PDF]

, 2011
The development of an effective malaria vaccine has taken many decades, but there is now a good chance that the first malaria vaccine will be licensed within the next few years.
Greenwood, BM, Targett, GAT
core   +1 more source

The effect of STI screening during pregnancy on vertical transmission of HIV and adverse pregnancy outcomes in South Africa: a modelling study

Journal of the International AIDS Society, Volume 28, Issue 2, February 2025.
Abstract Introduction Sexually transmitted infections (STIs) in pregnancy are associated with an increased risk of vertical HIV transmission and adverse pregnancy and birth outcomes. In South Africa, syndromic management is the standard of care for STI management.
Dorothy C. Nyemba, Dvora L. Joseph‐Davey, Sinead Delany‐Moretlwe, Landon Myer, Leigh F. Johnson   +4 more
wiley   +1 more source

Effect of Propranolol Alone and in Combination with Pyrimethamine on Acute Murine Toxoplasmosis

Jundishapur Journal of Microbiology, 2015
Background: Toxoplasmosis is a public health problem worldwide. This complication principally affects immunodeficient patients and pregnant women.
M. Montazeri, A. Daryani, M. Ebrahimzadeh, E. Ahmadpour, M. Sharif, S. Sarvi   +5 more
semanticscholar   +1 more source

BONCAT-iTRAQ Labelling Reveals Molecular Markers of Adaptive Responses in Toxoplasma gondii to Pyrimethamine Treatment

Pathogens
We employed a BONCAT-iTRAQ labelling approach to investigate newly synthesised proteins (NSPs) in Toxoplasma gondii subjected to varying concentrations of the antifolate drug pyrimethamine.
John G. Mina, Anutthaman Parthasarathy, Exequiel O. Porta, Paul W. Denny, Karunakaran Kalesh   +4 more
doaj   +1 more source