Results 81 to 90 of about 43,381 (288)

The use of long acting sulfonamides, alone or with pyrimethamine, in malaria (with special reference to sulformetoxine)

Revista da Sociedade Brasileira de Medicina Tropical, 1967
Review of the early literature as well as more recent results show that sulfonamides possess a distinct antimalarial activity. However, when give alone, their action is less marked and slower than that of the antimalarials commonly used in the treatment ...
J. Herrero
doaj   +1 more source

Improved synchronous production of Plasmodium falciparum gametocytes in vitro.

, 2007
The sexual stages of the Plasmodium falciparum life cycle are attractive targets for vaccines and transmission blocking drugs. Difficulties in culturing and obtaining large amounts of sexual stage P.
Baker, David A, Fivelman, Quinton L, McRobert, Louisa, Saeed, Maha, Sharp, Sarah, Sutherland, Colin J, Swales, Claire A, Taylor, Cathy J   +7 more
core   +1 more source

Uptake of four or more doses of sulfadoxine pyrimethamine for intermittent preventive treatment of malaria during pregnancy in Zambia: findings from the 2018 malaria in pregnancy survey [PDF]

, 2023
Danny Sinyange, Mukumbuta Nawa, Lwito Mutale, Hudson Mumbole, Busiku Hamainza, Cephas Sialubanje   +5 more
openalex   +1 more source

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, Volume 21, Issue 1, January 2026.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

Examining catastrophic costs and benefit incidence of subsidized antiretroviral treatment (ART) programme in south-east Nigeria.

, 2008
OBJECTIVES: To examine the extent to which costs of subsidized antiretrovirals treatment (ART) programmes are catastrophic and the benefit incidence that accrues to different population groups.
Chukwuka, Chinwe, Dike, Nkem, Ichoku, Hyacinth, Onoka, Chima, Onwujekwe, Obinna, Onyedum, Cajetan, Uzochukwu, Benjamin   +6 more
core   +1 more source

Toxoplasmic encephalitis relapse rates with pyrimethamine-based therapy: systematic review and meta-analysis

Pathogens and Global Health, 2017
Toxoplasmic encephalitis (TE) is caused by Toxoplasma gondii infection and can be a life-threatening disease in immunocompromised patients. This study evaluated the rate of relapse associated with pyrimethamine-based maintenance therapy (i.e.
M. Connolly, E. Goodwin, C. Schey, J. Zummo   +3 more
semanticscholar   +1 more source

IL21—STAT3 controls the pentose phosphate pathway to support metabolic reprogramming and tumor progression in chronic lymphocytic leukemia

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Studying how microenvironmental cues influence metabolic reprogramming can uncover mechanisms driving tumor progression. Using an in vitro model with proliferative stimuli of the in vivo lymph node niche (LN)—including interleukin‐21 (IL‐21)—we examined metabolic rewiring in chronic lymphocytic leukemia (CLL) cells. We found that the metabolic
Rosita Del Prete, Vjola Tusha, Helga Simon‐Molas, Virginia Anna Gazziero, Federica Nardi, Roberta Drago, Gaia Bartolini, Danilo Licastro, Margherita Malchiodi, Cristina Mariottini, Giuseppe Marotta, Giulio Caravagna, Stefano Bruscoli, Eric Eldering, Alessandro Gozzetti, Monica Bocchia, Anna Kabanova   +16 more
wiley   +1 more source

Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in children with uncomplicated falciparum malaria on the coast of Benin, West Africa

Malaria Journal, 2007
Background Benin has recently shifted its national antimalarial drug policy from monotherapies to combinations containing artemisinin derivatives. When this decision was taken, the available information on alternatives to chloroquine and sulphadoxine ...
Coosemans Marc, Akogbeto Martin, Menten Joris, van Loen Harry, Van Overmeir Chantal, Agbowai Carine, Gazard Dorothée, Erhart Annette, Nahum Alain, Massougbodji Achille, D'Alessandro Umberto   +10 more
doaj   +1 more source

Saleability of Anti-malarials in Private Drug Shops in Muheza, Tanzania: A Baseline study in an era of assumed Artemisinin Ccombination Therapy (ACT). [PDF]

, 2011
Artemether-lumefantrine (ALu) replaced sulphadoxine-pymimethamine (SP) as the official first-line anti-malarial in Tanzania in November 2006. So far, artemisinin combination therapy (ACT) is contra-indicated during pregnancy by the national malaria ...
AM Rønn, B Wasunna, C Goodman, C Goodman, DS Tarimo, DS Tarimo, FM Ringsted, Frank M Ringsted, Ib C Bygbjerg, Isolide S Massawe, J Eriksen, M Alifrangis, M Alifrangis, Martha M Lemnge, Ministry of Health and Social Welfare URoT, MM Lemnge, MS Alilio, S Alba, S Alba, SE Nsimba, SE Nsimba, SE Nsimba, United Republic of Tanzania, VR Kamat, WE Harrington, World Health Organization, Z Premji   +26 more
core   +4 more sources

S3 Guideline for the treatment of psoriasis vulgaris, adapted from EuroGuiDerm – part 1: Treatment recommendations and monitoring

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 1, Page 122-137, January 2026.
Summary This first part of the updated German S3 guideline on the treatment of psoriasis vulgaris covers the sections on treatment recommendations, treatment goals, and monitoring of therapies. The recommendations are based on the current Cochrane network meta‐analysis, the results of which are also summarized.
Alexander Nast, Andreas Altenburg, Matthias Augustin, Frank Bachmann, Wolf‐Henning Boehncke, Markus Cornberg, Hilte Geerdes‐Fenge, Brit Häcker, Peter Härle, Joachim Klaus, Michaela Köhm, Arno Köllner, Ulrich Mrowietz, Hans‐Michael Ockenfels, Antonia Pennitz, Sandra Philipp, Thomas Richter, Thomas Rosenbach, Tom Schaberg, Martin Schlaeger, Gerhard Schmid‐Ott, Michael Sebastian, Karisa Thölken, Ralph von Kiedrowski, Uwe Willuhn, Christoph Zeyen   +25 more
wiley   +1 more source