Results 81 to 90 of about 41,516 (300)

Significant geographical differences in prevalence of mutations associated with Plasmodium falciparum and Plasmodium vivax drug resistance in two regions from Papua New Guinea [PDF]

, 2015
Drug resistance remains a major obstacle to malaria treatment and control. It can arise and spread rapidly, and vary substantially even at sub-national level.
Barnadas, Céline, Davis, Timothy M., Iga, Jonah, Javati, Sarah, Karunajeewa, Harin, Kiniboro, Benson, Koepfli, Cristian, Malau, Elisheba, Mueller, Ivo, Rare, Lawrence, Reeder, John C., Robinson, Leanne J., Senn, Nicolas, Siba, Peter M., Timinao, Lincoln, Zimmerman, Peter A.   +15 more
core   +3 more sources

Toxoplasma gondii C2 Domain Protein Deletion Mutant as a Promising Vaccine Against Toxoplasmosis in Mice

Microbial Biotechnology, Volume 18, Issue 5, May 2025.
Without TGME49_203240, a C2 domain‐containing protein, the virulence of T. gondii is much weakened. Immunisation of mice with the ME49Δ203240 strain produces a Th1‐biased immune response against reinfection by the T. gondii I, II and III strains. ABSTRACT Toxoplasma gondii (T.
Yifan Luo, Mingfeng He, Shengqiang Yang, Jiahui Qian, Zhengming He, Jiayin Xu, Liyu Guo, Siyu Xiao, Rui Fang   +8 more
wiley   +1 more source

Toxoplasmic encephalitis relapse rates with pyrimethamine-based therapy: systematic review and meta-analysis

Pathogens and Global Health, 2017
Toxoplasmic encephalitis (TE) is caused by Toxoplasma gondii infection and can be a life-threatening disease in immunocompromised patients. This study evaluated the rate of relapse associated with pyrimethamine-based maintenance therapy (i.e.
M. Connolly, E. Goodwin, C. Schey, J. Zummo   +3 more
semanticscholar   +1 more source

Genome comparison of progressively drug resistant Plasmodium falciparum lines derived from drug sensitive clone

Memorias do Instituto Oswaldo Cruz, 2001
Chloroquine has been the mainstay of malaria chemotherapy for the past five decades, but resistance is now widespread. Pyrimethamine or proguanil form an important component of some alternate drug combinations being used for treatment of uncomplicated ...
Ravi Toteja, Lathika Nair, VK Bhasin
doaj   +1 more source

Assessment of the Teratogenic Effect of Sulfadoxine-Pyrimethamine on the Chicken Embryo

Journal of Toxicology, 2022
Background. The sulfadoxine-pyrimethamine combination is a product used in the intermittent preventive treatment (IPT) of malaria in pregnant women in our country. To date, there is very little data on the teratogenic effect of this product.
Rachida Moussa Tari, Aboudoulatif Diallo, Emmanuelle Kouame, Phénix Assogba, Essotolom Badjabaissi, Lawson-Evi Povi, Batomayena Bakoma, Yao Potchoo, Kokou Tona   +8 more
doaj   +1 more source

A STUDY ON TOXICITY OF PYRIMETHAMINE FOR CHICKS

The Japanese Journal of Veterinary Science, 1968
Chicks were given 0, 3, 9, and 27 ppm of pyrimethamine contained in a diet for12 consecutive weeks and examined both clinically and histopathologically. The healingprocess of the pyrimethamine-induced Iesion was also observed.l. Clinically, chicks exhibited remarkable hyperchromic anemia and retardedgrowth after 27 ppm administration.
Seigo Isogai, Kohtaro Yasuda, Manabu Homma, Kaname Suzuki   +3 more
openaire   +4 more sources

STAT3 Signaling Pathway in Health and Disease

MedComm, Volume 6, Issue 4, April 2025.
An image depicting the role of STAT3 in various human diseases ABSTRACT Signal transducer and activator of transcription 3 (STAT3) is a critical transcription factor involved in multiple physiological and pathological processes. While STAT3 plays an essential role in homeostasis, its persistent activation has been implicated in the pathogenesis of ...
Md Abdus Samad, Iftikhar Ahmad, Aakifah Hasan, Mohammad Hassan Alhashmi, Arusha Ayub, Fahad A. Al‐Abbasi, Ajoy Kumer, Shams Tabrez   +7 more
wiley   +1 more source

Use of thin-layer chromatography to detect counterfeit sulfadoxine/pyrimethamine tablets with the wrong active ingredient in Malawi

Malaria Journal, 2016
Substandard and falsified anti-malarial medicines pose a serious threat to public health, especially in low-income countries. Appropriate technologies for drug quality analysis in resource-limited settings are important for the surveillance of the formal
Felix Khuluza, Stephen Kigera, R. Jähnke, L. Heide   +3 more
semanticscholar   +1 more source

Assessment of a national voucher scheme to deliver insecticide-treated mosquito nets to pregnant women.

, 2010
BACKGROUND: The benefits of a health-related intervention may be compromised by the challenges of delivering the intervention on a large scale. We analyzed the process involved in the Tanzania National Voucher Scheme, a system for delivering insecticide ...
Armstrong-Schellenberg, Joanna, Bruce, Jane, Hanson, Kara, Jones, Caroline, Marchant, Tanya, Mponda, Hadji, Nathan, Rose, Schellenberg, David, Sedekia, Yovitha   +8 more
core   +2 more sources

Do Health Workers' Preferences Influence their Practices? Assessment of Providers' Attitude and Personal use of new Treatment Recommendations for Management of Uncomplicated Malaria, Tanzania. [PDF]

, 2012
\ud \ud Due to growing antimalarial drug resistance, Tanzania changed malaria treatment policies twice within a decade. First in 2001 chloroquine (CQ) was replaced by sulfadoxine-pyrimethamine (SP) for management of uncomplicated malaria and by late 2006,
Khatib, Rashid A, Lutambi, Angelina M, Masanja, Irene M   +2 more
core   +3 more sources