Results 81 to 90 of about 42,597 (297)

Bilateral laryngeal paralysis (aplegia) occurring late during the recovery of a horse after orthopaedic surgery

Equine Veterinary Education, EarlyView.
Summary A 9‐year‐old male castrated Standardbred was presented for evaluation of a comminuted right front first phalanx fracture. On initial clinical examination, mild haemoconcentration and increased vital parameters were noted. After overnight hospitalisation, the horse underwent general anaesthesia for surgical fracture repair.
I. Lutvikadic, K. Hopster, B. Driessen
wiley   +1 more source

Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations

Annals of Neurology, 2017
Cu/Zn superoxide dismutase (SOD1) reduction prolongs survival in SOD1‐transgenic animal models. Pyrimethamine produces dose‐dependent SOD1 reduction in cell culture systems.
D. Lange, Mona Shahbazi, V. Silani, A. Ludolph, Jochen H Weishaupt, S. Ajroud-Driss, K. Fields, Rahul Remanan, S. Appel, C. Morelli, A. Doretti, L. Maderna, S. Messina, Ulrike Weiland, S. Marklund, P. Andersen   +15 more
semanticscholar   +1 more source

Equine protozoal myeloencephalitis—Presentation and progression

Equine Veterinary Education, EarlyView.
Summary Equine protozoal myeloencephalitis (EPM) remains one of the most frequently diagnosed neurological disorders of horses in North America, caused primarily by Sarcocystis neurona and less commonly Neospora hughesi. The clinical presentation is highly variable due to multifocal involvement of both grey and white matter, with asymmetric ataxia and ...
S. Austin, S. Gray
wiley   +1 more source

Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in children with uncomplicated falciparum malaria on the coast of Benin, West Africa

Malaria Journal, 2007
Background Benin has recently shifted its national antimalarial drug policy from monotherapies to combinations containing artemisinin derivatives. When this decision was taken, the available information on alternatives to chloroquine and sulphadoxine ...
Coosemans Marc, Akogbeto Martin, Menten Joris, van Loen Harry, Van Overmeir Chantal, Agbowai Carine, Gazard Dorothée, Erhart Annette, Nahum Alain, Massougbodji Achille, D'Alessandro Umberto   +10 more
doaj   +1 more source

Scaling-up co-trimoxazole prophylaxis in HIV-exposed and HIV-infected children in high HIV-prevalence countries. [PDF]

, 2007
Co-trimoxazole (trimethoprim-sulfamethoxazole) is a widely available antibiotic that substantially reduces HIV-related morbidity and mortality in both adults and children.
Abdel-Haq, Anglaret, Anglaret, Ansari, Anthony D Harries, Badri, Boerma, Chewe Luo, Chintu, Chintu, Creek, Gill, Graham, Graham, Gretchen Bachman, Grimwade, Manzi, Mermin, Mermin, Mwaungulu, Nathoo, Perez, Ponnet, Rony Zachariah, Ruffini, Stephen M Graham, Thera, Watera, Wiktor, Yazdanpanah, Zachariah, Zachariah, Zachariah, Zachariah   +33 more
core   +2 more sources

Toxoplasmic encephalitis relapse rates with pyrimethamine-based therapy: systematic review and meta-analysis

Pathogens and Global Health, 2017
Toxoplasmic encephalitis (TE) is caused by Toxoplasma gondii infection and can be a life-threatening disease in immunocompromised patients. This study evaluated the rate of relapse associated with pyrimethamine-based maintenance therapy (i.e.
M. Connolly, E. Goodwin, C. Schey, J. Zummo   +3 more
semanticscholar   +1 more source

Association of HLA‐B*53 With DRESS Syndrome in Patients Treated With Raltegravir: Two Case Reports and a Literature Review

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
ABSTRACT Introduction Raltegravir, an HIV integrase inhibitor, although generally well tolerated, may cause severe reactions such as drug reaction with eosinophilia and systemic symptoms (DRESS). This syndrome has been associated with impaired drug metabolism, viral reactivation and genetic factors including HLA‐B*53:01.
Cristina Ramos‐Del Moral, Pablo Rodríguez Cortés, Marcos Navares‐Gómez, Diana Campodónico, Susana Almenara de Riquer, Ana Barrios Blandino, Gina Mejía‐Abril, Antía Gómez‐Fernández, Olga Romero Sastre, Patricia Carles García, Francisco Abad‐Santos   +10 more
wiley   +1 more source

Genome comparison of progressively drug resistant Plasmodium falciparum lines derived from drug sensitive clone

Memorias do Instituto Oswaldo Cruz, 2001
Chloroquine has been the mainstay of malaria chemotherapy for the past five decades, but resistance is now widespread. Pyrimethamine or proguanil form an important component of some alternate drug combinations being used for treatment of uncomplicated ...
Ravi Toteja, Lathika Nair, VK Bhasin
doaj   +1 more source

Improved synchronous production of Plasmodium falciparum gametocytes in vitro.

, 2007
The sexual stages of the Plasmodium falciparum life cycle are attractive targets for vaccines and transmission blocking drugs. Difficulties in culturing and obtaining large amounts of sexual stage P.
Baker, David A, Fivelman, Quinton L, McRobert, Louisa, Saeed, Maha, Sharp, Sarah, Sutherland, Colin J, Swales, Claire A, Taylor, Cathy J   +7 more
core   +1 more source

Adherence to the combination of sulphadoxine-pyrimethamine and artesunate in the Maheba refugee settlement, Zambia. [PDF]

, 2004
Artemisinin-based combination therapy (ACT) is one strategy recommended to increase cure rates in malaria and to contain resistance to Plasmodium falciparum. In the Maheba refugee settlement, children aged 5 years or younger with a confirmed diagnosis of
Balkan, S, Depoortere, E, Fermon, F, Guthmann, J P, Legros, D, Nkandu, E, Sipilanyambe, N   +6 more
core   +2 more sources