Results 321 to 330 of about 290,598 (376)

Proton conductance by human uncoupling protein 1 is inhibited by purine and pyrimidine nucleotides. [PDF]

EMBO J
Jones SA, Sowton AP, Lacabanne D, King MS, Palmer SM, Zögg T, Pardon E, Steyaert J, Ruprecht JJ, Kunji ERS.   +9 more
europepmc   +1 more source

Cetuximab plus 5‐fluorouracil in patients with advanced cutaneous squamous cell carcinoma: a retrospective cohort study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background For patients with locally advanced (la) or metastatic (m) cutaneous squamous cell carcinoma (cSCC) who are not candidates for curative surgery/radiation or systemic anti‐PD1 therapy, anti‐EGFR in combination with chemotherapy is a rational treatment option.
Julia Huynh, Thomas Eigentler, Rose K. C. Moritz, Gabriela Poch, Max Schlaak, Gabor Dobos   +5 more
wiley   +1 more source

Uridine-sensitized screening identifies genes and metabolic regulators of nucleotide synthesis

Strefeler A, Baker ZN, Chollet S, Guerra RM, Ivanisevic J, Gallart-Ayala H, Pagliarini DJ, Jourdain AA.   +7 more
europepmc   +1 more source

Sustainable Synthesis of Polyfluoro-Pyrimido [1,2-<i>a</i>] Benzimidazole Derivatives Using a Tandem Strategy─Ultrasound and an Integrated Continuous Flow System. [PDF]

J Org Chem
Thavasianandam Seenivasan V, Chen NQ, Govindan K, Jayaram A, Lin YC, Li CH, Lin WY.   +6 more
europepmc   +1 more source

Purine but Not Pyrimidine De Novo Nucleotide Biosynthesis Inhibitors Strongly Enhance the Antiviral Effect of Corresponding Nucleobases Against Dengue Virus. [PDF]

Molecules
Bonnac LF, Dreis CD, Rai M, Geraghty RJ.
europepmc   +1 more source

An Efficient Synthesis of 3,5-Bis-Aminated Pyrazolo[1,5-a]Pyrimidines: Microwave-Assisted Copper Catalyzed C-3 Amination of 5-Amino-3-Bromo-Substituted Precursors. [PDF]

Molecules
Iorkula TH, Tolman BA, Ganiyu LO, Peterson MA.   +3 more
europepmc   +1 more source

Preparation and use of SER/GLU-based DES as a novel and potent catalyst for the green synthesis of pyrazolopyranopyrimidines. [PDF]

Sci Rep
Dehnokhalaji N, Habibi D, Monem A, Ranjbaran A.   +3 more
europepmc   +1 more source

Structural Insights into Broad-Range Polyphosphate Kinase 2-II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis. [PDF]

Chembiochem
Kuge M, Keppler M, Friedrich F, Saleem-Batcha R, Winter J, Prucker I, Germer P, Gerhardt S, Einsle O, Jung M, Jessen HJ, Andexer JN.   +11 more
europepmc   +1 more source

Correction to "Thieno[2,3-<i>d</i>]pyrimidine-2,4(1<i>H</i>,3<i>H</i>)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells". [PDF]

J Med Chem
Xiao Z, Osipyan A, Song S, Chen D, Schut RA, van Merkerk R, van der Wouden PE, Cool RH, Quax WJ, Melgert BN, Poelarends GJ, Dekker FJ.   +11 more
europepmc   +1 more source

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Pyrimidine: An elite heterocyclic leitmotif in drug discovery‐synthesis and biological activity

Chemical Biology and Drug Design, 2021
Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation
Sahaya Nadar, T. Khan
semanticscholar   +1 more source