Results 191 to 200 of about 15,307 (218)

Cleavage of pyrimidine dimers in specific DNA sequences by a pyrimidine dimer DNA-glycosylase of M. luteus

Nature, 1980
Pyrimidine dimer formation in response to UV radiation is governed by the thymine content of the potential dimer and the two flanking nucleotides. An enzymatic activity can be purified from Micrococcus luteus that cleaves the N-glycosyl bond between the 5' pyrimidine of a dimer and the corresponding sugar without rupture of a phosphodiester bond.
W A, Haseltine, L K, Gordon, C P, Lindan, R H, Grafstrom, N L, Shaper, L, Grossman   +5 more
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Mechanism of photosensitized dimerization of pyrimidines

Chemical Communications (London), 1968
Excited sensiter molecule in triplet state interacting with the target molecule (thymine) tranfers its triplet state energy to the latter. Two excited target molecule dimerize.
Kornhauser, Andrija, Herak, Janko, Trinajstić, Nenad   +2 more
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Photosensitized splitting of pyrimidine dimers by indole derivatives

Biochemical and Biophysical Research Communications, 1971
Abstract Excitation of tryptophan and 5-hydroxytryptophan at wavelengths longer than 290 and 310 nm, respectively, in the presence of pyrimidine dimers leads to a sensitized splitting of these dimers. The reaction is more efficient in frozen than in fluid aqueous solutions. The fluorescence of tryptophan and 5-hydroxytryptophan is quenched by thymine
C, Helene, M, Charlier
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Pyrimidine Dimers: Effect of Temperature on Photoinduction

Science, 1966
Ultraviolet-induced pyrimidine dimer formation in DNA and polyuridylic acid was inhibited on irradiation at 77°K. Enhancement of thymine dimer formation in solutions of DNA occurred upon addition of ethylene glycol. Low temperature measurements of absorbance of polyuridylic acid at low temperature showed that no significant alteration of the residues ...
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PYRIMIDINE DIMER FORMATION IN ULTRAVIOLET IRRADIATED TMV‐RNA

Photochemistry and Photobiology, 1967
Abstract— The formation of pyrimidine dimers on ultraviolet irradiation of TMV‐RNA in water is demonstrated in the region from 254 nm to 302 nm. No dimer is present in either unirradiated E. coli ribosomal RNA or TMV‐RNA. Dimer formation was also examined in TMV‐RNA irradiated in the presence of 5times10‐6 M proflavin, in high salt, on dry ice, and in ...
V, Merriam, M P, Gordon
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Cyclobutane-type pyrimidine dimers in polynucleotides.

Science (New York, N.Y.), 1966
The formation of cyclobutane-type dimers between adjacent pyrimidine residues in model polynucleotides or DNA may be represented by the general scheme See pdf 379.pdf Whereas the formation of all other known photoproducts follows the irreversible path See pdf 379.pdf Thus dimers are distinguished from other photoproducts by the fact that they can be ...
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Mass spectra of some dimeric photoproducts of pyrimidines

Tetrahedron, 1969
Abstract The mass spectra of photo-cycloaddition products of thymines and uracils and a photocoupled product of 5-bromouracil have been measured. Characteristic fragmentation has been documented for dimers joined through a cyclobutane ring, adducts derived from oxetane and azetidine linkages and a coupled product linked through a 5,5′-bond.
C, Fenselau, S Y, Wang
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Photomonomerization of pyrimidine dimers by indoles and proteins

Journal of Theoretical Biology, 1976
Abstract Model systems for the study of photoreactivation have been developed that utilize a variety of indole derivatives. These systems can split uracil cis-syn cyclobutadipyrimidine, either free or in RNA, when irradiated at wave-lengths absorbed only by the indole moiety. The ability of indole compounds to split dimers is closely related to their
J, Chen, C W, Huang, L, Hinman, M P, Gordon, D A, Deranleau   +4 more
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PHOTOREPAIR OF NONADJACENT PYRIMIDINE DIMERS BY DNA PHOTOLYASE

Photochemistry and Photobiology, 1995
Abstract— Photolyases reverse the harmful effects of UV light on cells by converting pyrimidine dimers (Pyr[]Pyr) into two pyrimidine monomers by utilizing near‐UV and visible light. Previous work has shown that photolyase repairs T[c,s]T and T[t,s]T in DNA as well as U[]U in RNA, all of which are formed by joining the two adjacent pyrimidines in a ...
S T, Kim, A, Sancar
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INCANDESCENT LAMPS CAN PRODUCE PYRIMIDINE DIMERS IN DNA

Photochemistry and Photobiology, 1985
Abstract—DNA molecules that have been exposed to light from a 150 W incandescent spot lamp are nicked by the Micrococcus luteus endonuclease specific for cyclobutyl‐type pyrimidine dimers. The production of these enzyme‐sensitive sites increases with increasing spot lamp exposure.
G, Ciarrocchi, B M, Sutherland, J C, Sutherland   +2 more
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