Results 61 to 70 of about 15,307 (218)

N-(2-Methoxybenzyl)-9-(oxolan-2-yl)-9H-purin-6-amine

Acta Crystallographica Section E, 2013
The title compound, C17H19N5O2, features an almost planar purine skeleton (r.m.s. deviation = 0.009 Å) substituted by a tetrahydrofuran ring, which adopts an envelope conformation. The purine and benzene rings subtend a dihedral angle of 66.70&
Zdeněk Trávníček, Igor Popa, Zdeněk Dvořák, Pavel Štarha   +3 more
doaj   +1 more source

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

Quinazoline-2,4(1H,3H)-dione

Acta Crystallographica Section E, 2008
In the title compound, C8H6N2O2, intermolecular N—H...O hydrogen bonds involving the amine and carbonyl groups create centrosymmetric dimers between adjacent nearly coplanar molecules.
Ge Liu
doaj   +1 more source

Germicidal potential and skin compatibility of an innovative UVC phototherapy device emitting at 234 nm

Photochemistry and Photobiology, EarlyView.
A phototherapy device emitting principally at 234 nm was assessed for antimicrobial efficacy against Methicillin‐resistant Staphylococcus aureus and evaluated for skin health hazards. Abstract Chronic wounds are a major healthcare issue affecting more than 10 million Americans each year, with a 5‐year survival similar to cancer and costing the ...
Zheng Tang, David Welch, Manuela Buonanno, Mark Gerber, David J. Brenner   +4 more
wiley   +1 more source

Methyl 4-[(pyrimidin-2-yl)carbamoyl]benzoate

Acta Crystallographica Section E, 2011
Molecules of the title compound, C13H11N3O3, are connected into centrosymmetric dimers via intermolecular N—H...N hydrogen bonds, generating an R22(8) motif.
Chun-Hsiang Lu, Chia-Jun Wu, Chun-Wei Yeh, Hui-Ling Hu, Jhy-Der Chen   +4 more
doaj   +1 more source

5-[(4-Ethoxyanilino)methyl]-N-(2-fluorophenyl)-6-methyl-2-phenylpyrimidin-4-amine

Acta Crystallographica Section E, 2012
The asymmetric unit of the title compound, C26H25FN4O, consists of two symmetry-independent molecules, denoted A and B. The conformation of each molecule is mainly determined by an intramolecular N—H...N hydrogen bond, which closes a six ...
Jerzy Cieplik, Marcin Stolarczyk, Iwona Bryndal, Tadeusz Lis   +3 more
doaj   +1 more source

Investigation of 222‐nm ultraviolet C irradiation bactericidal effect on the surgical field in a rabbit model

Photochemistry and Photobiology, EarlyView.
In a rabbit surgical field model seeded with polymicrobial flora, a single dose of 222‐nm UV‐C (500 mJ/cm2) markedly reduced bacterial colonies, achieving a bactericidal effect comparable to 254‐nm UV‐C (200 mJ/cm2), while no UV‐C irradiation showed heavy growth. Wound healing did not differ among groups. Microbiota profiling detected SSI‐relevant taxa
Tomoaki Fukui, Yuya Yamamoto, Kyohei Takase, Keisuke Oe, Kenichi Sawauchi, Ryota Nishida, Takahiro Niikura, Rena Kaigome, Masahiro Sasaki, Toru Koi, Hiroyuki Ohashi, Ryosuke Kuroda   +11 more
wiley   +1 more source

Ethyl 2-(4-carboxybenzylidene)-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate–N,N-dimethylformamide (1/1)

Acta Crystallographica Section E, 2012
In the title compound, C24H20N2O5S·C3H7NO, a benzene ring is positioned axially to the pyrimidine ring, which adopts a twist-boat conformation, and is inclined to its mean plane by 85.36 (7)°.
Noor Afshan Banu, V. Bheema Raju
doaj   +1 more source

Direct evidence of singlet molecular oxygen [O2 (1Δg)] production from UVA excited 6‐thioguanine

Photochemistry and Photobiology, EarlyView.
6‐Thioguanine (6‐TGua) is incorporated into DNA as a purine analogue, inhibiting cell replication. Patients treated with 6‐TGua are more prone to developing skin cancer due to the photoexcitation of 6‐TGua by UVA radiation (as illustrated in the Jablonski diagram). Upon exposure to UVA, the excited 6‐TGua generates 1O2.
André L. Lopes, Fernanda M. Prado, Helena C. Junqueira, Marisa H. G. Medeiros, Graziella E Ronsein, Jean Cadet, Paolo Di Mascio   +6 more
wiley   +1 more source

Synthesis and crystal structure of N-(4-chlorophenyl)-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-2-amine

Acta Crystallographica Section E: Crystallographic Communications, 2017
The title compound, C13H12ClN5, was synthesized by the cyclization of 1-(4,6-dimethylpyrimidin-2-yl)-4-phenylthiosemicarbazide in the presence of Ni(NO3)2. The molecular structure of the compound is essentially planar.
Hlib Repich, Svitlana Orysyk, Pavlo Savytskyi, Vasyl Pekhnyo   +3 more
doaj   +1 more source