Results 121 to 130 of about 11,329 (154)

Pyrimidine nucleoside transformations via anhydronucleoside

Pure and Applied Chemistry, 1969
Abstract
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Anticancer pyrimidines, pyrimidine nucleosides and prodrugs

1990
Of the plethora of pyrimidines, pyrimidine nucleosides, analogues and prodrug derivatives that have been synthesised and evaluated as anticancer agents, only two are in general clinical use. The long-studied 5-fluorouracil (5-FUra (1), see Scheme 9.1), and some nucleoside and prodrug derivatives, are used regularly for the treatment of breast cancer ...
M. MacCoss, M. J. Robins
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Pyrimidine nucleoside analogs in cancer treatment

Expert Review of Anticancer Therapy, 2003
Pyrimidine nucleoside analogs are essential components of hematological malignancy therapy and are also used in the treatment of solid tumors. These agents act as antimetabolites, compete with physiologic pyrimidine nucleosides and, consequently, interact with a large number of intracellular targets to induce cytotoxicity. Pyrimidine nucleoside analogs
Carlos M, Galmarini, Lars, Jordheim, Charles, Dumontet   +2 more
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Inhibition of Intestinal Pyrimidine Nucleoside Phosphorylases

Pharmaceutical Research, 1987
The activity of 5'-deoxy-5-fluorouridine (dFUR) depends on its activation to 5-fluorouracil (FU) by pyrimidine nucleoside phosphorylases. These enzymes are found in tumors and normal tissues, with the highest activity in the small intestines. The present study examined the inhibition of dFUR phosphorolysis in intestinal tissues.
M G, Wientjes, J L, Au
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Metabolism of pyrimidine bases and nucleosides by pyrimidine-nucleoside phosphorylases in cultured human lymphoid cells

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1987
The anabolism of pyrimidine ribo- and deoxyribonucleosides from uracil and thymine was investigated in phytohemagglutinin-stimulated human peripheral blood lymphocytes and in a Burkitt's lymphoma-derived cell line (Raji). We studied the ability of these cells to synthesize pyrimidine nucleosides by ribo- and deoxyribosyl transfer between pyrimidine ...
J L, Pérignon, D M, Bories, A M, Houllier, L, Thuillier, P H, Cartier   +4 more
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Nucleoside kinases in adult Schistosoma mansoni: Phosphorylation of pyrimidine nucleosides

Molecular and Biochemical Parasitology, 2014
Competition studies and column chromatography demonstrated that adults Schistosoma mansoni contains three nucleoside kinases that can phosphorylate pyrimidine nucleosides; a non-specific deoxyriboside kinase (EC 2.7.1.145), a specific uridine kinase and a specific cytidine kinase.
Fardos N M, Naguib, Mahmoud H, El Kouni
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Bis(pyrimidine nucleoside) Phosphates

Journal of Medicinal Chemistry, 1967
J A, Montgomery, H J, Thomas
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Analogs of pyrimidine nucleosides

Chemistry of Heterocyclic Compounds, 1974
R. A. Zhuk, L. A. Sherin', �. �. Liepin'sh, S. A. Giller   +3 more
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Pyrimidine Nucleosides

1959
J J, FOX, I, WEMPEN
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Analogs of pyrimidine nucleosides

Chemistry of Heterocyclic Compounds, 1970
R. A. Zhuk, Yu. A. Popelis, S. A. Hiller
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