Results 181 to 190 of about 72,841 (281)

Interventional human ocular safety experiments for 222‐nm far‐ultraviolet‐C lamp irradiation

Photochemistry and Photobiology, Volume 101, Issue 2, Page 517-526, March/April 2025.
To directly assess the ocular safety of 222‐nm far‐ultraviolet‐C (UVC) irradiation in humans, five subjects were exposed to 222‐nm UVC at doses of 22, 50, and 75 mJ/cm2. The findings indicate that far‐UVC irradiation does not cause “clinically significant photokeratitis” or long‐term ocular damage, though it may induce temporary discomfort.
Kazunobu Sugihara, Sachiko Kaidzu, Masahiro Sasaki, Masaki Tanito   +3 more
wiley   +1 more source

Disclosing New Insights on Pyrazolo[3,4-<i>d</i>] Pyrimidine Tethered Diverse Amino Acid Candidates as Potential DHFR Inhibitors and Anti-Virulence Agents. [PDF]

J Microbiol Biotechnol
Ibrahim TS, Salem IM, Alhakamy NA, Al-Mahmoudy AMM, Hegazy WAH.   +4 more
europepmc   +1 more source

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, EarlyView.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

DNA base pairs: the effect of the aromatic ring on the strength of the Watson-Crick hydrogen bonding.

Org Biomol Chem
Nieuwland C, van Well MJ, Guillaumes L, de Vey Mestdagh A, Dekker L, Nieuweboer C, Simon S, Fonseca Guerra C.   +7 more
europepmc   +1 more source

Access to Pyrazolo[1,5-<i>a</i>]pyrimidinone Regioisomers from Acylated Meldrum's Acids. [PDF]

Org Lett
Donzel M, Chorell E.
europepmc   +1 more source

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

Mechanistic Insights into the Stabilizing Role of Deep Eutectic Solvents for Nucleic Acids: An <i>In Silico</i> Analysis. [PDF]

J Phys Chem B
Hardy DE, Albert A, Lipani J, Metott ZJ, Mirjafari A, Wagle DV.   +5 more
europepmc   +1 more source

The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase

, 2009
Karine Malagu, Heather M. E. Duggan, Keith Menear, Marc Hummersone, Sylvie Gomez, C. L. Bailey, Peter Edwards, Jan Drzewiecki, Frédéric R. Leroux, Mar Jimenez Quesada, Gesine Hermann, Stephanie Maine, Carrie-Anne Molyneaux, Armelle Le Gall, James Pullen, Ian Hickson, Lisa M. Smith, Sharon Maguire, Niall M.B. Martin, Graeme Smith, Martin Pass   +20 more
openalex   +1 more source

Germicidal potential and skin compatibility of an innovative UVC phototherapy device emitting at 234 nm

Photochemistry and Photobiology, EarlyView.
A phototherapy device emitting principally at 234 nm was assessed for antimicrobial efficacy against Methicillin‐resistant Staphylococcus aureus and evaluated for skin health hazards. Abstract Chronic wounds are a major healthcare issue affecting more than 10 million Americans each year, with a 5‐year survival similar to cancer and costing the ...
Zheng Tang, David Welch, Manuela Buonanno, Mark Gerber, David J. Brenner   +4 more
wiley   +1 more source

[Expression of Concern] Combination of the FGFR4 inhibitor PD173074 and 5‑fluorouracil reduces proliferation and promotes apoptosis in gastric cancer. [PDF]

Oncol Rep
Ye YW, Hu S, Shi YQ, Zhang XF, Zhou Y, Zhao CL, Wang GJ, Wen JG, Zong H.   +8 more
europepmc   +1 more source