Results 221 to 230 of about 73,935 (281)

P2Y2 Purinergic Receptor Promotes Trafficking of Hematopoietic Stem/Progenitor Cells (HSPCs). [PDF]

Stem Cell Rev Rep
Adamiak M, Brzezniakiewicz-Janus K, Molenda M, Ratajczak J, Tang Y, Kucia M, Ratajczak MZ.   +6 more
europepmc   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Access to Pyrazolo[1,5-<i>a</i>]pyrimidinone Regioisomers from Acylated Meldrum's Acids. [PDF]

Org Lett
Donzel M, Chorell E.
europepmc   +1 more source

Impact of Underlying Liver Disease on the Risk and Prognostic Factors of Breast Cancer Liver Metastases: A Retrospective Multicenter Cohort Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Objective To examine factors influencing breast cancer liver metastases (BCLM) and assess the impact of underlying liver diseases (nonalcoholic fatty liver and HBsAg infection) on BCLM development. Methods Patients diagnosed with breast cancer at four affiliated hospitals in China between 2014 and 2024 were included.
Xiaowen Wang, Yuan Zhang, Qiwei Yang, Luo Yang, Yanhui Wang, Xiangxin Zeng, Long Zou, Yujuan Guo, Wenyang Zhou, Yuqi Jiang, Jiezhong Wu, Peng Zhang, Song Zhou, Guangjuan Zheng, Tao Huang, Genshu Wang, Kunpeng Hu   +16 more
wiley   +1 more source

Multicomponent catalyst-free regioselective synthesis and binding studies of 3-aroyl-2-methylimidazo[1,2-<i>a</i>]pyrimidines with BSA using biophysical and computational techniques. [PDF]

RSC Adv
Aggarwal R, Sharma M, Sumran G, Kumar P.
europepmc   +1 more source

Magnetic nanocatalyst for microwave-assisted synthesis of Benzo[4,5]imidazo[1,2-<i>a</i>]pyrimidines via A3 coupling. [PDF]

Front Chem
Pan Y.
europepmc   +1 more source

[Expression of Concern] Combination of the FGFR4 inhibitor PD173074 and 5‑fluorouracil reduces proliferation and promotes apoptosis in gastric cancer. [PDF]

Oncol Rep
Ye YW, Hu S, Shi YQ, Zhang XF, Zhou Y, Zhao CL, Wang GJ, Wen JG, Zong H.   +8 more
europepmc   +1 more source

The arginine/gallic acid-based deep eutectic solvent as a capable catalyst for the green synthesis of pyrano[2,3-d]pyrimidines. [PDF]

Sci Rep
Chegeni E, Habibi D, Monem A.
europepmc   +1 more source

Pyrimidine sufficiency is required for Sae two-component system signaling in <i>Staphylococcus aureus</i>. [PDF]

J Bacteriol
DiMaggio DA, Yeo W-S, Brinsmade SR.
europepmc   +1 more source

Heterocycle-Tethered Aurones: Synthesis and Evaluation of α-Glucosidase Inhibition. [PDF]

Biomed Res Int
Kobzar OL, Popova AV, Bondarenko SP, Mrug GP, Vovk AI, Frasinyuk MS.   +5 more
europepmc   +1 more source