Results 201 to 210 of about 88,038 (326)
PW01-001 – Pyrin-PSTPIP1 relation during cell migration [PDF]
, 2013 ZY Akkaya +4 more
openalex +1 more source
Protein tyrosine phosphatases as emerging targets for cancer immunotherapy
British Journal of Pharmacology, Volume 183, Issue 6, Page 1233-1249, March 2026.Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley +1 more source
[Latest Findings on NOD-Like Receptor Family Pyrin Domain Containing Protein 3 Inflammasome and Bone and Articular Diseases]. [PDF]
, 2023 Jiahe Wang +3 more
openalex +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1622-1637, March 2026.Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani +1 more
wiley +1 more source
, 2022 Pyrin inflammasome is a guard of RhoA activity. Pyrin activation is regulated by two steps: pyrin phosphorylation enacted by RhoA effectors PKN1/2, and a second checkpoint that relies on microtubule dynamics. Mutations in the pyrin encoding MEFV gene cause an auto-inflammatory disorder termed Familial Mediterranean fever (FMF).
openaire +1 more source
IGFBP4 is a Metric for Primary Biliary Cholangitis and Attenuates Biliary Epithelial Cell Injury
Liver International, Volume 46, Issue 3, March 2026.ABSTRACT Background and Aims Immune‐mediated bile duct injury is the primary histological feature of autoimmune cholestatic liver diseases. Macrophages, the most abundant immune cell population in the liver, have been postulated to play a critical role in biliary repair. However, it is unclear whether activated macrophages interact with injured biliary
Xing Zhou +12 more
wiley +1 more source
Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich–Containing Family, Pyrin Domain–Containing-3) Inflammasome in Cardiovascular Disorders [PDF]
, 2018 Zheng Wang +7 more
openalex +1 more source
Advanced Functional Materials, Volume 36, Issue 11, 5 February 2026.FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu +5 more
wiley +1 more source
Choroid plexus alterations in long COVID and their associations with Alzheimer's disease risks
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Choroid plexus (ChP) enlargement is a neuroimaging biomarker of neuroinflammation and neurodegeneration. However, evidence of ChP structural and perfusion alterations in long coronavirus disease (COVID) and their clinical relevance remains limited.
Huize Pang +11 more
wiley +1 more source