Results 211 to 220 of about 83,545 (299)

First‐In‐Human Safety, Pharmacokinetics, and Pharmacodynamics of VENT‐02 Freebase, a CNS‐Penetrant NLRP3 Inhibitor

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT The NLRP3 inflammasome is a central mediator of innate immunity and a key driver of inflammatory and neurodegenerative diseases. VENT‐02 is orally bioavailable, central nervous system‐penetrant, selective small‐molecule inhibitor of NLRP3. This first‐in‐human, randomized, double‐blind, placebo‐controlled study assessed the safety, tolerability,
Lisanne C. A. Smidt, Matthijs Moerland, Manon A. A. Jansen, Philip H. C. Kremer, Alexandra A. J. Sille, Pamela K. Strugala, Erica S. Klaassen, Anick Auger, Silvana Jananji, Rania Faidi, Kelly A. Pike, Loraine Warner, Andre Matta, Xavier Valencia, Ofer Spiegelstein   +14 more
wiley   +1 more source

TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950. [PDF]

Commun Biol
Lackner A, Picucci SI, Jiang W, Onyuru J, Campos M, Cabral JE, Leonidas L, Macapagal A, Lee H, Henriquez V, Wang K, Xu H, Qiu Y, Albrecht LV, Hoffman HM, McNulty R.   +15 more
europepmc   +1 more source

Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis

, 2020
Yong Hwan Park, Elaine F. Remmers, Wonyong Lee, Amanda K. Ombrello, Lawton K. Chung, Shilei Zhao, Deborah L. Stone, Maya I. Ivanov, Nicole A. Loeven, Karyl S. Barron, Patrycja Hoffmann, Michele Nehrebecky, Yeliz Z. Akkaya‐Ulum, Erdal Sağ, Banu Balcı‐Peynircioğlu, Ivona Aksentijevich, Ahmet Gül, Charles N. Rotimi, Hua Chen, James B. Bliska, Seza Özen, Daniel L. Kastner, Daniel Shriner, Jae Jin Chae   +23 more
openalex   +2 more sources

Pyrin proteininin hücre göçü üzerine etkisinin incelenmesi

, 2020
Familial Mediterranean Fever is an autosomal recesively inherited, autoinflammatory disease characterized by inflammatory episodes. The prevalance of disease is 1:1000 in Turkey. The drug of choice for the disease is colchicine which both relieves the patient from episodes and prevents late complications like amyloidosis.
openaire   +1 more source

Predictive Value of Pyroptosis Markers (NLRP3, HMGB1, and Caspase-1) in the Prognosis of Patients With Metastatic Breast Cancer: A Prospective Observational Study. [PDF]

Breast J
Zhang Y, He Y, Liu Q, Deng H.
europepmc   +1 more source

De novoCIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin-associated autoinflammatory diseases

, 2020
Donald Goldsmith, Hal M. Hoffman, John J. O’Shea, Sergio D. Rosenzweig, Ivona Aksentijevich, Janet Jones, Karyl S. Barron, Geryl Wood, Helene F. Rosenberg, Ricardo Russo, Robert Lipnick, James E. Balow, Hirsh D. Komarow, Peter B. Dent, Elaine F. Remmers, Sigrun R. Hofmann, Miroslawa Nowak, Frances Austin, Raphaela Goldbach‐Mansky, Mustapha Mallah, Nitza G. Shoham, Terry L. Moore, Nadira Mangra, Wendy T. Watford, Daniel J. Lovell, Kenneth N. Schikler, Barbara S. Adams, Hector Carrero, Daniel L. Kastner, Leonard I. Stein, Jae Jin Chae   +30 more
openalex   +1 more source

Oridonin‐Loaded PDA@Gel@GO Nanocapsules Modulate NLRP3 and Epithelial Repair in Colitis

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Mechanism of galactosylated carboxymethyl chitosan nanomicelle oral microcapsules delivering oridonin in alleviating colitis via targeting the NLRP3 inflammasome. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by sustained mucosal inflammation and epithelial barrier dysfunction, closely associated with aberrant NOD‐like
Wenbo Yuan, Qirui Zhao, Jing Hua, Lingyao Xu, Yufan Wang, Tongtong Xu, Zuchao Du, Liping Wu, Daxiang Cui   +8 more
wiley   +1 more source

Targeting NLRP3 inflammasome: a novel strategy for improving immune checkpoint inhibitor-associated pneumonitis. [PDF]

Transl Lung Cancer Res
Xiao SY, Ji YM, Liu Y, Lv YH, Dong Y, Liu MC, Lu YH, Cui PF, Li T, Cui XR, Hu Y.   +10 more
europepmc   +1 more source

Target Cell Activation of a Structurally Novel NOD-Like Receptor Pyrin Domain-Containing Protein 3 Inhibitor NT-0796 Enhances Potency [PDF]

Pamela J. Smolak, MyTrang Nguyen, Christine Diamond, Heather Wescott, John R. Doedens, Kenneth Schooley, John N. Snouwaert, Mark G. Bock, David Harrison, Alan P. Watt, Beverly H. Koller, Christopher A. Gabel   +11 more
openalex   +1 more source

The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways

, 2020
Jialu Zhou, Fan Zhang, Hong‐Ru Lin, Minxue Quan, Yaqin Yang, Yanni Lv, Zongnan He, Yisong Qian   +7 more
openalex   +1 more source