Results 211 to 220 of about 88,038 (326)

Pyrin mutations in complex hidradenitis suppurativa [PDF]

British Journal of Dermatology, 2019
S. Vural, M. Gündoğdu, E. Gökpınar İli, C.D. Durmaz, A. Vural, L. Steinmüller‐Magin, A. Kleinhempel, L.M. Holdt, T. Ruzicka, K.A. Giehl, H.I. Ruhi, A. Boyvat   +11 more
openaire   +1 more source

Rhein Inhibits NLRP3 Activation and Alleviates Microglial Pyroptosis After Intracerebral Hemorrhage in Rats

Brain and Behavior, Volume 16, Issue 2, February 2026.
Rhein treatment inhibits NLRP3 inflammasome activation, suppresses Caspase‐1/GSDMD‐mediated pyroptosis, reduces pro‐inflammatory cytokine release, promotes M2 polarization, and improves behavioral outcomes of ICH. These findings suggest that rhein protects against ICH‐induced brain injury through the inhibition of NLRP3‐dependent pyroptosis ...
Adalaiti Aimaiti, Qian Li, Tao Liu, Chen Chen, Xiaolin Xie, Jianshu Chu, Dilihumaer Nuermaimaiti, Yan Hu   +7 more
wiley   +1 more source

Über 4‐Ketoverbindungen der Pyrine [PDF]

Berichte der deutschen chemischen Gesellschaft, 1908
A. Michaelis, F. Engelhardt
openaire   +1 more source

BACH2 alleviates immune checkpoint inhibitors‐induced cardiac pyroptosis via transcriptionally promoting GRSF1

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Immune checkpoint inhibitors cause elevated cardiac injuries in humans and mice. ICIs cause myocyte pyroptosis and cardiotoxicity, not via the adaptive immune system BACH2 ameliorates ICIs‐induced pyroptosis through transcriptionally promoting GRSF1. Lipoic acid, as a transcriptional inducer of BACH2, suppresses ICIs‐induced cardiotoxicity.
Mengying Cao, Zilong Liu, Di Zhao, Hongyuan Zhang, Xinjie He, Wenhao Wang, Xiaolin Wang, Cheng Yang, Pan Gao, Yunzeng Zou   +9 more
wiley   +1 more source

Canakinumab as rescue therapy in familial Mediterranean fever refractory to conventional treatment

Drug Design, Development and Therapy, 2015
Mirella Alpa, Dario Roccatello Centro di Ricerche di Immunopatologia e Documentazione su Malattie Rare (CMID), Struttura Complessa Direzione Universitaria di Immunologia Clinica, Università di Torino e Ospedale G Bosco, Torino, ItalyAbstract ...
Alpa M, Roccatello D
doaj  

Microbial‐Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS‐resident cells such as microglia and astrocytes, contributing to ...
Matteo Ceccon, Francesca Ronchi
wiley   +1 more source

Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid, Muhammad Tauseef Sultan, Muhammad Maaz, Shehnshah Zafar, Anum Shoukat, Nudrat Khursheed, Matteo Bordiga, Amna Junaid   +7 more
wiley   +1 more source

Alpha‐Lipoic Acid Reduces NLRP3/ASC Expression and IL‐1β Release in Kupffer Cells and Improves Insulin Signaling in FL83B Hepatocytes Exposed to a Conditioned Medium

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Alpha‐lipoic acid (ALA) reduced NLRP3/ASC expression, attenuated upstream NF‐κB/ERK signaling, and decreased IL‐1β release while preserving mitochondrial membrane potential in murine Kupffer cells subjected to LPS priming and a second signal. Conditioned medium from ALA‐pretreated Kupffer cells (particularly 100 μM) enhanced glucose uptake and improved
Chih‐Yuan Ko, Yangming Martin Lo, Thi Kim Ngan Nguyen, Shao‐Ting Kao, Chung‐Hsin Wu, Wen‐Chung Huang, Szu‐Chuan Shen   +6 more
wiley   +1 more source

Familial Mediterranean Fever: A Comprehensive Review of Pathogenesis, Genetics, and Epigenetic Regulation. [PDF]

Balkan Med J
Ugurlu S, Kilinc OC, Karacan I, Parlar K.   +3 more
europepmc   +1 more source

Expression and correlation of the NOD-like receptor family, pyrin domain-containing 3 inflammasome and the silent information regulator 1 in patients with drug-resistant epilepsy

Qing Li, Zhenzhen Qu, Lijing Jia, Weiping Wang   +3 more
openalex   +1 more source