Results 301 to 310 of about 88,038 (326)

Doxorubicin induces cardiomyocyte pyroptosis via the TINCR-mediated posttranscriptional stabilization of NLR family pyrin domain containing 3.

Journal of Molecular and Cellular Cardiology, 2019
AIMS Doxorubicin (DOX), a widely used powerful chemotherapeutic component for cancer treatment, can give rise to severe cardiotoxicity that limits its clinical use.
L. Meng, Hui-Kuan Lin, Jie Zhang, N. Lin, Zhenzhu Sun, F. Gao, Hangqi Luo, T. Ni, Wenqiang Luo, J. Chi, Hangyuan Guo   +10 more
semanticscholar   +1 more source

Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3‐Driven Inflammation and Gouty Arthritis

Arthritis & Rheumatology, 2020
The NLRP3 inflammasome is closely linked to the pathophysiology of a wide range of inflammatory diseases. This study was undertaken to identify small molecules that directly bind to NLRP3 in order to develop pharmacologic interventions for NLRP3‐related ...
Gabsik Yang, H. Lee, Su-Jin Moon, K. M. Ko, J. Koh, J. Seok, J. Min, T. Heo, H. Kang, Yong-Yeon Cho, H. Lee, K. Fitzgerald, Joo Young Lee   +12 more
semanticscholar   +1 more source

Pyrin variants can burn out the plague

Nature Reviews Immunology, 2020
Mutations in pyrin that cause the autoinflammatory disease familial Mediterranean fever may have been selected for during plague pandemics.
openaire   +2 more sources

Corneal Toxicity of the Pediculocide A-200 Pyrinate

Archives of Ophthalmology, 1962
Five patients who had acute chemical erosion of the cornea secondary to the pediculocide A-200 Pyrinate * have been seen at the Massachusetts Eye and Ear Infirmary in the past 8 months. The symptoms were acute and severe, but complete healing ensued. All patients were between ages 3 and 8 years, and all had recently applied A-200 Pyrinate to the head ...
R D, REINECKE, R S, KINDER
openaire   +2 more sources

An alternative path for pyrin

Science Signaling, 2016
Mutations associated with an autoimmune disorder enable cells to assemble pyrin inflammasomes independently of microtubules.
openaire   +1 more source

Hereditary immunologic disorders caused by pyrin and cryopyrin

Current Allergy and Asthma Reports, 2007
A new family of hereditary immunologic disorders known as the autoinflammatory diseases involves dysregulation of the innate immune system. Elucidation of the genetic basis of these disorders has resulted in improved understanding of the disease pathophysiology of systemic and tissue inflammation, and has also revealed novel nonpathologic innate immune
openaire   +2 more sources

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence

Nature, 2021
Sangjoon Lee, , Yaqiu Wang
exaly  

Pyrin Inflammasome Activation Defines Colchicine-Responsive SURF Patients from FMF and Other Recurrent Fevers

Journal of Clinical Immunology
S. Palmeri, F. Penco, A. Bertoni, M. Bustaffa, C. Matucci-Cerinic, R. Papa, Enrico Drago, R. Caorsi, Anna Corcione, Paola Bocca, Cristina Scarone, Anna Rubartelli, Stefano Volpi, Marco Gattorno, I. Prigione   +14 more
semanticscholar   +1 more source

POS0234 P.E148Q POTENTIATES PYRIN INFLAMMASOME ACTIVATION

Annals of the Rheumatic Diseases, 2023
T. Reygaerts, P. Laohamonthonkul, K. Hrovat-Schaale, F. Moghaddas, P. Baker, P. Gray, S. Masters   +6 more
openaire   +1 more source

Recent Insights in Pyrin Inflammasome Activation: Identifying Potential Novel Therapeutic Approaches in Pyrin-Associated Autoinflammatory Syndromes

Pyrin is a cytosolic protein encoded by the MEFV gene, predominantly expressed in innate immune cells. Upon activation, it forms an inflammasome, a multimolecular complex that enables the activation and secretion of IL-1 beta and IL-18. In addition, the Pyrin inflammasome activates Gasdermin D leading to pyroptosis, a highly pro-inflammatory cell death.
WOUTERS, Flore, BOGIE, Jeroen, Wullaert, Andy, VAN DER HILST, Jeroen   +3 more
openaire   +1 more source