Results 281 to 290 of about 83,545 (299)

Hereditary immunologic disorders caused by pyrin and cryopyrin

Current Allergy and Asthma Reports, 2007
A new family of hereditary immunologic disorders known as the autoinflammatory diseases involves dysregulation of the innate immune system. Elucidation of the genetic basis of these disorders has resulted in improved understanding of the disease pathophysiology of systemic and tissue inflammation, and has also revealed novel nonpathologic innate immune
openaire   +2 more sources

Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

Cell Reports, 2022
Flora Magnotti, Jeremy Sousa, Wonyong Lee   +2 more
exaly  

POS0234 P.E148Q POTENTIATES PYRIN INFLAMMASOME ACTIVATION

Annals of the Rheumatic Diseases, 2023
T. Reygaerts, P. Laohamonthonkul, K. Hrovat-Schaale, F. Moghaddas, P. Baker, P. Gray, S. Masters   +6 more
openaire   +1 more source

The pyrin inflammasome and the Yersinia effector interaction

Immunological Reviews, 2020
Haleema S Malik, James B Bliska
exaly  

Recent Insights in Pyrin Inflammasome Activation: Identifying Potential Novel Therapeutic Approaches in Pyrin-Associated Autoinflammatory Syndromes

Pyrin is a cytosolic protein encoded by the MEFV gene, predominantly expressed in innate immune cells. Upon activation, it forms an inflammasome, a multimolecular complex that enables the activation and secretion of IL-1 beta and IL-18. In addition, the Pyrin inflammasome activates Gasdermin D leading to pyroptosis, a highly pro-inflammatory cell death.
WOUTERS, Flore, BOGIE, Jeroen, Wullaert, Andy, VAN DER HILST, Jeroen   +3 more
openaire   +1 more source

[The child with fever in pyrins time].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2007
Kone-Paut, I., Hentgen, V., Guillaume, Serge, Touitou, I.   +3 more
openaire   +2 more sources

Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation

Proceedings of the National Academy of Sciences of the United States of America, 2016
Wenqing Gao, Yupeng Wang, Feng Shao
exaly  

Cryopyrin and pyrin activate caspase-1, but not NF-κB, via ASC oligomerization

Cell Death and Differentiation, 2005
Je-Wook Yu
exaly  

Function and mechanism of the pyrin inflammasome

European Journal of Immunology, 2018
Rosalie Heilig, Petr Broz
exaly  

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Proceedings of the National Academy of Sciences of the United States of America, 2016
Pedro H V Saavedra, Nina Van Opdenbosch, Magdalena Matusiak   +2 more
exaly